Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: Formulation optimization, ex vivo and in vivo characterization

The purpose of the present study was to develop and optimize the microemulsion based transdermal therapeutic system for lacidipine (LCDP), a poorly water soluble and low bioavailable drug. The pseudo-ternary phase diagrams were developed for various microemulsion formulations composed of isopropyl m...

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Veröffentlicht in:	International journal of pharmaceutics 2010-03, Vol.388 (1), p.231-241
Hauptverfasser:	Gannu, Ramesh, Palem, Chinna Reddy, Yamsani, Vamshi Vishnu, Yamsani, Shravan Kumar, Yamsani, Madhusudan Rao
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Bioavailability Biological and medical sciences Biological Availability Box–Behnken Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacokinetics Chemistry, Pharmaceutical - methods Data Interpretation, Statistical Dihydropyridines - administration & dosage Dihydropyridines - chemistry Dihydropyridines - pharmacokinetics Emulsions EVIV correlation Gels General pharmacology Glycerides Lacidipine Medical sciences Microemulgel Microemulsion Myristates - chemistry Optimization Organic Chemicals - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Phase Transition Polysorbates - chemistry Rabbits Rats Rats, Wistar Skin Absorption Solubility Surface-Active Agents - chemistry
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