Altered apolipoprotein E glycosylation is associated with Abeta(42) accumulation in an animal model of Niemann-Pick Type C disease

Neurodegeneration is the final cause of death in Niemann-Pick Type C (NPC) disease, a cholesterol-storage disorder. Accumulating evidence indicates that NPC may share common pathological mechanisms with Alzheimer's disease, including the link between aberrant cholesterol metabolism and amyloid-...

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Veröffentlicht in:	Journal of neurochemistry 2010-03, Vol.112 (6), p.1619-1626
Hauptverfasser:	Chua, Ching-Ching, Lim, Mei-Li, Wong, Boon-Seng
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Brain - pathology Disease Models, Animal Enzyme-Linked Immunosorbent Assay - methods Gene Expression Regulation - genetics Gene Expression Regulation - physiology Glycosylation Lectins - metabolism Mice Mice, Inbred BALB C Mice, Transgenic Niemann-Pick Disease, Type C - genetics Niemann-Pick Disease, Type C - metabolism Niemann-Pick Disease, Type C - pathology Peptide Fragments - genetics Peptide Fragments - metabolism Polysaccharides - metabolism Proteins - genetics
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