Characterizing metalloendonuclease mixed metal complexes by global kinetic analysis

To test the role of a secondary metal ion in a two metal ion metallonuclease mechanism, some groups have introduced a nonsupportive metal ion [usually Ca(II)] in cleavage reactions. Stimulation of Mg(II)- or Mn(II)-supported activity has been taken as evidence that the second metal ion is regulatory...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2010-05, Vol.15 (4), p.533-545
Hauptverfasser:	Prasannan, Charulata B, Xie, Fuqian, Dupureur, Cynthia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding affinity Biochemistry Biomedical and Life Sciences Calcium - metabolism Deoxyribonucleases, Type II Site-Specific - chemistry Deoxyribonucleases, Type II Site-Specific - metabolism enzyme kinetics Kinetics Life Sciences Magnesium - metabolism Microbiology nucleic acids Original Paper structure-activity relationships thermodynamics
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