Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor

Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR. Previously reported short peptide ligands for this receptor either have low potency or lack receptor selectivity. Here we r...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-07, Vol.53 (13), p.4938-4948
Hauptverfasser:	Scully, Conor C. G, Blakeney, Jade S, Singh, Ranee, Hoang, Huy N, Abbenante, Giovanni, Reid, Robert C, Fairlie, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Calcium - metabolism Complement C3a - metabolism Humans Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Receptors, Complement - agonists Receptors, Complement - antagonists & inhibitors Receptors, Complement - metabolism Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship U937 Cells
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