Expression of excision repair cross-complementation group 1 protein predicts poor outcome in advanced non-small cell lung cancer patients treated with platinum-based doublet chemotherapy

Abstract Backgroud Alterations in apoptosis and DNA damage repair related proteins are associated with resistance to chemotherapy, which is the most important cause of treatment failure in advanced non-small cell lung cancer (NSCLC). Patients and methods Pretreatment tumor biopsy specimens from 50 p...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2009-09, Vol.65 (3), p.377-382
Hauptverfasser:	Lee, Hyun Woo, Choi, Yong-Won, Han, Jae Ho, Kim, Jang Hee, Jung, Jae Ho, Jeong, Seong Hyun, Kang, Seok Yun, Choi, Jin-Hyuk, Oh, Young Taek, Park, Kwang Joo, Hwang, Sung Chul, Sheen, Seung Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biological and medical sciences Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - physiopathology Chemotherapy Cisplatin - administration & dosage Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Disease Progression DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm Endonucleases - genetics Endonucleases - metabolism ERCC1 Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - physiopathology Male Medical sciences Middle Aged Neoplasm Staging Platinum - administration & dosage Pleural Effusion, Malignant - diagnosis Pleural Effusion, Malignant - drug therapy Pleural Effusion, Malignant - mortality Pleural Effusion, Malignant - pathology Pleural Effusion, Malignant - physiopathology Pneumology Prognosis Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Pulmonary/Respiratory Recurrence Survival Analysis Treatment Outcome Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Tumors of the respiratory system and mediastinum
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