Dramatic response of a patient with pregnancy induced idiopathic pulmonary arterial hypertension to sildenafil treatment
Idiopathic pulmonary arterial hypertension (IPAH) is characterized by a progressive increase in pulmonary vascular resistance, which may lead to right ventricular failure and death. Major cardiovascular and pulmonary alterations occur during pregnancy and therefore worsen or increase the complicatio...
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Veröffentlicht in: | The journal of obstetrics and gynaecology research 2010-04, Vol.36 (2), p.414-417 |
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creator | Taçoy, Gülten Ekim, Numan Nadir Çengel, Atiye |
description | Idiopathic pulmonary arterial hypertension (IPAH) is characterized by a progressive increase in pulmonary vascular resistance, which may lead to right ventricular failure and death. Major cardiovascular and pulmonary alterations occur during pregnancy and therefore worsen or increase the complications of pulmonary arterial hypertension (PAH). A patient diagnosed with IPAH after a successful full‐term pregnancy and cesarean section with epidural anesthesia is presented. The postoperative course was complicated by progressive dyspnea, and lower limb edema. The outcome of treatment with sildenafil during puerperium was favorable in this patient. The clinical course was complicated by an unexpected spontaneous pregnancy after primary infertility. |
doi_str_mv | 10.1111/j.1447-0756.2009.01136.x |
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Major cardiovascular and pulmonary alterations occur during pregnancy and therefore worsen or increase the complications of pulmonary arterial hypertension (PAH). A patient diagnosed with IPAH after a successful full‐term pregnancy and cesarean section with epidural anesthesia is presented. The postoperative course was complicated by progressive dyspnea, and lower limb edema. The outcome of treatment with sildenafil during puerperium was favorable in this patient. The clinical course was complicated by an unexpected spontaneous pregnancy after primary infertility.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/j.1447-0756.2009.01136.x</identifier><identifier>PMID: 20492398</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Female ; Humans ; Hypertension, Pregnancy-Induced - drug therapy ; Hypertension, Pulmonary - drug therapy ; idiopathic pulmonary arterial hypertension ; Piperazines - therapeutic use ; Pregnancy ; Purines - therapeutic use ; sildenafil ; Sildenafil Citrate ; Sulfones - therapeutic use ; treatment ; Treatment Outcome ; Vasodilator Agents - therapeutic use</subject><ispartof>The journal of obstetrics and gynaecology research, 2010-04, Vol.36 (2), p.414-417</ispartof><rights>2010 The Authors. 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Major cardiovascular and pulmonary alterations occur during pregnancy and therefore worsen or increase the complications of pulmonary arterial hypertension (PAH). A patient diagnosed with IPAH after a successful full‐term pregnancy and cesarean section with epidural anesthesia is presented. The postoperative course was complicated by progressive dyspnea, and lower limb edema. The outcome of treatment with sildenafil during puerperium was favorable in this patient. The clinical course was complicated by an unexpected spontaneous pregnancy after primary infertility.</description><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - drug therapy</subject><subject>Hypertension, Pulmonary - drug therapy</subject><subject>idiopathic pulmonary arterial hypertension</subject><subject>Piperazines - therapeutic use</subject><subject>Pregnancy</subject><subject>Purines - therapeutic use</subject><subject>sildenafil</subject><subject>Sildenafil Citrate</subject><subject>Sulfones - therapeutic use</subject><subject>treatment</subject><subject>Treatment Outcome</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv3CAUhVGVqnm0fyFil5VdMAw2iyyiJE1TRcqmXSMe1x1GNrhgKzP_PriTZl2ExBGcc674EMKU1LSsr7uact5WpN2IuiFE1oRSJur9B3T2_nBSNOO06kgrTtF5zjtCaCtp9wmdNoTLhsnuDO3vkh717C1OkKcYMuDYY42ncgdhxi9-3uIpwe-ggz1gH9xiwWHvfCyWbclNyzDGoNMB6zRD8nrA28MERYfsY8BzxNkPDoLu_YDnBHoeS_Nn9LHXQ4Yvb-cF-vXt_uft9-rp-eHx9uapsryhouKcSqGFNI3dgCGEc71uK0TTMCY4tY710roeHFBiesKcc0Y4Y6g0phXsAl0de6cU_yyQZzX6bGEYdIC4ZNUyttlIzrvi7I5Om2LOCXo1JT-WjylK1Ipd7dRKV6101Ypd_cWu9iV6-TZkMSO49-A_zsVwfTS8-AEO_12sfjw_rIq9Aj0hlIA</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Taçoy, Gülten</creator><creator>Ekim, Numan Nadir</creator><creator>Çengel, Atiye</creator><general>Blackwell Publishing Asia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Dramatic response of a patient with pregnancy induced idiopathic pulmonary arterial hypertension to sildenafil treatment</title><author>Taçoy, Gülten ; Ekim, Numan Nadir ; Çengel, Atiye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4216-44196a69b2c5eb0044a44a4c662233641cd3f9cdfede10bf03dddb6dbb19bb763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - drug therapy</topic><topic>Hypertension, Pulmonary - drug therapy</topic><topic>idiopathic pulmonary arterial hypertension</topic><topic>Piperazines - therapeutic use</topic><topic>Pregnancy</topic><topic>Purines - therapeutic use</topic><topic>sildenafil</topic><topic>Sildenafil Citrate</topic><topic>Sulfones - therapeutic use</topic><topic>treatment</topic><topic>Treatment Outcome</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taçoy, Gülten</creatorcontrib><creatorcontrib>Ekim, Numan Nadir</creatorcontrib><creatorcontrib>Çengel, Atiye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taçoy, Gülten</au><au>Ekim, Numan Nadir</au><au>Çengel, Atiye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dramatic response of a patient with pregnancy induced idiopathic pulmonary arterial hypertension to sildenafil treatment</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2010-04</date><risdate>2010</risdate><volume>36</volume><issue>2</issue><spage>414</spage><epage>417</epage><pages>414-417</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Idiopathic pulmonary arterial hypertension (IPAH) is characterized by a progressive increase in pulmonary vascular resistance, which may lead to right ventricular failure and death. Major cardiovascular and pulmonary alterations occur during pregnancy and therefore worsen or increase the complications of pulmonary arterial hypertension (PAH). A patient diagnosed with IPAH after a successful full‐term pregnancy and cesarean section with epidural anesthesia is presented. The postoperative course was complicated by progressive dyspnea, and lower limb edema. The outcome of treatment with sildenafil during puerperium was favorable in this patient. The clinical course was complicated by an unexpected spontaneous pregnancy after primary infertility.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>20492398</pmid><doi>10.1111/j.1447-0756.2009.01136.x</doi><tpages>4</tpages></addata></record> |
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subjects | Female Humans Hypertension, Pregnancy-Induced - drug therapy Hypertension, Pulmonary - drug therapy idiopathic pulmonary arterial hypertension Piperazines - therapeutic use Pregnancy Purines - therapeutic use sildenafil Sildenafil Citrate Sulfones - therapeutic use treatment Treatment Outcome Vasodilator Agents - therapeutic use |
title | Dramatic response of a patient with pregnancy induced idiopathic pulmonary arterial hypertension to sildenafil treatment |
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