Insulin-like Growth Factor-1/Insulin Bypasses Pref-1/FA1-mediated Inhibition of Adipocyte Differentiation

Pref-1 is a highly glycosylated Delta-like transmembrane protein containing six epidermal growth factor-like repeats in the extracellular domain. Pref-1 is abundantly expressed in preadipocytes, but expression is down-regulated during adipocyte differentiation. Forced expression of Pref-1 in 3T3-L1...

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Veröffentlicht in:	The Journal of biological chemistry 2003-06, Vol.278 (23), p.20906-20914
Hauptverfasser:	Zhang, Hongbin, Nøhr, Jane, Jensen, Charlotte H., Petersen, Rasmus K., Bachmann, Elin, Teisner, Børge, Larsen, Leif K., Mandrup, Susanne, Kristiansen, Karsten
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 3T3 Cells Adipocytes - cytology Adipocytes - metabolism Animals Calcium-Binding Proteins Cell Differentiation - physiology Dexamethasone - pharmacology Gene Expression Regulation Glucocorticoids - pharmacology Hypoglycemic Agents - pharmacology Insulin - pharmacology Insulin-Like Growth Factor I - pharmacology Intercellular Signaling Peptides and Proteins MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Phosphodiesterase Inhibitors - pharmacology Repressor Proteins - genetics Repressor Proteins - metabolism
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