A Strategy for the Determination of the Elemental Composition by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Based on Isotopic Peak Ratios
We propose a novel strategy for determining the elemental composition of organic compounds using the peak ratio of isotopic fine structure observed by high-magnetic field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Using 3′-phosphoadenosine 5′-phosphosulfate and CTU guan...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2010-07, Vol.82 (13), p.5887-5891 |
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| container_issue | 13 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Miura, Daisuke Tsuji, Yukiko Takahashi, Katsutoshi Wariishi, Hiroyuki Saito, Kazunori |
| description | We propose a novel strategy for determining the elemental composition of organic compounds using the peak ratio of isotopic fine structure observed by high-magnetic field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Using 3′-phosphoadenosine 5′-phosphosulfate and CTU guanamine as standard organic compounds, isotopic peaks derived from 15N-, 34S-, and 18O-substituted forms were separated from 13C-substituted species. Furthermore, these isotopic peaks were quantitatively detected and closely matched the natural abundance of each element. These data successfully led us to determine the one elemental composition in a standard independent manner. The approach should be particularly amenable to the metabolomics research field. |
| doi_str_mv | 10.1021/ac902931x |
| format | Article |
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Using 3′-phosphoadenosine 5′-phosphosulfate and CTU guanamine as standard organic compounds, isotopic peaks derived from 15N-, 34S-, and 18O-substituted forms were separated from 13C-substituted species. Furthermore, these isotopic peaks were quantitatively detected and closely matched the natural abundance of each element. These data successfully led us to determine the one elemental composition in a standard independent manner. 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Tsuji, Yukiko ; Takahashi, Katsutoshi ; Wariishi, Hiroyuki ; Saito, Kazunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a437t-a2f0594074d7b48d14dfe3778bba270e705c55edace9fdda030f3ff62c4238333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analytical chemistry</topic><topic>Carbon Isotopes - chemistry</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Fourier Analysis</topic><topic>Fourier transforms</topic><topic>Ions</topic><topic>Ions - chemistry</topic><topic>Isotopes</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Metabolomics - methods</topic><topic>Nitrogen Isotopes - chemistry</topic><topic>Organic Chemicals - chemistry</topic><topic>Oxygen Isotopes - chemistry</topic><topic>Particle accelerators</topic><topic>Phosphoadenosine Phosphosulfate - chemistry</topic><topic>Spectrometric and optical methods</topic><topic>Sulfur Isotopes - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miura, Daisuke</creatorcontrib><creatorcontrib>Tsuji, Yukiko</creatorcontrib><creatorcontrib>Takahashi, Katsutoshi</creatorcontrib><creatorcontrib>Wariishi, Hiroyuki</creatorcontrib><creatorcontrib>Saito, Kazunori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miura, Daisuke</au><au>Tsuji, Yukiko</au><au>Takahashi, Katsutoshi</au><au>Wariishi, Hiroyuki</au><au>Saito, Kazunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Strategy for the Determination of the Elemental Composition by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Based on Isotopic Peak Ratios</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>82</volume><issue>13</issue><spage>5887</spage><epage>5891</epage><pages>5887-5891</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>We propose a novel strategy for determining the elemental composition of organic compounds using the peak ratio of isotopic fine structure observed by high-magnetic field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Using 3′-phosphoadenosine 5′-phosphosulfate and CTU guanamine as standard organic compounds, isotopic peaks derived from 15N-, 34S-, and 18O-substituted forms were separated from 13C-substituted species. Furthermore, these isotopic peaks were quantitatively detected and closely matched the natural abundance of each element. These data successfully led us to determine the one elemental composition in a standard independent manner. The approach should be particularly amenable to the metabolomics research field.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>20521766</pmid><doi>10.1021/ac902931x</doi><tpages>5</tpages></addata></record> |
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| subjects | Analytical chemistry Carbon Isotopes - chemistry Chemistry Exact sciences and technology Fourier Analysis Fourier transforms Ions Ions - chemistry Isotopes Mass spectrometry Mass Spectrometry - methods Metabolomics - methods Nitrogen Isotopes - chemistry Organic Chemicals - chemistry Oxygen Isotopes - chemistry Particle accelerators Phosphoadenosine Phosphosulfate - chemistry Spectrometric and optical methods Sulfur Isotopes - chemistry |
| title | A Strategy for the Determination of the Elemental Composition by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Based on Isotopic Peak Ratios |
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