Ethanol and Δ-sleep-inducing peptide: Effects on brain monoamines
The brain content of dopamine (DA) and its metabolites [dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)] were the same in rats with different immobilization times in forced swimming test, while the serotonin (5-HT) concentration was higher in high active (HA, immobilization < 2 min...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1992-11, Vol.43 (3), p.683-687 |
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| creator | Yukhananov, R.Y. Tennilä, T.M.-L. Miroshnicenko, T.I. Kudrin, V.S. Ushakov, A.N. Melnik, E.I. Michaleva, I.I. Rayevsky, K.S. Airaksinen, M.M. Maisky, A.I. |
| description | The brain content of dopamine (DA) and its metabolites [dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)] were the same in rats with different immobilization times in forced swimming test, while the serotonin (5-HT) concentration was higher in high active (HA, immobilization < 2 min) than low active (LA, immobilization > 5 min) animals. Ethanol (2 g/kg, PO) tended to increase the DA level in the striatum and nucleus accumbens in LA rats and decrease the 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentration in HA rats. Δ-Sleep-inducing peptide (DSIP) injection reduced the level of 5-HT in the medial prefrontal cortex (MFC) in both groups, did not affect the concentration of DA or DOPAC, but increased HVA in the striatum of HA rats. DSIP injected before ethanol administration augmented the ethanol effects on 5-HT in the MFC and attenuated the action of ethanol on 5-HIAA in the nucleus accumbens. A relationship between the different levels of voluntary alcohol consumption and sensitivity to stress among LA and HA rats and the differences in DA and 5-HT concentration is suggested. The use of LA and HA rats in developing models for testing of stress-shielding compounds is also described. |
| doi_str_mv | 10.1016/0091-3057(92)90396-W |
| format | Article |
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Ethanol (2 g/kg, PO) tended to increase the DA level in the striatum and nucleus accumbens in LA rats and decrease the 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentration in HA rats. Δ-Sleep-inducing peptide (DSIP) injection reduced the level of 5-HT in the medial prefrontal cortex (MFC) in both groups, did not affect the concentration of DA or DOPAC, but increased HVA in the striatum of HA rats. DSIP injected before ethanol administration augmented the ethanol effects on 5-HT in the MFC and attenuated the action of ethanol on 5-HIAA in the nucleus accumbens. A relationship between the different levels of voluntary alcohol consumption and sensitivity to stress among LA and HA rats and the differences in DA and 5-HT concentration is suggested. 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Ethanol (2 g/kg, PO) tended to increase the DA level in the striatum and nucleus accumbens in LA rats and decrease the 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentration in HA rats. Δ-Sleep-inducing peptide (DSIP) injection reduced the level of 5-HT in the medial prefrontal cortex (MFC) in both groups, did not affect the concentration of DA or DOPAC, but increased HVA in the striatum of HA rats. DSIP injected before ethanol administration augmented the ethanol effects on 5-HT in the MFC and attenuated the action of ethanol on 5-HIAA in the nucleus accumbens. A relationship between the different levels of voluntary alcohol consumption and sensitivity to stress among LA and HA rats and the differences in DA and 5-HT concentration is suggested. 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Ethanol (2 g/kg, PO) tended to increase the DA level in the striatum and nucleus accumbens in LA rats and decrease the 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentration in HA rats. Δ-Sleep-inducing peptide (DSIP) injection reduced the level of 5-HT in the medial prefrontal cortex (MFC) in both groups, did not affect the concentration of DA or DOPAC, but increased HVA in the striatum of HA rats. DSIP injected before ethanol administration augmented the ethanol effects on 5-HT in the MFC and attenuated the action of ethanol on 5-HIAA in the nucleus accumbens. A relationship between the different levels of voluntary alcohol consumption and sensitivity to stress among LA and HA rats and the differences in DA and 5-HT concentration is suggested. The use of LA and HA rats in developing models for testing of stress-shielding compounds is also described.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1448465</pmid><doi>10.1016/0091-3057(92)90396-W</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1992-11, Vol.43 (3), p.683-687 |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Alcohol Drinking Alcoholism and acute alcohol poisoning Animals Biogenic Monoamines - metabolism Biological and medical sciences Brain Chemistry - drug effects Chromatography, High Pressure Liquid Corpus Striatum - drug effects Corpus Striatum - metabolism Delta Sleep-Inducing Peptide - pharmacology Dopamine - metabolism DSIP Electrochemistry Ethanol Ethanol - pharmacology Homovanillic Acid - metabolism Limbic system Male Medical sciences Monoamines Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Serotonin - metabolism Stress, Psychological - metabolism Toxicology |
| title | Ethanol and Δ-sleep-inducing peptide: Effects on brain monoamines |
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