Tumor Lysis Syndrome and Acute Kidney Injury: Evaluation, Prevention, and Management
Tumor lysis syndrome (TLS) describes a constellation of biochemical and clinical abnormalities resulting from rapid and massive tumor cell death. TLS is frequently associated with hyperuricemia, hyperkalemia, hyperphosphatemia, and secondary hypocalcemia that may lead to serious clinical complicatio...
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| Veröffentlicht in: | American journal of kidney diseases 2010-05, Vol.55 (5), p.S1-S13 |
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| container_title | American journal of kidney diseases |
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| creator | Abu-Alfa, Ali K., MD Younes, Anas, MD |
| description | Tumor lysis syndrome (TLS) describes a constellation of biochemical and clinical abnormalities resulting from rapid and massive tumor cell death. TLS is frequently associated with hyperuricemia, hyperkalemia, hyperphosphatemia, and secondary hypocalcemia that may lead to serious clinical complications, including acute kidney injury and cardiac arrest. Identification of tumor- and patient-specific risk factors for TLS and early recognition of laboratory and clinical TLS based on established criteria are essential for preventing TLS and forestalling acute kidney injury. Early collaboration between oncologists and nephrologists will help improve assessment of patients' kidney function and risk factors, paving the way for timely and efficacious interventions. |
| doi_str_mv | 10.1053/j.ajkd.2009.10.056 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0272-6386 |
| ispartof | American journal of kidney diseases, 2010-05, Vol.55 (5), p.S1-S13 |
| issn | 0272-6386 1523-6838 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Acute Disease acute kidney injury hematologic malignancy Humans hyperuricemia Incidence Kidney Diseases - epidemiology Kidney Diseases - etiology Kidney Diseases - prevention & control Kidney Diseases - therapy Nephrology prevention Risk Factors Tumor lysis syndrome Tumor Lysis Syndrome - complications Tumor Lysis Syndrome - etiology Tumor Lysis Syndrome - prevention & control Tumor Lysis Syndrome - therapy |
| title | Tumor Lysis Syndrome and Acute Kidney Injury: Evaluation, Prevention, and Management |
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