Impairment of Sox9 expression in limb buds of rats homozygous for hypodactyly mutation

Rat hypodactyly (hd) is an autosomal recessive mutation manifesting in homozygotes as reduction or loss of digits II and III. We mapped the hd allele to a short segment of chromosome 10, containing 16 genes. None of these genes has been shown to influence limb development yet. In situ hybridization...

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Veröffentlicht in:	Folia biologica 2010-01, Vol.56 (2), p.58-65
Hauptverfasser:	Liska, F, Snajdr, P, Stricker, S, Gosele, C, Krenová, D, Mundlos, S, Hubner, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning - genetics Bone Morphogenetic Protein Receptors, Type I - genetics Bone Morphogenetic Protein Receptors, Type I - metabolism Embryo, Mammalian - anatomy & histology Embryo, Mammalian - metabolism Extremities Female Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Limb Buds - abnormalities Limb Buds - metabolism Male Mutation Phenotype Rats Rats, Wistar SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism
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