Endocrine disruptors targeting ERbeta function
Endocrine disruptive chemicals (EDCs) circulating in the environment constitute a risk to ecosystems, wildlife and human health. Oestrogen receptor (ER) alpha and beta are targeted by various kinds of EDCs but the molecular mechanisms and long-term consequences of exposure are largely unknown. Some...
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| Veröffentlicht in: | International journal of andrology 2010-04, Vol.33 (2), p.288-297 |
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| container_title | International journal of andrology |
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| creator | Swedenborg, E Pongratz, I Gustafsson, J-A |
| description | Endocrine disruptive chemicals (EDCs) circulating in the environment constitute a risk to ecosystems, wildlife and human health. Oestrogen receptor (ER) alpha and beta are targeted by various kinds of EDCs but the molecular mechanisms and long-term consequences of exposure are largely unknown. Some biological effects of EDCs are mediated by the aryl hydrocarbon receptor (AhR), which is a key player in the cellular defence against xenobiotic substances. Adding complexity to the picture, there is also accumulating evidence that AhR-ER pathways have an intricate interplay at multiple levels. In this review, we discuss some EDCs that affect the oestrogen pathway by targeting ERbeta. Furthermore, we describe some effects of AhR activities on the oestrogen system. Mechanisms as well as potential adverse effects on human health are discussed. |
| doi_str_mv | 10.1111/j.1365-2605.2009.01025.x |
| format | Article |
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Oestrogen receptor (ER) alpha and beta are targeted by various kinds of EDCs but the molecular mechanisms and long-term consequences of exposure are largely unknown. Some biological effects of EDCs are mediated by the aryl hydrocarbon receptor (AhR), which is a key player in the cellular defence against xenobiotic substances. Adding complexity to the picture, there is also accumulating evidence that AhR-ER pathways have an intricate interplay at multiple levels. In this review, we discuss some EDCs that affect the oestrogen pathway by targeting ERbeta. Furthermore, we describe some effects of AhR activities on the oestrogen system. 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| ispartof | International journal of andrology, 2010-04, Vol.33 (2), p.288-297 |
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| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Aryl Hydrocarbon Receptor Nuclear Translocator - physiology Benzhydryl Compounds Endocrine Disruptors - toxicity Endocrine System - drug effects Environmental Exposure Environmental Pollutants - toxicity Estrogen Receptor beta - drug effects Estrogen Receptor beta - physiology Estrogen Receptor Modulators - pharmacology Female Flame Retardants - toxicity Halogenated Diphenyl Ethers - toxicity Humans Methoxychlor - toxicity Phenols - toxicity Polychlorinated Biphenyls - toxicity Polychlorinated Dibenzodioxins - analogs & derivatives Polychlorinated Dibenzodioxins - pharmacology Polychlorinated Dibenzodioxins - toxicity Receptors, Aryl Hydrocarbon - physiology Signal Transduction - drug effects |
| title | Endocrine disruptors targeting ERbeta function |
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