Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms A Multicenter Study in Korea
To assess the precise mechanisms of stroke in cancer patients, we analyzed the data for cancer patients with acute ischemic stroke registered from 6 centers in South Korea. Clinical features, risk factors, diffusion-weighted imaging lesion patterns, and laboratory findings including D-dimer levels w...
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| Veröffentlicht in: | Stroke (1970) 2010-04, Vol.41 (4), p.798-801 |
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| container_title | Stroke (1970) |
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| creator | SEON GYEONG KIM JI MAN HONG HAHN YOUNG KIM LEE, Jun CHUNG, Pil-Wook PARK, Kwang-Yeol KIM, Gyeong-Moon KWANG HO LEE CHUNG, Chin-Sang OH YOUNG BANG |
| description | To assess the precise mechanisms of stroke in cancer patients, we analyzed the data for cancer patients with acute ischemic stroke registered from 6 centers in South Korea. Clinical features, risk factors, diffusion-weighted imaging lesion patterns, and laboratory findings including D-dimer levels were compared between patients with conventional stroke mechanisms (CSMs) and cryptogenic group.
A total of 161 patients were included in this study: 97 (60.2%) patients in the CSM group and 64 (39.8%) in the cryptogenic group. Patients in the CSM group were older and vascular risk factors were more prevalent than in the cryptogenic group. Diffusion-weighted imaging patterns of multiple lesions involving multiple arterial territories were observed more frequently in the cryptogenic group than in the CSM group. In addition, levels of the D-dimer were higher in the cryptogenic group than in the CSM group (11.5+/-14.6 versus 3.6+/-10.3 microg/dL). In multivariate analysis, the diffusion-weighted imaging lesion pattern of multiple vascular territories (odds ratio, 11.2; 95% CI, 3.74 to 33.3), and D-dimer levels of >1.11 microg/dL (odds ratio, 10.6; 95% CI, 3.29 to 33.8) were associated independently with the cryptogenic group.
Stroke outside of CSM occurred in a large number in cancer patients. In stroke patients with cancer, d-dimer levels and diffusion-weighted imaging lesion patterns may be helpful in early identification of non-CSMs (especially coagulopathy associated with cancer) and possibly in guiding preventive strategies for stroke. |
| doi_str_mv | 10.1161/STROKEAHA.109.571356 |
| format | Article |
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A total of 161 patients were included in this study: 97 (60.2%) patients in the CSM group and 64 (39.8%) in the cryptogenic group. Patients in the CSM group were older and vascular risk factors were more prevalent than in the cryptogenic group. Diffusion-weighted imaging patterns of multiple lesions involving multiple arterial territories were observed more frequently in the cryptogenic group than in the CSM group. In addition, levels of the D-dimer were higher in the cryptogenic group than in the CSM group (11.5+/-14.6 versus 3.6+/-10.3 microg/dL). In multivariate analysis, the diffusion-weighted imaging lesion pattern of multiple vascular territories (odds ratio, 11.2; 95% CI, 3.74 to 33.3), and D-dimer levels of >1.11 microg/dL (odds ratio, 10.6; 95% CI, 3.29 to 33.8) were associated independently with the cryptogenic group.
Stroke outside of CSM occurred in a large number in cancer patients. In stroke patients with cancer, d-dimer levels and diffusion-weighted imaging lesion patterns may be helpful in early identification of non-CSMs (especially coagulopathy associated with cancer) and possibly in guiding preventive strategies for stroke.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.109.571356</identifier><identifier>PMID: 20150545</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Brain Ischemia - epidemiology ; Brain Ischemia - etiology ; Brain Ischemia - pathology ; Brain Ischemia - physiopathology ; Cerebrovascular Circulation - physiology ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasms - complications ; Neoplasms - pathology ; Neoplasms - physiopathology ; Nervous system (semeiology, syndromes) ; Neurology ; Prospective Studies ; Registries ; Republic of Korea ; Risk Factors ; Stroke - epidemiology ; Stroke - etiology ; Stroke - pathology ; Stroke - physiopathology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2010-04, Vol.41 (4), p.798-801</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-55b2e8965b0ee1314b3caf4375e96777eff8b803380d6cdff0f7dc2042989ee53</citedby><cites>FETCH-LOGICAL-c336t-55b2e8965b0ee1314b3caf4375e96777eff8b803380d6cdff0f7dc2042989ee53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22728176$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20150545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SEON GYEONG KIM</creatorcontrib><creatorcontrib>JI MAN HONG</creatorcontrib><creatorcontrib>HAHN YOUNG KIM</creatorcontrib><creatorcontrib>LEE, Jun</creatorcontrib><creatorcontrib>CHUNG, Pil-Wook</creatorcontrib><creatorcontrib>PARK, Kwang-Yeol</creatorcontrib><creatorcontrib>KIM, Gyeong-Moon</creatorcontrib><creatorcontrib>KWANG HO LEE</creatorcontrib><creatorcontrib>CHUNG, Chin-Sang</creatorcontrib><creatorcontrib>OH YOUNG BANG</creatorcontrib><title>Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms A Multicenter Study in Korea</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>To assess the precise mechanisms of stroke in cancer patients, we analyzed the data for cancer patients with acute ischemic stroke registered from 6 centers in South Korea. Clinical features, risk factors, diffusion-weighted imaging lesion patterns, and laboratory findings including D-dimer levels were compared between patients with conventional stroke mechanisms (CSMs) and cryptogenic group.
A total of 161 patients were included in this study: 97 (60.2%) patients in the CSM group and 64 (39.8%) in the cryptogenic group. Patients in the CSM group were older and vascular risk factors were more prevalent than in the cryptogenic group. Diffusion-weighted imaging patterns of multiple lesions involving multiple arterial territories were observed more frequently in the cryptogenic group than in the CSM group. In addition, levels of the D-dimer were higher in the cryptogenic group than in the CSM group (11.5+/-14.6 versus 3.6+/-10.3 microg/dL). In multivariate analysis, the diffusion-weighted imaging lesion pattern of multiple vascular territories (odds ratio, 11.2; 95% CI, 3.74 to 33.3), and D-dimer levels of >1.11 microg/dL (odds ratio, 10.6; 95% CI, 3.29 to 33.8) were associated independently with the cryptogenic group.
Stroke outside of CSM occurred in a large number in cancer patients. In stroke patients with cancer, d-dimer levels and diffusion-weighted imaging lesion patterns may be helpful in early identification of non-CSMs (especially coagulopathy associated with cancer) and possibly in guiding preventive strategies for stroke.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - epidemiology</subject><subject>Brain Ischemia - etiology</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - physiopathology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Republic of Korea</subject><subject>Risk Factors</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Stroke - pathology</subject><subject>Stroke - physiopathology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMlKBDEQhoMoOi5vIJKLeOoxS6eTHIfBDRXFUTw26XSFifaiSVrw7W2dUU9VVH1_FXwIHVIypbSgp4vHh7vrs9nlbEqJngpJuSg20IQKlmd5wdQmmhDCdcZyrXfQbowvhBDGldhGO4xQQUQuJmh5Fe0SWm_xIoX-FbDv8Nx0FgK-N8lDlyJ-9mmJTVf_NP2Q8LzvPsaN7zvT4FuwS9P52EY8w7dDk7wdd2N-kYb68_vedR_A7KMtZ5oIB-u6h57Ozx7nl9nN3cXVfHaTWc6LlAlRMVC6EBUBoJzmFbfG5VwK0IWUEpxTlSKcK1IXtnaOOFlbRnKmlQYQfA-drO6-hf59gJjK1kcLTWM66IdYSs6FkkKTkcxXpA19jAFc-RZ8a8JnSUn5rbj8UzxOdLlSPMaO1g-GqoX6L_TrdASO14CJ1jQujDp9_OeYZIrKgn8BCImFZg</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>SEON GYEONG KIM</creator><creator>JI MAN HONG</creator><creator>HAHN YOUNG KIM</creator><creator>LEE, Jun</creator><creator>CHUNG, Pil-Wook</creator><creator>PARK, Kwang-Yeol</creator><creator>KIM, Gyeong-Moon</creator><creator>KWANG HO LEE</creator><creator>CHUNG, Chin-Sang</creator><creator>OH YOUNG BANG</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms A Multicenter Study in Korea</title><author>SEON GYEONG KIM ; JI MAN HONG ; HAHN YOUNG KIM ; LEE, Jun ; CHUNG, Pil-Wook ; PARK, Kwang-Yeol ; KIM, Gyeong-Moon ; KWANG HO LEE ; CHUNG, Chin-Sang ; OH YOUNG BANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-55b2e8965b0ee1314b3caf4375e96777eff8b803380d6cdff0f7dc2042989ee53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - epidemiology</topic><topic>Brain Ischemia - etiology</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - physiopathology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Republic of Korea</topic><topic>Risk Factors</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>Stroke - pathology</topic><topic>Stroke - physiopathology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SEON GYEONG KIM</creatorcontrib><creatorcontrib>JI MAN HONG</creatorcontrib><creatorcontrib>HAHN YOUNG KIM</creatorcontrib><creatorcontrib>LEE, Jun</creatorcontrib><creatorcontrib>CHUNG, Pil-Wook</creatorcontrib><creatorcontrib>PARK, Kwang-Yeol</creatorcontrib><creatorcontrib>KIM, Gyeong-Moon</creatorcontrib><creatorcontrib>KWANG HO LEE</creatorcontrib><creatorcontrib>CHUNG, Chin-Sang</creatorcontrib><creatorcontrib>OH YOUNG BANG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SEON GYEONG KIM</au><au>JI MAN HONG</au><au>HAHN YOUNG KIM</au><au>LEE, Jun</au><au>CHUNG, Pil-Wook</au><au>PARK, Kwang-Yeol</au><au>KIM, Gyeong-Moon</au><au>KWANG HO LEE</au><au>CHUNG, Chin-Sang</au><au>OH YOUNG BANG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms A Multicenter Study in Korea</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>41</volume><issue>4</issue><spage>798</spage><epage>801</epage><pages>798-801</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>To assess the precise mechanisms of stroke in cancer patients, we analyzed the data for cancer patients with acute ischemic stroke registered from 6 centers in South Korea. Clinical features, risk factors, diffusion-weighted imaging lesion patterns, and laboratory findings including D-dimer levels were compared between patients with conventional stroke mechanisms (CSMs) and cryptogenic group.
A total of 161 patients were included in this study: 97 (60.2%) patients in the CSM group and 64 (39.8%) in the cryptogenic group. Patients in the CSM group were older and vascular risk factors were more prevalent than in the cryptogenic group. Diffusion-weighted imaging patterns of multiple lesions involving multiple arterial territories were observed more frequently in the cryptogenic group than in the CSM group. In addition, levels of the D-dimer were higher in the cryptogenic group than in the CSM group (11.5+/-14.6 versus 3.6+/-10.3 microg/dL). In multivariate analysis, the diffusion-weighted imaging lesion pattern of multiple vascular territories (odds ratio, 11.2; 95% CI, 3.74 to 33.3), and D-dimer levels of >1.11 microg/dL (odds ratio, 10.6; 95% CI, 3.29 to 33.8) were associated independently with the cryptogenic group.
Stroke outside of CSM occurred in a large number in cancer patients. In stroke patients with cancer, d-dimer levels and diffusion-weighted imaging lesion patterns may be helpful in early identification of non-CSMs (especially coagulopathy associated with cancer) and possibly in guiding preventive strategies for stroke.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20150545</pmid><doi>10.1161/STROKEAHA.109.571356</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Brain Ischemia - epidemiology Brain Ischemia - etiology Brain Ischemia - pathology Brain Ischemia - physiopathology Cerebrovascular Circulation - physiology Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Neoplasms - complications Neoplasms - pathology Neoplasms - physiopathology Nervous system (semeiology, syndromes) Neurology Prospective Studies Registries Republic of Korea Risk Factors Stroke - epidemiology Stroke - etiology Stroke - pathology Stroke - physiopathology Vascular diseases and vascular malformations of the nervous system |
| title | Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms A Multicenter Study in Korea |
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