Total Synthesis of Chloptosin, a Potent Apoptosis-Inducing Cyclopeptide

A bidirectional total synthesis of chloptosin has been achieved in 16 operations (32 individual reactions) and 3% overall yield from the readily available materials. Palladium-catalyzed tryptophan synthesis, diastereoselective selenocyclization and oxidative deselenation successfully served as key s...

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Veröffentlicht in:	Organic letters 2010-03, Vol.12 (5), p.1124-1127
Hauptverfasser:	Yu, Shun-Ming, Hong, Wen-Xu, Wu, Yuan, Zhong, Chun-Long, Yao, Zhu-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Catalysis Cell Line, Tumor Humans Magnetic Resonance Spectroscopy Mice Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pyridazines - chemical synthesis Pyridazines - chemistry Pyridazines - pharmacology
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