Prognostic significance of the immunohistochemical expression of O6-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas

We studied the expression of O6‐methylguanine‐DNA methyltransferase (O6‐MGMT), P‐glycoprotein (Pgp), and multidrug resistance protein‐1 (MRP‐1) in 23 glioblastomas using RT‐PCR, methylation‐specific PCR, and immunohistochemistry, and analyzed their association with overall patient survival. Univaria...

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Veröffentlicht in:	Neuropathology 2009-08, Vol.29 (4), p.379-388
Hauptverfasser:	Nakagawa, Takao, Ido, Kazunori, Sakuma, Takahiro, Takeuchi, Hiroaki, Sato, Kazufumi, Kubota, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Brain Neoplasms - diagnosis Brain Neoplasms - enzymology Brain Neoplasms - genetics Brain Neoplasms - metabolism Female Gene Expression Regulation, Neoplastic glioblastoma Glioblastoma - diagnosis Glioblastoma - enzymology Glioblastoma - genetics Glioblastoma - metabolism Humans Immunohistochemistry Male Middle Aged MRP-1 O-Methylguanine-DNA Methyltransferase - biosynthesis O-Methylguanine-DNA Methyltransferase - genetics O6-MGMT P-glycoprotein Predictive Value of Tests Prognosis Young Adult
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