An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

Recent years have seen intensive progress in measuring protein translation. However, the contributions of coding sequences to the efficiency of the process remain unclear. Here, we identify a universally conserved profile of translation efficiency along mRNAs computed based on adaptation between cod...

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Veröffentlicht in:	Cell 2010-04, Vol.141 (2), p.344-354
Hauptverfasser:	Tuller, Tamir, Carmi, Asaf, Vestsigian, Kalin, Navon, Sivan, Dorfan, Yuval, Zaborske, John, Pan, Tao, Dahan, Orna, Furman, Itay, Pilpel, Yitzhak
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Evolution Codon - metabolism Protein Biosynthesis PROTEINS Ribosomes - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Selection, Genetic
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