Detection of Food-Derived Damaged Nucleosides with Possible Adverse Effects on Human Health Using a Global Adductomics Approach

A range of damaged nucleosides, also found in digested dietary DNA, appear to be taken up by cells and incorporated into the cells' own DNA. Most incorporated damaged nucleosides will be repaired by cellular DNA repair systems. However, a small fraction of these will escape repair and thus ulti...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2010-05, Vol.58 (10), p.6370-6375
Hauptverfasser:	Spilsberg, Bjørn, Rundberget, Thomas, Johannessen, Lene E, Kristoffersen, Anja B, Holst-Jensen, Arne, Berdal, Knut G
Format:	Artikel
Sprache:	eng
Schlagworte:	adductomics Agaricus - chemistry Animals Biological and medical sciences brewers yeast Chromatography, Liquid damaged DNA detection DNA - isolation & purification DNA adducts DNA Adducts - analysis DNA Damage DNA repair DNA, Fungal - analysis Food Analysis Food Chemistry/Biochemistry Food industries food safety foods Fundamental and applied biological sciences. Psychology General aspects human health Humans liquid chromatography mass spectrometry Methods of analysis, processing and quality control, regulation, standards mushrooms mutation nucleosides Nucleosides - adverse effects Nucleosides - analysis Saccharomyces cerevisiae - chemistry single cell protein Tandem Mass Spectrometry uptake mechanisms
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