Classification of HER2 Receptor Status in Breast Cancer Tissues by MALDI Imaging Mass Spectrometry

Clinical laboratory testing for HER2 status in breast cancer tissues is critically important for therapeutic decision making. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful tool for investigating proteins through the direct and morphology-driven ana...

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Veröffentlicht in:	Journal of proteome research 2010-04, Vol.9 (4), p.1854-1863
Hauptverfasser:	Rauser, Sandra, Marquardt, Claudio, Balluff, Benjamin, Deininger, Sören-Oliver, Albers, Christian, Belau, Eckhard, Hartmer, Ralf, Suckau, Detlev, Specht, Katja, Ebert, Matthias Philip, Schmitt, Manfred, Aubele, Michaela, Höfler, Heinz, Walch, Axel
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biomarkers, Tumor - chemistry Biomarkers, Tumor - metabolism Breast Neoplasms - chemistry Breast Neoplasms - enzymology Carrier Proteins Cluster Analysis Female Histocytochemistry Humans LIM Domain Proteins Peptide Fragments - chemistry Peptide Fragments - metabolism Proteomics - methods Receptor, ErbB-2 - chemistry Receptor, ErbB-2 - metabolism Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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