Loss of Etv5 Decreases Proliferation and RET Levels in Neonatal Mouse Testicular Germ Cells and Causes an Abnormal First Wave of Spermatogenesis

Mice that are ets variant gene 5 (ETV5) null (Etv5⁻/⁻) undergo the first wave of spermatogenesis but lose all spermatogonial stem cells (SSCs) during this time. The SSC loss in Etv5⁻/⁻ mice begins during the neonatal period, suggesting a role for ETV5 in SSC self-renewal during this period. Herein,...

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Veröffentlicht in:	Biology of reproduction 2009-08, Vol.81 (2), p.258-266
Hauptverfasser:	Tyagi, Gaurav, Carnes, Kay, Morrow, Carla, Kostereva, Natalia V, Ekman, Gail C, Meling, Daryl D, Hostetler, Chris, Griswold, Michael, Murphy, Kenneth M, Hess, Rex A, Hofmann, Marie-Claude, Cooke, Paul S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cell Proliferation Cells, Cultured DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fibroblast Growth Factor 2 - administration & dosage Fibroblast Growth Factor 2 - metabolism Gene Expression Regulation, Developmental Germ Cells - cytology Germ Cells - metabolism Germ Cells - transplantation Glial Cell Line-Derived Neurotrophic Factor - administration & dosage Glial Cell Line-Derived Neurotrophic Factor Receptors - administration & dosage Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism Immunohistochemistry Male Mice Mice, Knockout Microdissection Proto-Oncogene Proteins c-ret - genetics Proto-Oncogene Proteins c-ret - metabolism Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - metabolism RNA, Messenger - metabolism Sertoli Cells - cytology Sertoli Cells - metabolism Spermatogenesis - genetics Spermatogonia - cytology Spermatogonia - metabolism Testis - embryology Testis - growth & development Testis - metabolism Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism
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