Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

Neurotrophins such as NGF promote neuronal survival and differentiation via the cell surface TrkA neurotrophin receptor. Compounds with neurotrophic actions that are low in molecular weight and can permeate the blood–brain barrier are promising therapeutic agents against neurodegenerative diseases s...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2010-01, Vol.147 (1), p.73-81
Hauptverfasser:	Kosaka, Kunio, Mimura, Junsei, Itoh, Ken, Satoh, Takumi, Shimojo, Yosuke, Kitajima, Chieko, Maruyama, Atsushi, Yamamoto, Masayuki, Shirasawa, Takuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals carnosic acid Cell Differentiation - drug effects Cells, Cultured Diterpenes, Abietane - pharmacology Heat-Shock Proteins - antagonists & inhibitors Heat-Shock Proteins - metabolism Neurites - drug effects Neurites - physiology NF-E2-Related Factor 2 - metabolism Nrf2 p62 PC12 PC12 Cells Plant Extracts - pharmacology Rats Receptor, trkA - metabolism rosemary Sequestosome-1 Protein
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