Induction and Function of FcεRII on YT Cells; Possible Role of ADF/Thioredoxin in FcεRII Expression
The regulation of low-affinity Fc receptor for lgE (FcγRII) and the characteristics of both membrane and soluble forms of FcγRII were studied using YT cell line. We found that YT cells, a human NK like cell line, expressed FcγRII after IL-1 stimulation. Cross-linking of FceRII on IL-1-stimulated YT...
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| Veröffentlicht in: | Immunobiology (1979) 1992-08, Vol.185 (2), p.193-206 |
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| container_title | Immunobiology (1979) |
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| creator | Sorachi, Ken-Ichi Sugie, Katsuji Maekawa, Noriko Takami, Masaaki Kawabe, Takumi Kumagai, Shunichi Imura, Hiroo Yodoi, Junji |
| description | The regulation of low-affinity Fc receptor for lgE (FcγRII) and the characteristics of both membrane and soluble forms of FcγRII were studied using YT cell line. We found that YT cells, a human NK like cell line, expressed FcγRII after IL-1 stimulation. Cross-linking of FceRII on IL-1-stimulated YT cells as well as the transfectant of FcεRII-cDNA (YTSER) resulted in the up-regulation of IL-2Rα (p55/Tac). A 59 kDa protein phosphorylated at tyrosine residues was co-immunoprecipitated with FceRII from YTSER lysate using H107 anti-FcεRII mAb.
YTSER not only expressed FceRII on their surface but also secreted soluble form of FcεRII (sFcεRII/sCD23; IgE binding factor). Affinity purification revealed that sFcεRII released from YTSER is heterogeneous and consisted of several proteins differing in molecular weight.
Both EBV
+ B cells and HTLV-1+ T cells are high producers of ATL derived factor (ADF)/ thioredoxin (TRX) and express FcεRII and IL-2Rα respectively. To clarify the mechanism of FcεRII and IL-2Ra induction by ADF/TRX, we examined the effect of ADF/TRX on the bindability of nuclear factor κB (NF-κB), which is known to regulate IL-2Rα gene expression. In the gel shift assay, ADF/TRX was shown to enhance the bindability of NF-κB to its responsive element. |
| doi_str_mv | 10.1016/S0171-2985(11)80641-8 |
| format | Article |
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YTSER not only expressed FceRII on their surface but also secreted soluble form of FcεRII (sFcεRII/sCD23; IgE binding factor). Affinity purification revealed that sFcεRII released from YTSER is heterogeneous and consisted of several proteins differing in molecular weight.
Both EBV
+ B cells and HTLV-1+ T cells are high producers of ATL derived factor (ADF)/ thioredoxin (TRX) and express FcεRII and IL-2Rα respectively. To clarify the mechanism of FcεRII and IL-2Ra induction by ADF/TRX, we examined the effect of ADF/TRX on the bindability of nuclear factor κB (NF-κB), which is known to regulate IL-2Rα gene expression. In the gel shift assay, ADF/TRX was shown to enhance the bindability of NF-κB to its responsive element.</description><identifier>ISSN: 0171-2985</identifier><identifier>EISSN: 1878-3279</identifier><identifier>DOI: 10.1016/S0171-2985(11)80641-8</identifier><identifier>PMID: 1452201</identifier><identifier>CODEN: IMMND4</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Base Sequence ; Biological and medical sciences ; Cell Line ; Cell receptors ; Cell structures and functions ; Chromatography, Ion Exchange ; Cytokines ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunoglobulin E - biosynthesis ; Killer Cells, Natural - metabolism ; Killer Cells, Natural - physiology ; Miscellaneous ; Molecular and cellular biology ; Molecular Sequence Data ; Neoplasm Proteins - immunology ; Oxidation-Reduction - drug effects ; Phosphorylation ; Proto-Oncogene Proteins - immunology ; Proto-Oncogene Proteins c-fyn ; Receptors, IgE - biosynthesis ; Receptors, IgE - physiology ; Thioredoxins - immunology ; Transfection ; Tyrosine - metabolism</subject><ispartof>Immunobiology (1979), 1992-08, Vol.185 (2), p.193-206</ispartof><rights>1992 Gustav Fischer Verlag · Stuttgart · New York</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-470d75ba146c893d971316ff2a861705f9448ca881a82ad853a6ad320d20bb23</citedby><cites>FETCH-LOGICAL-c389t-470d75ba146c893d971316ff2a861705f9448ca881a82ad853a6ad320d20bb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0171298511806418$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4430663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1452201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sorachi, Ken-Ichi</creatorcontrib><creatorcontrib>Sugie, Katsuji</creatorcontrib><creatorcontrib>Maekawa, Noriko</creatorcontrib><creatorcontrib>Takami, Masaaki</creatorcontrib><creatorcontrib>Kawabe, Takumi</creatorcontrib><creatorcontrib>Kumagai, Shunichi</creatorcontrib><creatorcontrib>Imura, Hiroo</creatorcontrib><creatorcontrib>Yodoi, Junji</creatorcontrib><title>Induction and Function of FcεRII on YT Cells; Possible Role of ADF/Thioredoxin in FcεRII Expression</title><title>Immunobiology (1979)</title><addtitle>Immunobiology</addtitle><description>The regulation of low-affinity Fc receptor for lgE (FcγRII) and the characteristics of both membrane and soluble forms of FcγRII were studied using YT cell line. We found that YT cells, a human NK like cell line, expressed FcγRII after IL-1 stimulation. Cross-linking of FceRII on IL-1-stimulated YT cells as well as the transfectant of FcεRII-cDNA (YTSER) resulted in the up-regulation of IL-2Rα (p55/Tac). A 59 kDa protein phosphorylated at tyrosine residues was co-immunoprecipitated with FceRII from YTSER lysate using H107 anti-FcεRII mAb.
YTSER not only expressed FceRII on their surface but also secreted soluble form of FcεRII (sFcεRII/sCD23; IgE binding factor). Affinity purification revealed that sFcεRII released from YTSER is heterogeneous and consisted of several proteins differing in molecular weight.
Both EBV
+ B cells and HTLV-1+ T cells are high producers of ATL derived factor (ADF)/ thioredoxin (TRX) and express FcεRII and IL-2Rα respectively. To clarify the mechanism of FcεRII and IL-2Ra induction by ADF/TRX, we examined the effect of ADF/TRX on the bindability of nuclear factor κB (NF-κB), which is known to regulate IL-2Rα gene expression. In the gel shift assay, ADF/TRX was shown to enhance the bindability of NF-κB to its responsive element.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Chromatography, Ion Exchange</subject><subject>Cytokines</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Killer Cells, Natural - physiology</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Proteins - immunology</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Phosphorylation</subject><subject>Proto-Oncogene Proteins - immunology</subject><subject>Proto-Oncogene Proteins c-fyn</subject><subject>Receptors, IgE - biosynthesis</subject><subject>Receptors, IgE - physiology</subject><subject>Thioredoxins - immunology</subject><subject>Transfection</subject><subject>Tyrosine - metabolism</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN1O2zAUgK1pqBS2R6iUCzSNi4CPncSOdjGhQqESElPXm11Zju0Io9Tu7GZiD8Zr8Ey4pJRLJMvW0fnOjz-EJoDPAEN1_hsDg5zUvPwOcMpxVUDOP6ExcMZzSlj9GY33yCE6ivEBY6gJ4yM0gqIkBMMYmbnTvdpY7zLpdDbr3RD4Npup56fFfJ6l6M8ym5quiz-yXz5G23QmW_h0Jericna-vLc-GO0frcvSeSu8elwHk3DvvqCDVnbRfN29x2g5u1pOb_Lbu-v59OI2V5TXm7xgWLOykVBUitdU1wwoVG1LJK-A4bKti4IryTlITqTmJZWV1JRgTXDTEHqMvg1t18H_7U3ciJWNKi0unfF9FIzSsmSYJrAcQBXSf4JpxTrYlQz_BWCxtSte7YqtOgEgXu0KnuomuwF9szL6vWrQmfInu7yMSnZtkE7ZuMeKguKq2o7_OWAmufhnTRBRWeOU0TYYtRHa2w8WeQFiQpVp</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Sorachi, Ken-Ichi</creator><creator>Sugie, Katsuji</creator><creator>Maekawa, Noriko</creator><creator>Takami, Masaaki</creator><creator>Kawabe, Takumi</creator><creator>Kumagai, Shunichi</creator><creator>Imura, Hiroo</creator><creator>Yodoi, Junji</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>Induction and Function of FcεRII on YT Cells; Possible Role of ADF/Thioredoxin in FcεRII Expression</title><author>Sorachi, Ken-Ichi ; Sugie, Katsuji ; Maekawa, Noriko ; Takami, Masaaki ; Kawabe, Takumi ; Kumagai, Shunichi ; Imura, Hiroo ; Yodoi, Junji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-470d75ba146c893d971316ff2a861705f9448ca881a82ad853a6ad320d20bb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Chromatography, Ion Exchange</topic><topic>Cytokines</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunoglobulin E - biosynthesis</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Killer Cells, Natural - physiology</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Proteins - immunology</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Phosphorylation</topic><topic>Proto-Oncogene Proteins - immunology</topic><topic>Proto-Oncogene Proteins c-fyn</topic><topic>Receptors, IgE - biosynthesis</topic><topic>Receptors, IgE - physiology</topic><topic>Thioredoxins - immunology</topic><topic>Transfection</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sorachi, Ken-Ichi</creatorcontrib><creatorcontrib>Sugie, Katsuji</creatorcontrib><creatorcontrib>Maekawa, Noriko</creatorcontrib><creatorcontrib>Takami, Masaaki</creatorcontrib><creatorcontrib>Kawabe, Takumi</creatorcontrib><creatorcontrib>Kumagai, Shunichi</creatorcontrib><creatorcontrib>Imura, Hiroo</creatorcontrib><creatorcontrib>Yodoi, Junji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunobiology (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sorachi, Ken-Ichi</au><au>Sugie, Katsuji</au><au>Maekawa, Noriko</au><au>Takami, Masaaki</au><au>Kawabe, Takumi</au><au>Kumagai, Shunichi</au><au>Imura, Hiroo</au><au>Yodoi, Junji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction and Function of FcεRII on YT Cells; Possible Role of ADF/Thioredoxin in FcεRII Expression</atitle><jtitle>Immunobiology (1979)</jtitle><addtitle>Immunobiology</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>185</volume><issue>2</issue><spage>193</spage><epage>206</epage><pages>193-206</pages><issn>0171-2985</issn><eissn>1878-3279</eissn><coden>IMMND4</coden><abstract>The regulation of low-affinity Fc receptor for lgE (FcγRII) and the characteristics of both membrane and soluble forms of FcγRII were studied using YT cell line. We found that YT cells, a human NK like cell line, expressed FcγRII after IL-1 stimulation. Cross-linking of FceRII on IL-1-stimulated YT cells as well as the transfectant of FcεRII-cDNA (YTSER) resulted in the up-regulation of IL-2Rα (p55/Tac). A 59 kDa protein phosphorylated at tyrosine residues was co-immunoprecipitated with FceRII from YTSER lysate using H107 anti-FcεRII mAb.
YTSER not only expressed FceRII on their surface but also secreted soluble form of FcεRII (sFcεRII/sCD23; IgE binding factor). Affinity purification revealed that sFcεRII released from YTSER is heterogeneous and consisted of several proteins differing in molecular weight.
Both EBV
+ B cells and HTLV-1+ T cells are high producers of ATL derived factor (ADF)/ thioredoxin (TRX) and express FcεRII and IL-2Rα respectively. To clarify the mechanism of FcεRII and IL-2Ra induction by ADF/TRX, we examined the effect of ADF/TRX on the bindability of nuclear factor κB (NF-κB), which is known to regulate IL-2Rα gene expression. In the gel shift assay, ADF/TRX was shown to enhance the bindability of NF-κB to its responsive element.</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>1452201</pmid><doi>10.1016/S0171-2985(11)80641-8</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Immunobiology (1979), 1992-08, Vol.185 (2), p.193-206 |
| issn | 0171-2985 1878-3279 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Base Sequence Biological and medical sciences Cell Line Cell receptors Cell structures and functions Chromatography, Ion Exchange Cytokines Fundamental and applied biological sciences. Psychology Humans Immunoglobulin E - biosynthesis Killer Cells, Natural - metabolism Killer Cells, Natural - physiology Miscellaneous Molecular and cellular biology Molecular Sequence Data Neoplasm Proteins - immunology Oxidation-Reduction - drug effects Phosphorylation Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins c-fyn Receptors, IgE - biosynthesis Receptors, IgE - physiology Thioredoxins - immunology Transfection Tyrosine - metabolism |
| title | Induction and Function of FcεRII on YT Cells; Possible Role of ADF/Thioredoxin in FcεRII Expression |
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