Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review
Purpose Squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after treatment with radiotherapy (RT). This systematic review addressed the question “Which interventions aimed at optimizing nutrition are of benefit to HNSCC patients receiving RT?” Met...
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| Veröffentlicht in: | Supportive care in cancer 2010-06, Vol.18 (6), p.667-677 |
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| creator | Garg, Shashank Yoo, John Winquist, Eric |
| description | Purpose
Squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after treatment with radiotherapy (RT). This systematic review addressed the question “Which interventions aimed at optimizing nutrition are of benefit to HNSCC patients receiving RT?”
Methods
Randomized controlled trials (RCTs) studying interventions directed at nutritional support of adult patients with HNSCC receiving RT with or without chemotherapy were eligible. RCTs studying prophylaxis of acute mucositis, perioperative nutrition, or palliative and non-HNSCC populations were excluded. A comprehensive literature search was done and meta-analyses planned.
Results
Ten unique RCTs were identified (
n
= 585). All randomized less than 50 patients per trial arm. Five trials studied dietary counseling and/or nutritional supplements, four studied drug interventions, and one studied prophylactic enteral tube feeding. Nutritional status appeared to be maintained or improved with dietary counseling, megestrol acetate, and prophylactic enteral tube feeding.
Conclusions
Data from RCTs supporting the use of interventions to optimize nutrition in HNSCC patients receiving RT are limited in both quantity and quality. Potentially effective interventions have not been tested comparatively or in combination, and few patients receiving chemoradiotherapy were studied. Further research in this area is a priority. |
| doi_str_mv | 10.1007/s00520-009-0686-3 |
| format | Article |
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Squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after treatment with radiotherapy (RT). This systematic review addressed the question “Which interventions aimed at optimizing nutrition are of benefit to HNSCC patients receiving RT?”
Methods
Randomized controlled trials (RCTs) studying interventions directed at nutritional support of adult patients with HNSCC receiving RT with or without chemotherapy were eligible. RCTs studying prophylaxis of acute mucositis, perioperative nutrition, or palliative and non-HNSCC populations were excluded. A comprehensive literature search was done and meta-analyses planned.
Results
Ten unique RCTs were identified (
n
= 585). All randomized less than 50 patients per trial arm. Five trials studied dietary counseling and/or nutritional supplements, four studied drug interventions, and one studied prophylactic enteral tube feeding. Nutritional status appeared to be maintained or improved with dietary counseling, megestrol acetate, and prophylactic enteral tube feeding.
Conclusions
Data from RCTs supporting the use of interventions to optimize nutrition in HNSCC patients receiving RT are limited in both quantity and quality. Potentially effective interventions have not been tested comparatively or in combination, and few patients receiving chemoradiotherapy were studied. Further research in this area is a priority.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-009-0686-3</identifier><identifier>PMID: 19582484</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Analysis ; Appetite Stimulants - therapeutic use ; Cancer ; Cancer patients ; Carcinoma, Squamous Cell - radiotherapy ; Chemotherapy ; Diet therapy ; Dietary Supplements ; Enteral Nutrition ; Head & neck cancer ; Head and Neck Neoplasms - radiotherapy ; Humans ; Medicine ; Medicine & Public Health ; Megestrol acetate ; Nursing ; Nursing Research ; Nutrition ; Nutritional Support - methods ; Oncology ; Original Article ; Pain Medicine ; Palliative Care ; Radiation therapy ; Radiotherapy ; Rehabilitation Medicine ; Squamous cell carcinoma ; Systematic review ; Weight loss</subject><ispartof>Supportive care in cancer, 2010-06, Vol.18 (6), p.667-677</ispartof><rights>Springer-Verlag 2009</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-6126017d1200aa583747793cf3460bf3af1ad3c84c62daa4aa7ba0c6edced9893</citedby><cites>FETCH-LOGICAL-c503t-6126017d1200aa583747793cf3460bf3af1ad3c84c62daa4aa7ba0c6edced9893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-009-0686-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-009-0686-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19582484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garg, Shashank</creatorcontrib><creatorcontrib>Yoo, John</creatorcontrib><creatorcontrib>Winquist, Eric</creatorcontrib><title>Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after treatment with radiotherapy (RT). This systematic review addressed the question “Which interventions aimed at optimizing nutrition are of benefit to HNSCC patients receiving RT?”
Methods
Randomized controlled trials (RCTs) studying interventions directed at nutritional support of adult patients with HNSCC receiving RT with or without chemotherapy were eligible. RCTs studying prophylaxis of acute mucositis, perioperative nutrition, or palliative and non-HNSCC populations were excluded. A comprehensive literature search was done and meta-analyses planned.
Results
Ten unique RCTs were identified (
n
= 585). All randomized less than 50 patients per trial arm. Five trials studied dietary counseling and/or nutritional supplements, four studied drug interventions, and one studied prophylactic enteral tube feeding. Nutritional status appeared to be maintained or improved with dietary counseling, megestrol acetate, and prophylactic enteral tube feeding.
Conclusions
Data from RCTs supporting the use of interventions to optimize nutrition in HNSCC patients receiving RT are limited in both quantity and quality. Potentially effective interventions have not been tested comparatively or in combination, and few patients receiving chemoradiotherapy were studied. Further research in this area is a priority.</description><subject>Analysis</subject><subject>Appetite Stimulants - therapeutic use</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Chemotherapy</subject><subject>Diet therapy</subject><subject>Dietary Supplements</subject><subject>Enteral Nutrition</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Megestrol acetate</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Nutrition</subject><subject>Nutritional Support - methods</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Palliative Care</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Rehabilitation Medicine</subject><subject>Squamous cell carcinoma</subject><subject>Systematic review</subject><subject>Weight loss</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtv1DAUhSMEokPhB7BBFixYpdjxK2ZXVbykCjawtu7YN1OXjBNsp9X8ezzKSBUI5IUl-ztH597TNC8ZvWCU6neZUtnRllLTUtWrlj9qNkxw3mrOzeNmQ41greBSnjXPcr6llGktu6fNGTOy70QvNg18XUoKJUwRRpKXeZ5SIcOUyA2CJxA9ieh-EgfRYSIzlICxZJLQYbgLcUcS-DCVG0wwH94TIPmQC-4r5yp0F_D-efNkgDHji9N93vz4-OH71ef2-tunL1eX162TlJdWsU7VfJ51lALInmuhteFu4ELR7cBhYOC564VTnQcQAHoL1Cn0Dr3pDT9v3q6-c5p-LZiL3YfscBwh4rRkW3cipdKdrOTrv8jbaUl1Adn2ygipqOEVerNCOxjRhjhMJYE7WtpLLrVRWvC-Uhf_oOrxuA9uijiE-v6HgK0Cl6acEw52TmEP6WAZtcdS7VqqraXaY6n2GOXVKe-y3aN_UJxarEC3Arl-xR2mh4H-7_obgjer3w</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Garg, Shashank</creator><creator>Yoo, John</creator><creator>Winquist, Eric</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review</title><author>Garg, Shashank ; Yoo, John ; Winquist, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-6126017d1200aa583747793cf3460bf3af1ad3c84c62daa4aa7ba0c6edced9893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analysis</topic><topic>Appetite Stimulants - therapeutic use</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Chemotherapy</topic><topic>Diet therapy</topic><topic>Dietary Supplements</topic><topic>Enteral Nutrition</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Megestrol acetate</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Nutrition</topic><topic>Nutritional Support - methods</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Palliative Care</topic><topic>Radiation therapy</topic><topic>Radiotherapy</topic><topic>Rehabilitation Medicine</topic><topic>Squamous cell carcinoma</topic><topic>Systematic review</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garg, Shashank</creatorcontrib><creatorcontrib>Yoo, John</creatorcontrib><creatorcontrib>Winquist, Eric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garg, Shashank</au><au>Yoo, John</au><au>Winquist, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>18</volume><issue>6</issue><spage>667</spage><epage>677</epage><pages>667-677</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Squamous cell carcinoma of the head and neck (HNSCC) is associated with weight loss before, during, and after treatment with radiotherapy (RT). This systematic review addressed the question “Which interventions aimed at optimizing nutrition are of benefit to HNSCC patients receiving RT?”
Methods
Randomized controlled trials (RCTs) studying interventions directed at nutritional support of adult patients with HNSCC receiving RT with or without chemotherapy were eligible. RCTs studying prophylaxis of acute mucositis, perioperative nutrition, or palliative and non-HNSCC populations were excluded. A comprehensive literature search was done and meta-analyses planned.
Results
Ten unique RCTs were identified (
n
= 585). All randomized less than 50 patients per trial arm. Five trials studied dietary counseling and/or nutritional supplements, four studied drug interventions, and one studied prophylactic enteral tube feeding. Nutritional status appeared to be maintained or improved with dietary counseling, megestrol acetate, and prophylactic enteral tube feeding.
Conclusions
Data from RCTs supporting the use of interventions to optimize nutrition in HNSCC patients receiving RT are limited in both quantity and quality. Potentially effective interventions have not been tested comparatively or in combination, and few patients receiving chemoradiotherapy were studied. Further research in this area is a priority.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19582484</pmid><doi>10.1007/s00520-009-0686-3</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2010-06, Vol.18 (6), p.667-677 |
| issn | 0941-4355 1433-7339 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Analysis Appetite Stimulants - therapeutic use Cancer Cancer patients Carcinoma, Squamous Cell - radiotherapy Chemotherapy Diet therapy Dietary Supplements Enteral Nutrition Head & neck cancer Head and Neck Neoplasms - radiotherapy Humans Medicine Medicine & Public Health Megestrol acetate Nursing Nursing Research Nutrition Nutritional Support - methods Oncology Original Article Pain Medicine Palliative Care Radiation therapy Radiotherapy Rehabilitation Medicine Squamous cell carcinoma Systematic review Weight loss |
| title | Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review |
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