In vitro anticancer studies of α- and β- d-glucopyranose betulin anomers

Four derivatives of betulin containing a d-glucopyranosyl moiety at C3 position were synthesized and characterized by 1H and 13C NMR spectroscopy as well as mass spectrometry. The crystal structure of 28-O-acetylbetulin-3-yl-β- d-(2′,3′,4′,6′-tetra-O-acetyl)glucopyranoside was determined. The compou...

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Veröffentlicht in:	Chemico-biological interactions 2010-04, Vol.185 (2), p.128-136
Hauptverfasser:	Kommera, Harish, Kaluđerović, Goran N., Bette, Martin, Kalbitz, Jutta, Fuchs, Petra, Fulda, Simone, Mier, Walter, Paschke, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - physiology Betulin Betulinic acid Caspase Caspase 3 - metabolism Cell Cycle - drug effects Cell Cycle - physiology Cell Line, Tumor Cytotoxicity DNA Fragmentation - drug effects Drug Screening Assays, Antitumor Glucose - analogs & derivatives Glucose - chemical synthesis Glucose - chemistry Glucose - pharmacology HCT116 Cells Humans Isomerism Magnetic Resonance Spectroscopy Mass Spectrometry Time Factors Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - pharmacology X-Ray Diffraction
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