A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides
The aim of this study was to characterize new nanoparticles (NPs) containing chitosan (CS), or CS/cyclodextrin (CDs), and evaluate their potential for the oral delivery of the peptide glutathione (GSH). More precisely, NP formulations composed of CS, CS/α-CD and CS/sulphobutyl ether-β-cyclodextrin (...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2010-05, Vol.75 (1), p.26-32 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
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| creator | Trapani, Adriana Lopedota, Angela Franco, Massimo Cioffi, Nicola Ieva, Eliana Garcia-Fuentes, Marcos Alonso, Maria José |
| description | The aim of this study was to characterize new nanoparticles (NPs) containing chitosan (CS), or CS/cyclodextrin (CDs), and evaluate their potential for the oral delivery of the peptide glutathione (GSH). More precisely, NP formulations composed of CS, CS/α-CD and CS/sulphobutyl ether-β-cyclodextrin (SBE
7m-β-CD) were investigated for this application. CS/CD NPs showed particle sizes ranging from 200 to 500
nm. GSH was loaded more efficiently in CS/SBE
7m-β-CD NPs by forming a complex between the tripeptide and the CD. X-ray Photoelectron Spectroscopy (XPS) analysis suggested that GSH is located in the core of CS/SBE
7m-β-CD NPs and that it is almost absent from the NP surface. Release studies performed
in vitro at pH 1.2 and pH 6.8 showed that NP release properties can be modulated by selecting an appropriate CD. Transport studies performed in the frog intestine model confirmed that both CS and CS/CD nanoparticles could induce permeabilization of the intestinal epithelia. However, CS/SBE
7m-β-CD NPs provided absorption-enhancing properties in all segments of the duodenum, whereas CS NPs effect was restricted to the first segment of the duodenum. From the data obtained, we believe that CS/CD nanoparticles might represent an interesting technological platform for the oral administration of small peptides. |
| doi_str_mv | 10.1016/j.ejpb.2010.01.010 |
| format | Article |
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7m-β-CD) were investigated for this application. CS/CD NPs showed particle sizes ranging from 200 to 500
nm. GSH was loaded more efficiently in CS/SBE
7m-β-CD NPs by forming a complex between the tripeptide and the CD. X-ray Photoelectron Spectroscopy (XPS) analysis suggested that GSH is located in the core of CS/SBE
7m-β-CD NPs and that it is almost absent from the NP surface. Release studies performed
in vitro at pH 1.2 and pH 6.8 showed that NP release properties can be modulated by selecting an appropriate CD. Transport studies performed in the frog intestine model confirmed that both CS and CS/CD nanoparticles could induce permeabilization of the intestinal epithelia. However, CS/SBE
7m-β-CD NPs provided absorption-enhancing properties in all segments of the duodenum, whereas CS NPs effect was restricted to the first segment of the duodenum. From the data obtained, we believe that CS/CD nanoparticles might represent an interesting technological platform for the oral administration of small peptides.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2010.01.010</identifier><identifier>PMID: 20102738</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Chitosan ; Cyclodextrins ; Cyclodextrins - administration & dosage ; Cyclodextrins - pharmacokinetics ; Drug Carriers - administration & dosage ; Drug Carriers - pharmacokinetics ; Drug Delivery Systems - methods ; General pharmacology ; Glutathione ; Glutathione - administration & dosage ; Glutathione - pharmacokinetics ; Intestinal Absorption - drug effects ; Intestinal Absorption - physiology ; Medical sciences ; Nanoparticles ; Nanoparticles - administration & dosage ; Oral administration ; Peptide Fragments - administration & dosage ; Peptide Fragments - pharmacokinetics ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Rana esculenta</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2010-05, Vol.75 (1), p.26-32</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-46596c9bece6255f08f03ce7f02f08381079902148f4e2927776f95a4248af5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejpb.2010.01.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22688670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20102738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trapani, Adriana</creatorcontrib><creatorcontrib>Lopedota, Angela</creatorcontrib><creatorcontrib>Franco, Massimo</creatorcontrib><creatorcontrib>Cioffi, Nicola</creatorcontrib><creatorcontrib>Ieva, Eliana</creatorcontrib><creatorcontrib>Garcia-Fuentes, Marcos</creatorcontrib><creatorcontrib>Alonso, Maria José</creatorcontrib><title>A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>The aim of this study was to characterize new nanoparticles (NPs) containing chitosan (CS), or CS/cyclodextrin (CDs), and evaluate their potential for the oral delivery of the peptide glutathione (GSH). More precisely, NP formulations composed of CS, CS/α-CD and CS/sulphobutyl ether-β-cyclodextrin (SBE
7m-β-CD) were investigated for this application. CS/CD NPs showed particle sizes ranging from 200 to 500
nm. GSH was loaded more efficiently in CS/SBE
7m-β-CD NPs by forming a complex between the tripeptide and the CD. X-ray Photoelectron Spectroscopy (XPS) analysis suggested that GSH is located in the core of CS/SBE
7m-β-CD NPs and that it is almost absent from the NP surface. Release studies performed
in vitro at pH 1.2 and pH 6.8 showed that NP release properties can be modulated by selecting an appropriate CD. Transport studies performed in the frog intestine model confirmed that both CS and CS/CD nanoparticles could induce permeabilization of the intestinal epithelia. However, CS/SBE
7m-β-CD NPs provided absorption-enhancing properties in all segments of the duodenum, whereas CS NPs effect was restricted to the first segment of the duodenum. From the data obtained, we believe that CS/CD nanoparticles might represent an interesting technological platform for the oral administration of small peptides.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chitosan</subject><subject>Cyclodextrins</subject><subject>Cyclodextrins - administration & dosage</subject><subject>Cyclodextrins - pharmacokinetics</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - pharmacokinetics</subject><subject>Drug Delivery Systems - methods</subject><subject>General pharmacology</subject><subject>Glutathione</subject><subject>Glutathione - administration & dosage</subject><subject>Glutathione - pharmacokinetics</subject><subject>Intestinal Absorption - drug effects</subject><subject>Intestinal Absorption - physiology</subject><subject>Medical sciences</subject><subject>Nanoparticles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Oral administration</subject><subject>Peptide Fragments - administration & dosage</subject><subject>Peptide Fragments - pharmacokinetics</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Rana esculenta</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9rFDEYh4Modq1-AQ-Si3iabf5OZsBLKWqFghc9h2zmDc2SScYkW9wP4Pc24671VggkeXl-v4QHobeUbCmh_dV-C_tlt2WkDQhtizxDGzoo3nEh6HO0ISMfu15QeoFelbInhAglh5foYo0wxYcN-n2NbZoXk031D4BLPUxHnBy2976mYiI2cXq8XNmjDWmCXzX7iKOJqQWrtwEKNgUvqUKs3gRsTc4ecsEuZVzvAafcphOE9kb-219mEwJeYKl-gvIavXAmFHhz3i_Rj8-fvt_cdnffvny9ub7rrJC0dqKXY2_HHVjomZSODI5wC8oR1s58oESNI2FUDE4AG5lSqnejNIKJwTgJ_BJ9OPUuOf08QKl69sVCCCZCOhStOJcj40w2kp1Im1MpGZxesp9NPmpK9Gpf7_VqX68qNaFtkRZ6d64_7GaYHiP_dDfg_RkwxZrgsonWl_8c64ehV2vRxxMHTcZDM6mL9RAtTD6DrXpK_ql__AFE86Ss</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Trapani, Adriana</creator><creator>Lopedota, Angela</creator><creator>Franco, Massimo</creator><creator>Cioffi, Nicola</creator><creator>Ieva, Eliana</creator><creator>Garcia-Fuentes, Marcos</creator><creator>Alonso, Maria José</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides</title><author>Trapani, Adriana ; Lopedota, Angela ; Franco, Massimo ; Cioffi, Nicola ; Ieva, Eliana ; Garcia-Fuentes, Marcos ; Alonso, Maria José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-46596c9bece6255f08f03ce7f02f08381079902148f4e2927776f95a4248af5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chitosan</topic><topic>Cyclodextrins</topic><topic>Cyclodextrins - administration & dosage</topic><topic>Cyclodextrins - pharmacokinetics</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - pharmacokinetics</topic><topic>Drug Delivery Systems - methods</topic><topic>General pharmacology</topic><topic>Glutathione</topic><topic>Glutathione - administration & dosage</topic><topic>Glutathione - pharmacokinetics</topic><topic>Intestinal Absorption - drug effects</topic><topic>Intestinal Absorption - physiology</topic><topic>Medical sciences</topic><topic>Nanoparticles</topic><topic>Nanoparticles - administration & dosage</topic><topic>Oral administration</topic><topic>Peptide Fragments - administration & dosage</topic><topic>Peptide Fragments - pharmacokinetics</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Rana esculenta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trapani, Adriana</creatorcontrib><creatorcontrib>Lopedota, Angela</creatorcontrib><creatorcontrib>Franco, Massimo</creatorcontrib><creatorcontrib>Cioffi, Nicola</creatorcontrib><creatorcontrib>Ieva, Eliana</creatorcontrib><creatorcontrib>Garcia-Fuentes, Marcos</creatorcontrib><creatorcontrib>Alonso, Maria José</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trapani, Adriana</au><au>Lopedota, Angela</au><au>Franco, Massimo</au><au>Cioffi, Nicola</au><au>Ieva, Eliana</au><au>Garcia-Fuentes, Marcos</au><au>Alonso, Maria José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>75</volume><issue>1</issue><spage>26</spage><epage>32</epage><pages>26-32</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>The aim of this study was to characterize new nanoparticles (NPs) containing chitosan (CS), or CS/cyclodextrin (CDs), and evaluate their potential for the oral delivery of the peptide glutathione (GSH). More precisely, NP formulations composed of CS, CS/α-CD and CS/sulphobutyl ether-β-cyclodextrin (SBE
7m-β-CD) were investigated for this application. CS/CD NPs showed particle sizes ranging from 200 to 500
nm. GSH was loaded more efficiently in CS/SBE
7m-β-CD NPs by forming a complex between the tripeptide and the CD. X-ray Photoelectron Spectroscopy (XPS) analysis suggested that GSH is located in the core of CS/SBE
7m-β-CD NPs and that it is almost absent from the NP surface. Release studies performed
in vitro at pH 1.2 and pH 6.8 showed that NP release properties can be modulated by selecting an appropriate CD. Transport studies performed in the frog intestine model confirmed that both CS and CS/CD nanoparticles could induce permeabilization of the intestinal epithelia. However, CS/SBE
7m-β-CD NPs provided absorption-enhancing properties in all segments of the duodenum, whereas CS NPs effect was restricted to the first segment of the duodenum. From the data obtained, we believe that CS/CD nanoparticles might represent an interesting technological platform for the oral administration of small peptides.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20102738</pmid><doi>10.1016/j.ejpb.2010.01.010</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of pharmaceutics and biopharmaceutics, 2010-05, Vol.75 (1), p.26-32 |
| issn | 0939-6411 1873-3441 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Animals Biological and medical sciences Chitosan Cyclodextrins Cyclodextrins - administration & dosage Cyclodextrins - pharmacokinetics Drug Carriers - administration & dosage Drug Carriers - pharmacokinetics Drug Delivery Systems - methods General pharmacology Glutathione Glutathione - administration & dosage Glutathione - pharmacokinetics Intestinal Absorption - drug effects Intestinal Absorption - physiology Medical sciences Nanoparticles Nanoparticles - administration & dosage Oral administration Peptide Fragments - administration & dosage Peptide Fragments - pharmacokinetics Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rana esculenta |
| title | A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides |
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