Empirical and theoretical phenotypic discrimination
We have developed an integrated approach that combines empirical and computational methodologies to define an individual’s thrombin phenotype. We have evaluated the process of thrombin generation in healthy individuals and individuals with defined pathologies in order to develop general criteria rel...
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| Veröffentlicht in: | Journal of thrombosis and haemostasis 2009-07, Vol.7, p.181-186 |
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| container_title | Journal of thrombosis and haemostasis |
| container_volume | 7 |
| creator | BRUMMEL‐ZIEDINS, K. E. ORFEO, T. ROSENDAAL, F. R. UNDAS, A. RIVARD, G. E. BUTENAS, S. MANN, K. G. |
| description | We have developed an integrated approach that combines empirical and computational methodologies to define an individual’s thrombin phenotype. We have evaluated the process of thrombin generation in healthy individuals and individuals with defined pathologies in order to develop general criteria relevant to assess an individual’s propensity for hemorrhage or thrombosis. Three complementary hypotheses have emerged from our work: (i) compensation by the ensemble of other coagulation proteins in individuals with specific factor deficiencies can ‘normalize’ an individual’s thrombin generation process and represents a rationale for their unexpected phenotype; (ii) individuals with clinically unremarkable factor levels may present thrombin generation profiles typical of individuals with hemostatic complications; and (iii) in some hemostatic disorders a specific pattern of expression of a small ensemble of coagulation factors may be sufficient to explain the overall phenotype. |
| doi_str_mv | 10.1111/j.1538-7836.2009.03426.x |
| format | Article |
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E.</creatorcontrib><creatorcontrib>ORFEO, T.</creatorcontrib><creatorcontrib>ROSENDAAL, F. R.</creatorcontrib><creatorcontrib>UNDAS, A.</creatorcontrib><creatorcontrib>RIVARD, G. E.</creatorcontrib><creatorcontrib>BUTENAS, S.</creatorcontrib><creatorcontrib>MANN, K. G.</creatorcontrib><title>Empirical and theoretical phenotypic discrimination</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>We have developed an integrated approach that combines empirical and computational methodologies to define an individual’s thrombin phenotype. We have evaluated the process of thrombin generation in healthy individuals and individuals with defined pathologies in order to develop general criteria relevant to assess an individual’s propensity for hemorrhage or thrombosis. 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G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Empirical and theoretical phenotypic discrimination</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2009-07</date><risdate>2009</risdate><volume>7</volume><spage>181</spage><epage>186</epage><pages>181-186</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>We have developed an integrated approach that combines empirical and computational methodologies to define an individual’s thrombin phenotype. We have evaluated the process of thrombin generation in healthy individuals and individuals with defined pathologies in order to develop general criteria relevant to assess an individual’s propensity for hemorrhage or thrombosis. Three complementary hypotheses have emerged from our work: (i) compensation by the ensemble of other coagulation proteins in individuals with specific factor deficiencies can ‘normalize’ an individual’s thrombin generation process and represents a rationale for their unexpected phenotype; (ii) individuals with clinically unremarkable factor levels may present thrombin generation profiles typical of individuals with hemostatic complications; and (iii) in some hemostatic disorders a specific pattern of expression of a small ensemble of coagulation factors may be sufficient to explain the overall phenotype.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19630796</pmid><doi>10.1111/j.1538-7836.2009.03426.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1538-7933 |
| ispartof | Journal of thrombosis and haemostasis, 2009-07, Vol.7, p.181-186 |
| issn | 1538-7933 1538-7836 1538-7836 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | blood coagulation computational Computational Biology empirical Empirical Research Hemorrhage Hemostasis Humans Models, Theoretical Phenotype Thrombin - biosynthesis Thrombin - physiology thrombin generation Thrombosis |
| title | Empirical and theoretical phenotypic discrimination |
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