Coarse Grained Simulations of Local Anesthetics Encapsulated into a Liposome

We investigated the encapsulation of prilocaine (PLC), an aminoamide local anesthetic widely used in dentistry, into a small unilamellar liposome. We extended a recently developed coarse grained model to access the problem relevant time and length scales. Molecular dynamics (MD) simulations for diff...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The journal of physical chemistry. B 2010-05, Vol.114 (20), p.7009-7015
Hauptverfasser:	Pickholz, Mónica, Giupponi, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - administration & dosage Anesthetics, Local - chemistry B: Biophysical Chemistry Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Liposomes - chemistry Molecular Dynamics Simulation Phosphatidylcholines - chemistry Prilocaine - administration & dosage Prilocaine - chemistry Static Electricity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!