Autophagic degradation of nuclear components in mammalian cells

Autophagy is an evolutionally conserved intracellular mechanism for the degradation of organelles and proteins. Here we demonstrate the presence of perinuclear autophagosomes/autolysosomes containing nuclear components in nuclear envelopathies caused by mutations in the genes encoding A-type lamins...

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Veröffentlicht in:	Autophagy 2009-08, Vol.5 (6), p.795-804
Hauptverfasser:	Park, Young-Eun, Hayashi, Yukiko K., Bonne, Gisèle, Arimura, Takuro, Noguchi, Satoru, Nonaka, Ikuya, Nishino, Ichizo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Binding Biology Bioscience Calcium Cancer Cell Cell Nucleus - metabolism Cell Nucleus - ultrastructure Cell Survival Cells, Cultured Cycle Embryo, Mammalian - cytology Fibroblasts - metabolism Fibroblasts - ultrastructure Green Fluorescent Proteins - metabolism Humans Lamin Type A - metabolism Landes Lysosomal-Associated Membrane Protein 2 - metabolism Mice Microtubule-Associated Proteins - metabolism Muscle, Skeletal - pathology Muscle, Skeletal - ultrastructure Mutant Proteins - metabolism Myocardium - pathology Myocardium - ultrastructure Nuclear Envelope - metabolism Nuclear Envelope - pathology Nuclear Envelope - ultrastructure Organelle Shape Organogenesis Phagosomes - metabolism Phagosomes - ultrastructure Proteins Recombinant Fusion Proteins - metabolism Skin - pathology Transcription, Genetic Vacuoles - metabolism Vacuoles - ultrastructure
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