Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency

Background: Factor VIII (FVIII) and its activated form (FVIIIa) are subject to proteolysis that dampens their cofactor function. Among the proteases that attack FVIII (activated factor X (FXa), activated protein C (APC) and plasmin), only APC cleaves within the FVIII A2 domain at R562 to fully aboli...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2010-02, Vol.8 (2), p.286-293
Hauptverfasser:	PLANTIER, J. L., ROLLI, V., DUCASSE, C., DARGAUD, Y., ENJOLRAS, N., BOUKERCHE, H., NÉGRIER, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine CHO Cells coagulation Cricetinae Cricetulus Factor IXa - metabolism factor VIII Factor VIII - chemistry Factor VIII - genetics Factor VIII - metabolism factor Xa Factor Xa - metabolism hemostasis Humans Kinetics Mutation Phospholipids - metabolism Protein Processing, Post-Translational Protein Structure, Tertiary proteolysis Recombinant Proteins - metabolism Substrate Specificity Transfection von Willebrand Factor - metabolism
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