Id1/Id3 Knockdown Inhibits Metastatic Potential of Pancreatic Cancer

Background The Id (inhibitor of DNA binding/differentiation) proteins belong to the helix-loop-helix transcriptional regulatory factors, and play important roles in tumor development. Previously, we and others have shown that targeting Id in tumor cells could have important clinical implications. In...

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Veröffentlicht in:	The Journal of surgical research 2010-06, Vol.161 (1), p.76-82
Hauptverfasser:	Shuno, Yasutaka, M.D, Tsuno, Nelson H., M.D., Ph.D, Okaji, Yurai, M.D., Ph.D, Tsuchiya, Takeshi, M.D., Ph.D, Sakurai, Daisuke, Ph.D, Nishikawa, Takeshi, M.D, Yoshikawa, Naoyuki, M.A, Sasaki, Kazuhito, M.D, Hongo, Kumiko, M.D, Tsurita, Giichiro, M.D., Ph.D, Sunami, Eiji, M.D., Ph.D, Kitayama, Joji, M.D., Ph.D, Tokunaga, Katsushi, Ph.D, Takahashi, Koki, M.D., Ph.D, Nagawa, Hirokazu, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma - metabolism Carcinoma - therapy cell adhesion Cell Line, Tumor cell migration Cell Movement Cell Proliferation Down-Regulation Extracellular Matrix Proteins - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Gene Knockdown Techniques General aspects Humans Id gene Inhibitor of Differentiation Protein 1 - genetics Inhibitor of Differentiation Protein 1 - metabolism Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - metabolism integrin Integrins - metabolism laminin Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences metastasis Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - therapy RNA Interference Surgery Tumors
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