Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy

The aim of this study was to obtain and to characterize microemulsions containing 5-aminolevulinic acid (5-ALA) and to investigate the influence of these systems in drug skin permeation for further topical photodynamic therapy (PDT). 5-ALA was incorporated in water-in-oil (W/O), bicontinuous (Bc), a...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2010-05, Vol.75 (1), p.48-55
Hauptverfasser:	de Campos Araújo, Luciana Mattoso Pires, Thomazine, José Antônio, Lopez, Renata Fonseca Vianna
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminolevulinic acid Administration, Topical Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - pharmacokinetics Animals Biological and medical sciences Drug Delivery Systems - methods Drug Delivery Systems - trends Drug Discovery - methods Drug Discovery - trends Emulsions General pharmacology In Vitro Techniques Medical sciences Mice Mice, Hairless Microemulsion Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Photochemotherapy - methods Photochemotherapy - trends Photodynamic therapy Protoporphyrin Skin Absorption - drug effects Skin Absorption - physiology Skin penetration Swine
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