Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs

The total syntheses of natural product rhuschalcone VI and eight analogs employing the Suzuki–Miyaura reaction are reported together with antiprotozoal activities and cytotoxicity data for some of them. The total synthesis of a potent antiplasmodial natural bichalcone, rhuschalcone VI, is described...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2010-04, Vol.18 (7), p.2464-2473
Hauptverfasser:	Mihigo, Shetonde O., Mammo, Wendimagegn, Bezabih, Merhatibeb, Andrae-Marobela, Kerstin, Abegaz, Berhanu M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - pharmacology Antiprotozoal activities Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - pharmacology Bichalcone Bodo caudatus Chalcone - analogs & derivatives Chalcone - chemical synthesis Chalcone - pharmacology Indicators and Reagents Leishmania - drug effects Lethal Dose 50 Magnetic Resonance Spectroscopy Plant Bark - chemistry Rhus - chemistry Rhuschalcone Suzuki–Miyaura reaction Trypanocidal Agents - chemical synthesis Trypanocidal Agents - pharmacology Trypanosoma brucei brucei - drug effects Trypanosoma cruzi - drug effects
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