Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of 177Lu-EDTMP, a potential bone pain palliation agent

Radionuclide therapy (RNT) is an effective method for bone pain palliation in patients suffering from bone metastasis. Due to the long half-life, easy production and relatively low β− energy, 177Lu [ T 1/2=6.73 days, E βmax=497 keV, E γ=113 keV (6.4%), 208 keV (11%)]-based radiopharmaceuticals offer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nuclear medicine and biology 2010-02, Vol.37 (2), p.215-226
Hauptverfasser:	Máthé, Domokos, Balogh, Lajos, Polyák, András, Király, Réka, Márián, Teréz, Pawlak, Dariusz, Zaknun, John J., Pillai, Maroor R.A., Jánoki, Győző A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal studies Animals Biological and medical sciences Bone and Bones - diagnostic imaging Bone and Bones - pathology Bone and Bones - radiation effects Bone seeking radiopharmaceuticals Contrast media. Radiopharmaceuticals Dogs Drug toxicity and drugs side effects treatment In vivo biodistribution Male Medical sciences Mice Miscellaneous (drug allergy, mutagens, teratogens...) Organometallic Compounds - pharmacokinetics Organometallic Compounds - therapeutic use Organometallic Compounds - toxicity Organophosphorus Compounds - pharmacokinetics Organophosphorus Compounds - therapeutic use Organophosphorus Compounds - toxicity Pain - radiotherapy Pain Management Palliative Care Pharmacology. Drug treatments Rabbits Radionuclide therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Small animal imaging Technology. Biomaterials. Equipments. Material. Instrumentation Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!