SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation

Previously, we showed that 2B4 is a dominant inhibitory receptor in SHIP-deficient NK cells that prevents efficient cytolysis of complex targets. We show in this study that 2B4 deficiency restores homeostatic control and cytolytic function to SHIP-deficient NK cells. However, 2B4(-/-)SHIP(-/-) NK ce...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-05, Vol.184 (9), p.5065-5074
Hauptverfasser:	Fortenbery, Nicole R, Paraiso, Kim H T, Taniguchi, Masaru, Brooks, Colin, Ibrahim, Leina, Kerr, William G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, CD - physiology CD48 Antigen Cell Lineage - genetics Cell Lineage - immunology Cytotoxicity, Immunologic - genetics Female H-2 Antigens - metabolism H-2 Antigens - physiology Homeostasis - genetics Homeostasis - immunology Inositol Polyphosphate 5-Phosphatases Interferon-gamma - biosynthesis Interferon-gamma - physiology Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ligands Male Mice Mice, Knockout Phosphoric Monoester Hydrolases - deficiency Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phosphoric Monoester Hydrolases - physiology Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Immunologic - physiology Receptors, Natural Killer Cell - biosynthesis Receptors, Natural Killer Cell - metabolism Receptors, Natural Killer Cell - physiology Signal Transduction - genetics Signal Transduction - immunology Signaling Lymphocytic Activation Molecule Family
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