Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm

Summary Objective: To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. Methods: Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide’s serum concentration dete...

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Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2010-02, Vol.35 (1), p.105-112
Hauptverfasser:	Ruzilawati, A. B., Mohd Suhaimi, A. W., Gan, S. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Algorithms Biological and medical sciences Body Mass Index Carbamates - blood Carbamates - pharmacokinetics Female Half-Life Humans Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics it2b Male Medical sciences Metabolic Clearance Rate Middle Aged Models, Biological npag Pharmacology. Drug treatments Piperidines - blood Piperidines - pharmacokinetics population pharmacokinetic modelling repaglinide Young Adult
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