Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer
Background: This study investigated the association of mucins and cluster of differentiation (CD) 56 with vascular and perineural invasion and survival in patients with periampullary cancer. Methods: Immunohistochemical staining was performed on formalin‐fixed pancreatic tissue microarrays (cancer,...
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| Veröffentlicht in: | British journal of surgery 2010-08, Vol.97 (8), p.1269-1278 |
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| creator | Aloysius, M. M. Zaitoun, A. M. Awad, S. Ilyas, M. Rowlands, B. J. Lobo, D. N. |
| description | Background:
This study investigated the association of mucins and cluster of differentiation (CD) 56 with vascular and perineural invasion and survival in patients with periampullary cancer.
Methods:
Immunohistochemical staining was performed on formalin‐fixed pancreatic tissue microarrays (cancer, chronic pancreatitis and normal pancreatic tissue) constructed from 126 pancreatic resections (cancer, 104; chronic pancreatitis, 22). Mucin (MUC) 1, MUC4 and MUC5AC expression was quantified using the immunohistochemical score (range 0–300), MUC3 expression was described as membranous or cytoplasmic, and expression of CD56, MUC2 and MUC6 as present or absent.
Results:
In cancers, vascular invasion correlated with overexpression (immunohistochemical score of 100 or more) of MUC1 (P = 0·003) and presence of MUC6 (P = 0·024), and perineural invasion correlated with overexpression of MUC5AC (P = 0·015). Reduced survival was observed with overexpression of MUC4 (P = 0·032) and MUC5AC (P = 0·048), membranous expression of MUC3 (P = 0·048), and presence of CD56 (P = 0·041). Perineural invasion also correlated with CD56 expression (P = 0·001). Overexpression of MUC4 and MUC5AC correlated with tumour recurrence (P = 0·001 and P = 0·034 respectively). Multivariable analysis identified membranous expression of MUC3 (P = 0·023), lymphatic invasion (P = 0·015) and perineural invasion (P = 0·004) as independent predictors of poor survival.
Conclusion:
Mucins and CD56 may be markers of prognosis in patients with periampullary cancer. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Promising predictors of prognosis |
| doi_str_mv | 10.1002/bjs.7107 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_733594136</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733594136</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3897-8f1f2e52467fec04246222e0bb681411549a8414746f9af1301c25505920eeb53</originalsourceid><addsrcrecordid>eNpFkUlPwzAQhS0EgrJI_ALkC-KUMt7i-AgFyg4Sq7hYTnCQIUuxG6D_HhcKPc1o5tPozXsIbRLoEwC6m7-GviQgF1CPsFQklKTZIuoBgEwIo2wFrYbwCkAYCLqMViikQLlSPXRz0RWuCdg0z3hwIFJsAq6Nf7M-4LbE465uO49d82GCa5sfbOTbl6YNLsQxHlnvTD3qqsr4CS5MU1i_jpZKUwW7Matr6O7o8HZwnJxfDU8Ge-dJwTIlk6wkJbWC8lSWtgAeG0qphTxPM8IJEVyZjBMueVoqU0btpKBCgFAUrM0FW0M7v3ejovfOhrGuXShslNLYtgtaMiYUj4ZEcmtGdnltn_XIu_jkRP_5EIHtGWBCYarSx0dcmHNUZSqTJHLJL_fpKjv53xPQ0xx0zEFPc9D7pzfTOuddGNuvfz4arFPJpNAPl0M9VPTo6f7xWp-xb2x_hqI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733594136</pqid></control><display><type>article</type><title>Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Aloysius, M. M. ; Zaitoun, A. M. ; Awad, S. ; Ilyas, M. ; Rowlands, B. J. ; Lobo, D. N.</creator><creatorcontrib>Aloysius, M. M. ; Zaitoun, A. M. ; Awad, S. ; Ilyas, M. ; Rowlands, B. J. ; Lobo, D. N.</creatorcontrib><description>Background:
This study investigated the association of mucins and cluster of differentiation (CD) 56 with vascular and perineural invasion and survival in patients with periampullary cancer.
Methods:
Immunohistochemical staining was performed on formalin‐fixed pancreatic tissue microarrays (cancer, chronic pancreatitis and normal pancreatic tissue) constructed from 126 pancreatic resections (cancer, 104; chronic pancreatitis, 22). Mucin (MUC) 1, MUC4 and MUC5AC expression was quantified using the immunohistochemical score (range 0–300), MUC3 expression was described as membranous or cytoplasmic, and expression of CD56, MUC2 and MUC6 as present or absent.
Results:
In cancers, vascular invasion correlated with overexpression (immunohistochemical score of 100 or more) of MUC1 (P = 0·003) and presence of MUC6 (P = 0·024), and perineural invasion correlated with overexpression of MUC5AC (P = 0·015). Reduced survival was observed with overexpression of MUC4 (P = 0·032) and MUC5AC (P = 0·048), membranous expression of MUC3 (P = 0·048), and presence of CD56 (P = 0·041). Perineural invasion also correlated with CD56 expression (P = 0·001). Overexpression of MUC4 and MUC5AC correlated with tumour recurrence (P = 0·001 and P = 0·034 respectively). Multivariable analysis identified membranous expression of MUC3 (P = 0·023), lymphatic invasion (P = 0·015) and perineural invasion (P = 0·004) as independent predictors of poor survival.
Conclusion:
Mucins and CD56 may be markers of prognosis in patients with periampullary cancer. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Promising predictors of prognosis</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.7107</identifier><identifier>PMID: 20602499</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Aged ; Ampulla of Vater - pathology ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; CD56 Antigen - metabolism ; Common Bile Duct Neoplasms - diagnosis ; Common Bile Duct Neoplasms - mortality ; Common Bile Duct Neoplasms - pathology ; Female ; General aspects ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Mucins - metabolism ; Neoplasm Invasiveness ; Pancreatitis, Chronic - diagnosis ; Prognosis</subject><ispartof>British journal of surgery, 2010-08, Vol.97 (8), p.1269-1278</ispartof><rights>Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3897-8f1f2e52467fec04246222e0bb681411549a8414746f9af1301c25505920eeb53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.7107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.7107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22989871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20602499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aloysius, M. M.</creatorcontrib><creatorcontrib>Zaitoun, A. M.</creatorcontrib><creatorcontrib>Awad, S.</creatorcontrib><creatorcontrib>Ilyas, M.</creatorcontrib><creatorcontrib>Rowlands, B. J.</creatorcontrib><creatorcontrib>Lobo, D. N.</creatorcontrib><title>Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
This study investigated the association of mucins and cluster of differentiation (CD) 56 with vascular and perineural invasion and survival in patients with periampullary cancer.
Methods:
Immunohistochemical staining was performed on formalin‐fixed pancreatic tissue microarrays (cancer, chronic pancreatitis and normal pancreatic tissue) constructed from 126 pancreatic resections (cancer, 104; chronic pancreatitis, 22). Mucin (MUC) 1, MUC4 and MUC5AC expression was quantified using the immunohistochemical score (range 0–300), MUC3 expression was described as membranous or cytoplasmic, and expression of CD56, MUC2 and MUC6 as present or absent.
Results:
In cancers, vascular invasion correlated with overexpression (immunohistochemical score of 100 or more) of MUC1 (P = 0·003) and presence of MUC6 (P = 0·024), and perineural invasion correlated with overexpression of MUC5AC (P = 0·015). Reduced survival was observed with overexpression of MUC4 (P = 0·032) and MUC5AC (P = 0·048), membranous expression of MUC3 (P = 0·048), and presence of CD56 (P = 0·041). Perineural invasion also correlated with CD56 expression (P = 0·001). Overexpression of MUC4 and MUC5AC correlated with tumour recurrence (P = 0·001 and P = 0·034 respectively). Multivariable analysis identified membranous expression of MUC3 (P = 0·023), lymphatic invasion (P = 0·015) and perineural invasion (P = 0·004) as independent predictors of poor survival.
Conclusion:
Mucins and CD56 may be markers of prognosis in patients with periampullary cancer. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Promising predictors of prognosis</description><subject>Aged</subject><subject>Ampulla of Vater - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>CD56 Antigen - metabolism</subject><subject>Common Bile Duct Neoplasms - diagnosis</subject><subject>Common Bile Duct Neoplasms - mortality</subject><subject>Common Bile Duct Neoplasms - pathology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucins - metabolism</subject><subject>Neoplasm Invasiveness</subject><subject>Pancreatitis, Chronic - diagnosis</subject><subject>Prognosis</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUlPwzAQhS0EgrJI_ALkC-KUMt7i-AgFyg4Sq7hYTnCQIUuxG6D_HhcKPc1o5tPozXsIbRLoEwC6m7-GviQgF1CPsFQklKTZIuoBgEwIo2wFrYbwCkAYCLqMViikQLlSPXRz0RWuCdg0z3hwIFJsAq6Nf7M-4LbE465uO49d82GCa5sfbOTbl6YNLsQxHlnvTD3qqsr4CS5MU1i_jpZKUwW7Matr6O7o8HZwnJxfDU8Ge-dJwTIlk6wkJbWC8lSWtgAeG0qphTxPM8IJEVyZjBMueVoqU0btpKBCgFAUrM0FW0M7v3ejovfOhrGuXShslNLYtgtaMiYUj4ZEcmtGdnltn_XIu_jkRP_5EIHtGWBCYarSx0dcmHNUZSqTJHLJL_fpKjv53xPQ0xx0zEFPc9D7pzfTOuddGNuvfz4arFPJpNAPl0M9VPTo6f7xWp-xb2x_hqI</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Aloysius, M. M.</creator><creator>Zaitoun, A. M.</creator><creator>Awad, S.</creator><creator>Ilyas, M.</creator><creator>Rowlands, B. J.</creator><creator>Lobo, D. N.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer</title><author>Aloysius, M. M. ; Zaitoun, A. M. ; Awad, S. ; Ilyas, M. ; Rowlands, B. J. ; Lobo, D. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3897-8f1f2e52467fec04246222e0bb681411549a8414746f9af1301c25505920eeb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Ampulla of Vater - pathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>CD56 Antigen - metabolism</topic><topic>Common Bile Duct Neoplasms - diagnosis</topic><topic>Common Bile Duct Neoplasms - mortality</topic><topic>Common Bile Duct Neoplasms - pathology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mucins - metabolism</topic><topic>Neoplasm Invasiveness</topic><topic>Pancreatitis, Chronic - diagnosis</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aloysius, M. M.</creatorcontrib><creatorcontrib>Zaitoun, A. M.</creatorcontrib><creatorcontrib>Awad, S.</creatorcontrib><creatorcontrib>Ilyas, M.</creatorcontrib><creatorcontrib>Rowlands, B. J.</creatorcontrib><creatorcontrib>Lobo, D. N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aloysius, M. M.</au><au>Zaitoun, A. M.</au><au>Awad, S.</au><au>Ilyas, M.</au><au>Rowlands, B. J.</au><au>Lobo, D. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2010-08</date><risdate>2010</risdate><volume>97</volume><issue>8</issue><spage>1269</spage><epage>1278</epage><pages>1269-1278</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background:
This study investigated the association of mucins and cluster of differentiation (CD) 56 with vascular and perineural invasion and survival in patients with periampullary cancer.
Methods:
Immunohistochemical staining was performed on formalin‐fixed pancreatic tissue microarrays (cancer, chronic pancreatitis and normal pancreatic tissue) constructed from 126 pancreatic resections (cancer, 104; chronic pancreatitis, 22). Mucin (MUC) 1, MUC4 and MUC5AC expression was quantified using the immunohistochemical score (range 0–300), MUC3 expression was described as membranous or cytoplasmic, and expression of CD56, MUC2 and MUC6 as present or absent.
Results:
In cancers, vascular invasion correlated with overexpression (immunohistochemical score of 100 or more) of MUC1 (P = 0·003) and presence of MUC6 (P = 0·024), and perineural invasion correlated with overexpression of MUC5AC (P = 0·015). Reduced survival was observed with overexpression of MUC4 (P = 0·032) and MUC5AC (P = 0·048), membranous expression of MUC3 (P = 0·048), and presence of CD56 (P = 0·041). Perineural invasion also correlated with CD56 expression (P = 0·001). Overexpression of MUC4 and MUC5AC correlated with tumour recurrence (P = 0·001 and P = 0·034 respectively). Multivariable analysis identified membranous expression of MUC3 (P = 0·023), lymphatic invasion (P = 0·015) and perineural invasion (P = 0·004) as independent predictors of poor survival.
Conclusion:
Mucins and CD56 may be markers of prognosis in patients with periampullary cancer. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Promising predictors of prognosis</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20602499</pmid><doi>10.1002/bjs.7107</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of surgery, 2010-08, Vol.97 (8), p.1269-1278 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Ampulla of Vater - pathology Biological and medical sciences Biomarkers, Tumor - metabolism CD56 Antigen - metabolism Common Bile Duct Neoplasms - diagnosis Common Bile Duct Neoplasms - mortality Common Bile Duct Neoplasms - pathology Female General aspects Humans Immunohistochemistry Kaplan-Meier Estimate Male Medical sciences Middle Aged Mucins - metabolism Neoplasm Invasiveness Pancreatitis, Chronic - diagnosis Prognosis |
| title | Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer |
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