Transcriptional Profiling of Luteinizing Hormone Receptor-Deficient Mice Before and after Testosterone Treatment Provides Insight into the Hormonal Control of Postnatal Testicular Development and Leydig Cell Differentiation

Luteinizing hormone (LH) is a key regulator of male fertility through its effects on testosterone secretion by Leydig cells. Transcriptional control of this is, however, currently poorly understood. Mice in which the LH receptor is knocked out (LuRKO) show reduced testicular size, reduced testostero...

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Veröffentlicht in:	Biology of reproduction 2010-06, Vol.82 (6), p.1139-1150
Hauptverfasser:	Griffin, D.K, Ellis, P.J, Dunmore, B, Bauer, J, Abel, M.H, Affara, N.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation - genetics Fundamental and applied biological sciences. Psychology Gene Expression Profiling Leydig Cells - cytology Leydig Cells - metabolism Luteinizing Hormone - pharmacology Luteinizing Hormone - physiology Male Mice Receptors, LH - genetics Spermatogenesis - genetics Testis - growth & development Testosterone - pharmacology Testosterone - physiology Transcription, Genetic Vertebrates: reproduction
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