High sensitivity C-reactive protein: Its correlation with sputum cell counts in bronchial asthma
Summary Background Two major acute-phase proteins were identified in human, C-reactive protein and serum amyloid A. There are 3 types of C-reactive protein assays: conventional C-reactive protein, high sensitivity C-reactive protein and cardiac C-reactive protein. High sensitivity C-reactive protein...
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| Veröffentlicht in: | Respiratory medicine 2009-12, Vol.103 (12), p.1878-1884 |
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| creator | Allam, Mona Hashem Said, Azza Farag El Samie Omran, Ahmed Abd Abd El-Reheim, Dalia Mohammed Kasem, Ahmed Hussein |
| description | Summary Background Two major acute-phase proteins were identified in human, C-reactive protein and serum amyloid A. There are 3 types of C-reactive protein assays: conventional C-reactive protein, high sensitivity C-reactive protein and cardiac C-reactive protein. High sensitivity C-reactive protein assays can detect minor inflammatory changes that could be missed by other indices of inflammation. Induced sputum cell counts are relatively non-invasive, safe and reliable method for identifying the presence and type of airway inflammation in asthmatic patients. Purpose of the work This study was designed to detect the role of serum levels of high sensitivity C-reactive protein in asthmatic patients with or without inhaled corticosteroids treatment. Also to determine the relationship of serum high sensitivity C-reactive protein levels to clinical indices of asthma and inflammatory cell counts in induced sputum. Subjects & Methods Serum high sensitivity C-reactive protein level, pulmonary function tests, body mass index and induced sputum cell counts were estimated in 50 asthmatic patients (26 steroid inhaled and 24 steroid naïve). Fifteen healthy volunteers, who matched in age and sex with the other groups, were used as a control group. Results There was an increase of high sensitivity C-reactive protein in asthmatic patients among both steroid inhaled and steroid naïve patients compared to the healthy controls. Serum high sensitivity C-reactive protein correlated negatively with pulmonary function tests and positively with sputum eosinophil % in both inhaled steroid and steroid naïve groups. Conclusion High sensitivity C-reactive protein is one of the markers of systemic inflammation that can be indirectly reflecting the degree of severity of airway inflammation in bronchial asthma. |
| doi_str_mv | 10.1016/j.rmed.2009.06.020 |
| format | Article |
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There are 3 types of C-reactive protein assays: conventional C-reactive protein, high sensitivity C-reactive protein and cardiac C-reactive protein. High sensitivity C-reactive protein assays can detect minor inflammatory changes that could be missed by other indices of inflammation. Induced sputum cell counts are relatively non-invasive, safe and reliable method for identifying the presence and type of airway inflammation in asthmatic patients. Purpose of the work This study was designed to detect the role of serum levels of high sensitivity C-reactive protein in asthmatic patients with or without inhaled corticosteroids treatment. Also to determine the relationship of serum high sensitivity C-reactive protein levels to clinical indices of asthma and inflammatory cell counts in induced sputum. Subjects & Methods Serum high sensitivity C-reactive protein level, pulmonary function tests, body mass index and induced sputum cell counts were estimated in 50 asthmatic patients (26 steroid inhaled and 24 steroid naïve). Fifteen healthy volunteers, who matched in age and sex with the other groups, were used as a control group. Results There was an increase of high sensitivity C-reactive protein in asthmatic patients among both steroid inhaled and steroid naïve patients compared to the healthy controls. Serum high sensitivity C-reactive protein correlated negatively with pulmonary function tests and positively with sputum eosinophil % in both inhaled steroid and steroid naïve groups. Conclusion High sensitivity C-reactive protein is one of the markers of systemic inflammation that can be indirectly reflecting the degree of severity of airway inflammation in bronchial asthma.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2009.06.020</identifier><identifier>PMID: 19836939</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adrenal Cortex Hormones - therapeutic use ; Adult ; Anti-Asthmatic Agents - therapeutic use ; Asthma ; Asthma - blood ; Asthma - drug therapy ; Biological and medical sciences ; Biomarkers - analysis ; Blood ; Bronchial asthma ; C-Reactive Protein - analysis ; Cell Count ; Chronic obstructive pulmonary disease, asthma ; Conflicts of interest ; Diabetes ; Drug therapy ; Eosinophils - metabolism ; Epidemiologic Methods ; Family medical history ; Forced Expiratory Flow Rates - physiology ; Forced Expiratory Volume - physiology ; High sensitivity – C-reactive protein ; Humans ; Lymphocytes - metabolism ; Macrophages - metabolism ; Medical sciences ; Middle Aged ; Neutrophils - metabolism ; Pneumology ; Proteins ; Pulmonary function tests ; Pulmonary/Respiratory ; Sputum - cytology ; Sputum cell counts ; Vital Capacity - physiology</subject><ispartof>Respiratory medicine, 2009-12, Vol.103 (12), p.1878-1884</ispartof><rights>2009</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Limited Dec 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-8cf0150e442c9ee5f26821a7007dfd4f65543694c20662a4a53259e9410abb0b3</citedby><cites>FETCH-LOGICAL-c512t-8cf0150e442c9ee5f26821a7007dfd4f65543694c20662a4a53259e9410abb0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611109002145$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22167405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19836939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allam, Mona Hashem</creatorcontrib><creatorcontrib>Said, Azza Farag</creatorcontrib><creatorcontrib>El Samie Omran, Ahmed Abd</creatorcontrib><creatorcontrib>Abd El-Reheim, Dalia Mohammed</creatorcontrib><creatorcontrib>Kasem, Ahmed Hussein</creatorcontrib><title>High sensitivity C-reactive protein: Its correlation with sputum cell counts in bronchial asthma</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary Background Two major acute-phase proteins were identified in human, C-reactive protein and serum amyloid A. There are 3 types of C-reactive protein assays: conventional C-reactive protein, high sensitivity C-reactive protein and cardiac C-reactive protein. High sensitivity C-reactive protein assays can detect minor inflammatory changes that could be missed by other indices of inflammation. Induced sputum cell counts are relatively non-invasive, safe and reliable method for identifying the presence and type of airway inflammation in asthmatic patients. Purpose of the work This study was designed to detect the role of serum levels of high sensitivity C-reactive protein in asthmatic patients with or without inhaled corticosteroids treatment. Also to determine the relationship of serum high sensitivity C-reactive protein levels to clinical indices of asthma and inflammatory cell counts in induced sputum. Subjects & Methods Serum high sensitivity C-reactive protein level, pulmonary function tests, body mass index and induced sputum cell counts were estimated in 50 asthmatic patients (26 steroid inhaled and 24 steroid naïve). Fifteen healthy volunteers, who matched in age and sex with the other groups, were used as a control group. Results There was an increase of high sensitivity C-reactive protein in asthmatic patients among both steroid inhaled and steroid naïve patients compared to the healthy controls. Serum high sensitivity C-reactive protein correlated negatively with pulmonary function tests and positively with sputum eosinophil % in both inhaled steroid and steroid naïve groups. Conclusion High sensitivity C-reactive protein is one of the markers of systemic inflammation that can be indirectly reflecting the degree of severity of airway inflammation in bronchial asthma.</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adult</subject><subject>Anti-Asthmatic Agents - therapeutic use</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Blood</subject><subject>Bronchial asthma</subject><subject>C-Reactive Protein - analysis</subject><subject>Cell Count</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Conflicts of interest</subject><subject>Diabetes</subject><subject>Drug therapy</subject><subject>Eosinophils - metabolism</subject><subject>Epidemiologic Methods</subject><subject>Family medical history</subject><subject>Forced Expiratory Flow Rates - physiology</subject><subject>Forced Expiratory Volume - physiology</subject><subject>High sensitivity – C-reactive protein</subject><subject>Humans</subject><subject>Lymphocytes - metabolism</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophils - metabolism</subject><subject>Pneumology</subject><subject>Proteins</subject><subject>Pulmonary function tests</subject><subject>Pulmonary/Respiratory</subject><subject>Sputum - cytology</subject><subject>Sputum cell counts</subject><subject>Vital Capacity - physiology</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ktGL1DAQxoN4eOvpP-CDFER8am-SJtlGRJBFvYMDH9TnmKZTN2ubrkl6sv_9pexywj3cUxjm902--RhCXlGoKFB5uavCiF3FAFQFsgIGT8iKipqVNUj-lKxACV5KSuk5eR7jDjLIOTwj51Q1tVS1WpFfV-73tojoo0vu1qVDsSkDGpsLLPZhSuj8--I6xcJOIeBgkpt88c-lLNrPaR4Li8OQm7PPjPNFGyZvt84MhYlpO5oX5Kw3Q8SXp_eC_Pzy-cfmqrz59vV68-mmtIKyVDa2ByoAOWdWIYqeyYZRswZYd33HeykEz5a5ZSAlM9zkNYVCxSmYtoW2viDvjnOz6b8zxqRHFxdvxuM0R72ua9GAkjyTbx6Qu2kOPpvTFOrshjZMZYodKRumGAP2eh_caMIhQ3qJX-_0Er9e4tcgdY4_i16fRs_t0ruXnPLOwNsTYKI1Qx-Mty7ec4xRueYgMvfhyGGO7NZh0NE69BY7F9Am3U3ucR8fH8jt4LzLP_7BA8b_--rINOjvy6EsdwIKgFEu6jtxGLcN</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Allam, Mona Hashem</creator><creator>Said, Azza Farag</creator><creator>El Samie Omran, Ahmed Abd</creator><creator>Abd El-Reheim, Dalia Mohammed</creator><creator>Kasem, Ahmed Hussein</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>High sensitivity C-reactive protein: Its correlation with sputum cell counts in bronchial asthma</title><author>Allam, Mona Hashem ; Said, Azza Farag ; El Samie Omran, Ahmed Abd ; Abd El-Reheim, Dalia Mohammed ; Kasem, Ahmed Hussein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-8cf0150e442c9ee5f26821a7007dfd4f65543694c20662a4a53259e9410abb0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adult</topic><topic>Anti-Asthmatic Agents - therapeutic use</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Blood</topic><topic>Bronchial asthma</topic><topic>C-Reactive Protein - analysis</topic><topic>Cell Count</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Conflicts of interest</topic><topic>Diabetes</topic><topic>Drug therapy</topic><topic>Eosinophils - metabolism</topic><topic>Epidemiologic Methods</topic><topic>Family medical history</topic><topic>Forced Expiratory Flow Rates - physiology</topic><topic>Forced Expiratory Volume - physiology</topic><topic>High sensitivity – C-reactive protein</topic><topic>Humans</topic><topic>Lymphocytes - metabolism</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophils - metabolism</topic><topic>Pneumology</topic><topic>Proteins</topic><topic>Pulmonary function tests</topic><topic>Pulmonary/Respiratory</topic><topic>Sputum - cytology</topic><topic>Sputum cell counts</topic><topic>Vital Capacity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allam, Mona Hashem</creatorcontrib><creatorcontrib>Said, Azza Farag</creatorcontrib><creatorcontrib>El Samie Omran, Ahmed Abd</creatorcontrib><creatorcontrib>Abd El-Reheim, Dalia Mohammed</creatorcontrib><creatorcontrib>Kasem, Ahmed Hussein</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allam, Mona Hashem</au><au>Said, Azza Farag</au><au>El Samie Omran, Ahmed Abd</au><au>Abd El-Reheim, Dalia Mohammed</au><au>Kasem, Ahmed Hussein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High sensitivity C-reactive protein: Its correlation with sputum cell counts in bronchial asthma</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>103</volume><issue>12</issue><spage>1878</spage><epage>1884</epage><pages>1878-1884</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary Background Two major acute-phase proteins were identified in human, C-reactive protein and serum amyloid A. There are 3 types of C-reactive protein assays: conventional C-reactive protein, high sensitivity C-reactive protein and cardiac C-reactive protein. High sensitivity C-reactive protein assays can detect minor inflammatory changes that could be missed by other indices of inflammation. Induced sputum cell counts are relatively non-invasive, safe and reliable method for identifying the presence and type of airway inflammation in asthmatic patients. Purpose of the work This study was designed to detect the role of serum levels of high sensitivity C-reactive protein in asthmatic patients with or without inhaled corticosteroids treatment. Also to determine the relationship of serum high sensitivity C-reactive protein levels to clinical indices of asthma and inflammatory cell counts in induced sputum. Subjects & Methods Serum high sensitivity C-reactive protein level, pulmonary function tests, body mass index and induced sputum cell counts were estimated in 50 asthmatic patients (26 steroid inhaled and 24 steroid naïve). Fifteen healthy volunteers, who matched in age and sex with the other groups, were used as a control group. Results There was an increase of high sensitivity C-reactive protein in asthmatic patients among both steroid inhaled and steroid naïve patients compared to the healthy controls. Serum high sensitivity C-reactive protein correlated negatively with pulmonary function tests and positively with sputum eosinophil % in both inhaled steroid and steroid naïve groups. Conclusion High sensitivity C-reactive protein is one of the markers of systemic inflammation that can be indirectly reflecting the degree of severity of airway inflammation in bronchial asthma.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19836939</pmid><doi>10.1016/j.rmed.2009.06.020</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenal Cortex Hormones - therapeutic use Adult Anti-Asthmatic Agents - therapeutic use Asthma Asthma - blood Asthma - drug therapy Biological and medical sciences Biomarkers - analysis Blood Bronchial asthma C-Reactive Protein - analysis Cell Count Chronic obstructive pulmonary disease, asthma Conflicts of interest Diabetes Drug therapy Eosinophils - metabolism Epidemiologic Methods Family medical history Forced Expiratory Flow Rates - physiology Forced Expiratory Volume - physiology High sensitivity – C-reactive protein Humans Lymphocytes - metabolism Macrophages - metabolism Medical sciences Middle Aged Neutrophils - metabolism Pneumology Proteins Pulmonary function tests Pulmonary/Respiratory Sputum - cytology Sputum cell counts Vital Capacity - physiology |
| title | High sensitivity C-reactive protein: Its correlation with sputum cell counts in bronchial asthma |
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