Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells
Wound healing is a complex process that includes inflammation, tissue formation, and remodeling. While wound healing is accompanied by inflammatory reactions, chronic inflammation impairs acute wound healing. In this study, we investigated whether anthocyanins from black soybean seed coats could sti...
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| Veröffentlicht in: | Food and chemical toxicology 2009-11, Vol.47 (11), p.2806-2812 |
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| creator | Nizamutdinova, Irina Tsoy Kim, Young Min Chung, Jong Il Shin, Sung Chul Jeong, Yong-Kee Seo, Han Geuk Lee, Jae Heun Chang, Ki Churl Kim, Hye Jung |
| description | Wound healing is a complex process that includes inflammation, tissue formation, and remodeling. While wound healing is accompanied by inflammatory reactions, chronic inflammation impairs acute wound healing. In this study, we investigated whether anthocyanins from black soybean seed coats could stimulate wound healing while preventing excessive inflammation. At 24
h of treatment with anthocyanins, fibroblasts showed a significant increase in migration at 100
μg/mL whereas the migration of keratinocytes increased significantly at 50 and 100
μg/mL compared to control. Treatment of anthocyanins for 48
h significantly stimulated the migration of both human dermal fibroblasts and keratinocytes at 50 and 100
μg/mL concentrations. Treatment of cells with anthocyanins stimulated wound-induced VEGF production in fibroblasts and keratinocytes. However, anthocyanins inhibited ROS accumulation and VEGF production in TNF-α-stimulated endothelial cells. Furthermore, treatment of anthocyanins reduced, in a dose-dependent manner, the adhesion of inflammatory monocytes to endothelial cells. Anthocyanins also blocked both the translocation of nuclear factor-kappa B (NF-κB) p65 into the nucleus and the phosphorylation of the inhibitory factor κBα (IκBα). Thus, treatment with anthocyanins from black soybean seed coats may be a potential therapeutic strategy to promote wound healing and to prevent inflammation in a persistent inflammatory condition. |
| doi_str_mv | 10.1016/j.fct.2009.08.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733579815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0278691509004049</els_id><sourcerecordid>35016430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-cd19b3e88ec579bb8af96a7f32a7216cef8cc861c4ee0bc1651f440cc82dc81c3</originalsourceid><addsrcrecordid>eNqFkc1uEzEUhUcIREvhAdiAN8AqwdfOeDxiVVX8SZVYQNeWx3PdOJ2xg-0U5TF4Y26UCHZlZen4O0dH9zTNS-BL4KDeb5be1aXgvF9yvSTlUXMOupMLJVt43Jxz0emF6qE9a56VsuGcd9Cpp80Z9J2UCtrz5vdlrOvk9jaGWJjPaWbDZN0dK2k_oI2sII7MJVsLKzXMu8lWZL_SLo5sjXYK8ZaFyHwYciJjIczS1x1mW0Ok4IpHZZvxHmMl2E92nuk3xYMT45jqGqdgJ-Zwmsrz5om3U8EXp_eiufn08cfVl8X1t89fry6vF66Vq7pwI_SDRK3RtV0_DNr6XtnOS2E7Acqh185pBW6FyAcHqgW_WnHSxOg0OHnRvDvmbnP6ucNSzRzKoYGNmHbF0IUoWENL5NsHSdnS6VeS_xcUIHjbKUUgHEGXUykZvdnmMNu8N8DNYVqzMTStOUxruDakkOfVKXw3zDj-c5y2JODNCbDF2clnG10ofzkhgFNHSdzrI-dtMvY2E3PzXXCQHDoQQh-SPhwJpPvfB8ymuIDR4RgyUq0xhQeK_gHGWc4R</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21205766</pqid></control><display><type>article</type><title>Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Nizamutdinova, Irina Tsoy ; Kim, Young Min ; Chung, Jong Il ; Shin, Sung Chul ; Jeong, Yong-Kee ; Seo, Han Geuk ; Lee, Jae Heun ; Chang, Ki Churl ; Kim, Hye Jung</creator><creatorcontrib>Nizamutdinova, Irina Tsoy ; Kim, Young Min ; Chung, Jong Il ; Shin, Sung Chul ; Jeong, Yong-Kee ; Seo, Han Geuk ; Lee, Jae Heun ; Chang, Ki Churl ; Kim, Hye Jung</creatorcontrib><description>Wound healing is a complex process that includes inflammation, tissue formation, and remodeling. While wound healing is accompanied by inflammatory reactions, chronic inflammation impairs acute wound healing. In this study, we investigated whether anthocyanins from black soybean seed coats could stimulate wound healing while preventing excessive inflammation. At 24
h of treatment with anthocyanins, fibroblasts showed a significant increase in migration at 100
μg/mL whereas the migration of keratinocytes increased significantly at 50 and 100
μg/mL compared to control. Treatment of anthocyanins for 48
h significantly stimulated the migration of both human dermal fibroblasts and keratinocytes at 50 and 100
μg/mL concentrations. Treatment of cells with anthocyanins stimulated wound-induced VEGF production in fibroblasts and keratinocytes. However, anthocyanins inhibited ROS accumulation and VEGF production in TNF-α-stimulated endothelial cells. Furthermore, treatment of anthocyanins reduced, in a dose-dependent manner, the adhesion of inflammatory monocytes to endothelial cells. Anthocyanins also blocked both the translocation of nuclear factor-kappa B (NF-κB) p65 into the nucleus and the phosphorylation of the inhibitory factor κBα (IκBα). Thus, treatment with anthocyanins from black soybean seed coats may be a potential therapeutic strategy to promote wound healing and to prevent inflammation in a persistent inflammatory condition.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2009.08.016</identifier><identifier>PMID: 19733615</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anthocyanins ; Anthocyanins - chemistry ; Anthocyanins - pharmacology ; anti-inflammatory agents ; antioxidants ; Biological and medical sciences ; Cell Migration Assays ; Cells, Cultured ; endothelial cells ; Endothelial Cells - drug effects ; fibroblasts ; Fibroblasts - drug effects ; Glycine max ; Glycine max - chemistry ; Humans ; Inflammation ; Inflammation - prevention & control ; keratinocytes ; Keratinocytes - drug effects ; Medical sciences ; Molecular Biology ; Plant poisons toxicology ; Reactive Oxygen Species ; ROS ; Seeds - chemistry ; testa ; tissue repair ; Toxicology ; Tumor Necrosis Factor-alpha - pharmacology ; Vascular Endothelial Growth Factor A - metabolism ; vascular endothelial growth factors ; VEGF ; Wound healing</subject><ispartof>Food and chemical toxicology, 2009-11, Vol.47 (11), p.2806-2812</ispartof><rights>2009 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-cd19b3e88ec579bb8af96a7f32a7216cef8cc861c4ee0bc1651f440cc82dc81c3</citedby><cites>FETCH-LOGICAL-c534t-cd19b3e88ec579bb8af96a7f32a7216cef8cc861c4ee0bc1651f440cc82dc81c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691509004049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22103033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19733615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nizamutdinova, Irina Tsoy</creatorcontrib><creatorcontrib>Kim, Young Min</creatorcontrib><creatorcontrib>Chung, Jong Il</creatorcontrib><creatorcontrib>Shin, Sung Chul</creatorcontrib><creatorcontrib>Jeong, Yong-Kee</creatorcontrib><creatorcontrib>Seo, Han Geuk</creatorcontrib><creatorcontrib>Lee, Jae Heun</creatorcontrib><creatorcontrib>Chang, Ki Churl</creatorcontrib><creatorcontrib>Kim, Hye Jung</creatorcontrib><title>Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Wound healing is a complex process that includes inflammation, tissue formation, and remodeling. While wound healing is accompanied by inflammatory reactions, chronic inflammation impairs acute wound healing. In this study, we investigated whether anthocyanins from black soybean seed coats could stimulate wound healing while preventing excessive inflammation. At 24
h of treatment with anthocyanins, fibroblasts showed a significant increase in migration at 100
μg/mL whereas the migration of keratinocytes increased significantly at 50 and 100
μg/mL compared to control. Treatment of anthocyanins for 48
h significantly stimulated the migration of both human dermal fibroblasts and keratinocytes at 50 and 100
μg/mL concentrations. Treatment of cells with anthocyanins stimulated wound-induced VEGF production in fibroblasts and keratinocytes. However, anthocyanins inhibited ROS accumulation and VEGF production in TNF-α-stimulated endothelial cells. Furthermore, treatment of anthocyanins reduced, in a dose-dependent manner, the adhesion of inflammatory monocytes to endothelial cells. Anthocyanins also blocked both the translocation of nuclear factor-kappa B (NF-κB) p65 into the nucleus and the phosphorylation of the inhibitory factor κBα (IκBα). Thus, treatment with anthocyanins from black soybean seed coats may be a potential therapeutic strategy to promote wound healing and to prevent inflammation in a persistent inflammatory condition.</description><subject>Anthocyanins</subject><subject>Anthocyanins - chemistry</subject><subject>Anthocyanins - pharmacology</subject><subject>anti-inflammatory agents</subject><subject>antioxidants</subject><subject>Biological and medical sciences</subject><subject>Cell Migration Assays</subject><subject>Cells, Cultured</subject><subject>endothelial cells</subject><subject>Endothelial Cells - drug effects</subject><subject>fibroblasts</subject><subject>Fibroblasts - drug effects</subject><subject>Glycine max</subject><subject>Glycine max - chemistry</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>keratinocytes</subject><subject>Keratinocytes - drug effects</subject><subject>Medical sciences</subject><subject>Molecular Biology</subject><subject>Plant poisons toxicology</subject><subject>Reactive Oxygen Species</subject><subject>ROS</subject><subject>Seeds - chemistry</subject><subject>testa</subject><subject>tissue repair</subject><subject>Toxicology</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>vascular endothelial growth factors</subject><subject>VEGF</subject><subject>Wound healing</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhUcIREvhAdiAN8AqwdfOeDxiVVX8SZVYQNeWx3PdOJ2xg-0U5TF4Y26UCHZlZen4O0dH9zTNS-BL4KDeb5be1aXgvF9yvSTlUXMOupMLJVt43Jxz0emF6qE9a56VsuGcd9Cpp80Z9J2UCtrz5vdlrOvk9jaGWJjPaWbDZN0dK2k_oI2sII7MJVsLKzXMu8lWZL_SLo5sjXYK8ZaFyHwYciJjIczS1x1mW0Ok4IpHZZvxHmMl2E92nuk3xYMT45jqGqdgJ-Zwmsrz5om3U8EXp_eiufn08cfVl8X1t89fry6vF66Vq7pwI_SDRK3RtV0_DNr6XtnOS2E7Acqh185pBW6FyAcHqgW_WnHSxOg0OHnRvDvmbnP6ucNSzRzKoYGNmHbF0IUoWENL5NsHSdnS6VeS_xcUIHjbKUUgHEGXUykZvdnmMNu8N8DNYVqzMTStOUxruDakkOfVKXw3zDj-c5y2JODNCbDF2clnG10ofzkhgFNHSdzrI-dtMvY2E3PzXXCQHDoQQh-SPhwJpPvfB8ymuIDR4RgyUq0xhQeK_gHGWc4R</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Nizamutdinova, Irina Tsoy</creator><creator>Kim, Young Min</creator><creator>Chung, Jong Il</creator><creator>Shin, Sung Chul</creator><creator>Jeong, Yong-Kee</creator><creator>Seo, Han Geuk</creator><creator>Lee, Jae Heun</creator><creator>Chang, Ki Churl</creator><creator>Kim, Hye Jung</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells</title><author>Nizamutdinova, Irina Tsoy ; Kim, Young Min ; Chung, Jong Il ; Shin, Sung Chul ; Jeong, Yong-Kee ; Seo, Han Geuk ; Lee, Jae Heun ; Chang, Ki Churl ; Kim, Hye Jung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-cd19b3e88ec579bb8af96a7f32a7216cef8cc861c4ee0bc1651f440cc82dc81c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anthocyanins</topic><topic>Anthocyanins - chemistry</topic><topic>Anthocyanins - pharmacology</topic><topic>anti-inflammatory agents</topic><topic>antioxidants</topic><topic>Biological and medical sciences</topic><topic>Cell Migration Assays</topic><topic>Cells, Cultured</topic><topic>endothelial cells</topic><topic>Endothelial Cells - drug effects</topic><topic>fibroblasts</topic><topic>Fibroblasts - drug effects</topic><topic>Glycine max</topic><topic>Glycine max - chemistry</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - prevention & control</topic><topic>keratinocytes</topic><topic>Keratinocytes - drug effects</topic><topic>Medical sciences</topic><topic>Molecular Biology</topic><topic>Plant poisons toxicology</topic><topic>Reactive Oxygen Species</topic><topic>ROS</topic><topic>Seeds - chemistry</topic><topic>testa</topic><topic>tissue repair</topic><topic>Toxicology</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>vascular endothelial growth factors</topic><topic>VEGF</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nizamutdinova, Irina Tsoy</creatorcontrib><creatorcontrib>Kim, Young Min</creatorcontrib><creatorcontrib>Chung, Jong Il</creatorcontrib><creatorcontrib>Shin, Sung Chul</creatorcontrib><creatorcontrib>Jeong, Yong-Kee</creatorcontrib><creatorcontrib>Seo, Han Geuk</creatorcontrib><creatorcontrib>Lee, Jae Heun</creatorcontrib><creatorcontrib>Chang, Ki Churl</creatorcontrib><creatorcontrib>Kim, Hye Jung</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nizamutdinova, Irina Tsoy</au><au>Kim, Young Min</au><au>Chung, Jong Il</au><au>Shin, Sung Chul</au><au>Jeong, Yong-Kee</au><au>Seo, Han Geuk</au><au>Lee, Jae Heun</au><au>Chang, Ki Churl</au><au>Kim, Hye Jung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>47</volume><issue>11</issue><spage>2806</spage><epage>2812</epage><pages>2806-2812</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Wound healing is a complex process that includes inflammation, tissue formation, and remodeling. While wound healing is accompanied by inflammatory reactions, chronic inflammation impairs acute wound healing. In this study, we investigated whether anthocyanins from black soybean seed coats could stimulate wound healing while preventing excessive inflammation. At 24
h of treatment with anthocyanins, fibroblasts showed a significant increase in migration at 100
μg/mL whereas the migration of keratinocytes increased significantly at 50 and 100
μg/mL compared to control. Treatment of anthocyanins for 48
h significantly stimulated the migration of both human dermal fibroblasts and keratinocytes at 50 and 100
μg/mL concentrations. Treatment of cells with anthocyanins stimulated wound-induced VEGF production in fibroblasts and keratinocytes. However, anthocyanins inhibited ROS accumulation and VEGF production in TNF-α-stimulated endothelial cells. Furthermore, treatment of anthocyanins reduced, in a dose-dependent manner, the adhesion of inflammatory monocytes to endothelial cells. Anthocyanins also blocked both the translocation of nuclear factor-kappa B (NF-κB) p65 into the nucleus and the phosphorylation of the inhibitory factor κBα (IκBα). Thus, treatment with anthocyanins from black soybean seed coats may be a potential therapeutic strategy to promote wound healing and to prevent inflammation in a persistent inflammatory condition.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>19733615</pmid><doi>10.1016/j.fct.2009.08.016</doi><tpages>7</tpages></addata></record> |
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| subjects | Anthocyanins Anthocyanins - chemistry Anthocyanins - pharmacology anti-inflammatory agents antioxidants Biological and medical sciences Cell Migration Assays Cells, Cultured endothelial cells Endothelial Cells - drug effects fibroblasts Fibroblasts - drug effects Glycine max Glycine max - chemistry Humans Inflammation Inflammation - prevention & control keratinocytes Keratinocytes - drug effects Medical sciences Molecular Biology Plant poisons toxicology Reactive Oxygen Species ROS Seeds - chemistry testa tissue repair Toxicology Tumor Necrosis Factor-alpha - pharmacology Vascular Endothelial Growth Factor A - metabolism vascular endothelial growth factors VEGF Wound healing |
| title | Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells |
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