An epidemiological analysis of hepatitis A virus serologic markers during the recent four years in Korea
To establish effective preventive measures for hepatitis A virus (HAV) infection, a nationwide epidemiologic study on seroprevalence of anti-HAV and the disease prevalence is needed. The aim of this study was to analyze the recent sero-epidemiological changes of hepatitis A markers in Korea. The res...
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| Veröffentlicht in: | Taehan Chindan Kŏmsa Ŭihakhoe chi 2009-12, Vol.29 (6), p.563-569 |
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| container_title | Taehan Chindan Kŏmsa Ŭihakhoe chi |
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| creator | Lee, Anna Lim, Hyun-Sun Nam, Chung-Mo Song, Sean-Mi Yoon, Hye-Ryoung Lee, Kyoung-Ryul |
| description | To establish effective preventive measures for hepatitis A virus (HAV) infection, a nationwide epidemiologic study on seroprevalence of anti-HAV and the disease prevalence is needed. The aim of this study was to analyze the recent sero-epidemiological changes of hepatitis A markers in Korea.
The results of 11,068 anti-HAV total and 32,360 anti-HAV IgM tests by electro-chemiluminescence immunoassay (ECLIA) that had been requested in recent four years (2005-2008) to a reference medical laboratory from 1,699 institutions nationwide were retrospectively analyzed according to the distribution of year, sex, and age groups.
The overall positive rate of anti-HAV total was 62.8%. The overall positive rate of anti-HAV IgM was 11.0%, showing a significantly increasing trend by year: 7.7%, 10.9%, 8.9%, and 14.3% in 2005, 2006, 2007, and 2008, respectively (P or = 21 yr. The results of this study could be used effectively as a basic data for establishing effective preventive measures for hepatitis A including vaccination in these susceptible age groups. |
| doi_str_mv | 10.3343/kjlm.2009.29.6.563 |
| format | Article |
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The results of 11,068 anti-HAV total and 32,360 anti-HAV IgM tests by electro-chemiluminescence immunoassay (ECLIA) that had been requested in recent four years (2005-2008) to a reference medical laboratory from 1,699 institutions nationwide were retrospectively analyzed according to the distribution of year, sex, and age groups.
The overall positive rate of anti-HAV total was 62.8%. The overall positive rate of anti-HAV IgM was 11.0%, showing a significantly increasing trend by year: 7.7%, 10.9%, 8.9%, and 14.3% in 2005, 2006, 2007, and 2008, respectively (P<0.0001). The positive rate of anti-HAV IgM was higher in male than in female subjects (11.8% vs 10.0%, P<0.0001), and 81.8% (2,916/3,566) of the anti-HAV IgM positive results were observed in the age groups of 21-40 yr. The annual positive rates of anti-HAV total and anti-HAV IgM showed significantly decreasing and increasing trends, respectively, in the age groups of > or = 21 yr.
In accordance with a decreasing sero-positivity of anti-HAV total, the prevalence of acute hepatitis A virus infection has been considerably increased during the recent four years in the age groups of > or = 21 yr. The results of this study could be used effectively as a basic data for establishing effective preventive measures for hepatitis A including vaccination in these susceptible age groups.</description><identifier>ISSN: 1598-6535</identifier><identifier>DOI: 10.3343/kjlm.2009.29.6.563</identifier><identifier>PMID: 20046089</identifier><language>kor</language><publisher>Korea (South)</publisher><subject>Adult ; Biomarkers - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis A - epidemiology ; Hepatitis A Antibodies - blood ; Hepatitis A virus - immunology ; Humans ; Immunoglobulin M - blood ; Luminescent Measurements ; Male ; Middle Aged ; Republic of Korea - epidemiology ; Retrospective Studies ; Sex Factors ; Time Factors</subject><ispartof>Taehan Chindan Kŏmsa Ŭihakhoe chi, 2009-12, Vol.29 (6), p.563-569</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20046089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Anna</creatorcontrib><creatorcontrib>Lim, Hyun-Sun</creatorcontrib><creatorcontrib>Nam, Chung-Mo</creatorcontrib><creatorcontrib>Song, Sean-Mi</creatorcontrib><creatorcontrib>Yoon, Hye-Ryoung</creatorcontrib><creatorcontrib>Lee, Kyoung-Ryul</creatorcontrib><title>An epidemiological analysis of hepatitis A virus serologic markers during the recent four years in Korea</title><title>Taehan Chindan Kŏmsa Ŭihakhoe chi</title><addtitle>Korean J Lab Med</addtitle><description>To establish effective preventive measures for hepatitis A virus (HAV) infection, a nationwide epidemiologic study on seroprevalence of anti-HAV and the disease prevalence is needed. The aim of this study was to analyze the recent sero-epidemiological changes of hepatitis A markers in Korea.
The results of 11,068 anti-HAV total and 32,360 anti-HAV IgM tests by electro-chemiluminescence immunoassay (ECLIA) that had been requested in recent four years (2005-2008) to a reference medical laboratory from 1,699 institutions nationwide were retrospectively analyzed according to the distribution of year, sex, and age groups.
The overall positive rate of anti-HAV total was 62.8%. The overall positive rate of anti-HAV IgM was 11.0%, showing a significantly increasing trend by year: 7.7%, 10.9%, 8.9%, and 14.3% in 2005, 2006, 2007, and 2008, respectively (P<0.0001). The positive rate of anti-HAV IgM was higher in male than in female subjects (11.8% vs 10.0%, P<0.0001), and 81.8% (2,916/3,566) of the anti-HAV IgM positive results were observed in the age groups of 21-40 yr. The annual positive rates of anti-HAV total and anti-HAV IgM showed significantly decreasing and increasing trends, respectively, in the age groups of > or = 21 yr.
In accordance with a decreasing sero-positivity of anti-HAV total, the prevalence of acute hepatitis A virus infection has been considerably increased during the recent four years in the age groups of > or = 21 yr. The results of this study could be used effectively as a basic data for establishing effective preventive measures for hepatitis A including vaccination in these susceptible age groups.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Hepatitis A - epidemiology</subject><subject>Hepatitis A Antibodies - blood</subject><subject>Hepatitis A virus - immunology</subject><subject>Humans</subject><subject>Immunoglobulin M - blood</subject><subject>Luminescent Measurements</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Republic of Korea - epidemiology</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Time Factors</subject><issn>1598-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtrwzAcxDW0NCHNF-hQtHWyq7eiMYS-aKBLOxtZ_jtWIz8q2YV8-xqSTsdxPw7uELqjJOdc8Mfjd2hzRojJmclVLhW_QksqzSZTkssFWqfkS0IZY5oKcYMWMysU2ZglarYdhsFX0Po-9AfvbMC2s-GUfMJ9jRsY7OjH2Wzxr49TwgnimcStjUeICVdT9N0Bjw3gCA66Edf9FPEJ7Bz6Dr_3Eewtuq5tSLC-6Ap9PT997l6z_cfL2267zwZGyZhxR6AmmjlWWahlZYCIuZNqBlqBLrW0dWUoF5puuLGUaWGNMcKpklKmHF-hh3PvEPufCdJYtD45CMF20E-p0JxLQY02M3l_IaeyhaoYop8XnYr_c_gfmKBnow</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Lee, Anna</creator><creator>Lim, Hyun-Sun</creator><creator>Nam, Chung-Mo</creator><creator>Song, Sean-Mi</creator><creator>Yoon, Hye-Ryoung</creator><creator>Lee, Kyoung-Ryul</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>An epidemiological analysis of hepatitis A virus serologic markers during the recent four years in Korea</title><author>Lee, Anna ; Lim, Hyun-Sun ; Nam, Chung-Mo ; Song, Sean-Mi ; Yoon, Hye-Ryoung ; Lee, Kyoung-Ryul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p210t-3c0ef072c2daef5d9e04ece172e76e7b75afd913471839a1274a9994c6b1126c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Hepatitis A - epidemiology</topic><topic>Hepatitis A Antibodies - blood</topic><topic>Hepatitis A virus - immunology</topic><topic>Humans</topic><topic>Immunoglobulin M - blood</topic><topic>Luminescent Measurements</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Republic of Korea - epidemiology</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Lee, Anna</creatorcontrib><creatorcontrib>Lim, Hyun-Sun</creatorcontrib><creatorcontrib>Nam, Chung-Mo</creatorcontrib><creatorcontrib>Song, Sean-Mi</creatorcontrib><creatorcontrib>Yoon, Hye-Ryoung</creatorcontrib><creatorcontrib>Lee, Kyoung-Ryul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Taehan Chindan Kŏmsa Ŭihakhoe chi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Anna</au><au>Lim, Hyun-Sun</au><au>Nam, Chung-Mo</au><au>Song, Sean-Mi</au><au>Yoon, Hye-Ryoung</au><au>Lee, Kyoung-Ryul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An epidemiological analysis of hepatitis A virus serologic markers during the recent four years in Korea</atitle><jtitle>Taehan Chindan Kŏmsa Ŭihakhoe chi</jtitle><addtitle>Korean J Lab Med</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>29</volume><issue>6</issue><spage>563</spage><epage>569</epage><pages>563-569</pages><issn>1598-6535</issn><abstract>To establish effective preventive measures for hepatitis A virus (HAV) infection, a nationwide epidemiologic study on seroprevalence of anti-HAV and the disease prevalence is needed. The aim of this study was to analyze the recent sero-epidemiological changes of hepatitis A markers in Korea.
The results of 11,068 anti-HAV total and 32,360 anti-HAV IgM tests by electro-chemiluminescence immunoassay (ECLIA) that had been requested in recent four years (2005-2008) to a reference medical laboratory from 1,699 institutions nationwide were retrospectively analyzed according to the distribution of year, sex, and age groups.
The overall positive rate of anti-HAV total was 62.8%. The overall positive rate of anti-HAV IgM was 11.0%, showing a significantly increasing trend by year: 7.7%, 10.9%, 8.9%, and 14.3% in 2005, 2006, 2007, and 2008, respectively (P<0.0001). The positive rate of anti-HAV IgM was higher in male than in female subjects (11.8% vs 10.0%, P<0.0001), and 81.8% (2,916/3,566) of the anti-HAV IgM positive results were observed in the age groups of 21-40 yr. The annual positive rates of anti-HAV total and anti-HAV IgM showed significantly decreasing and increasing trends, respectively, in the age groups of > or = 21 yr.
In accordance with a decreasing sero-positivity of anti-HAV total, the prevalence of acute hepatitis A virus infection has been considerably increased during the recent four years in the age groups of > or = 21 yr. The results of this study could be used effectively as a basic data for establishing effective preventive measures for hepatitis A including vaccination in these susceptible age groups.</abstract><cop>Korea (South)</cop><pmid>20046089</pmid><doi>10.3343/kjlm.2009.29.6.563</doi><tpages>7</tpages></addata></record> |
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| source | KoreaMed Synapse; MEDLINE; KoreaMed Open Access; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biomarkers - blood Enzyme-Linked Immunosorbent Assay Female Hepatitis A - epidemiology Hepatitis A Antibodies - blood Hepatitis A virus - immunology Humans Immunoglobulin M - blood Luminescent Measurements Male Middle Aged Republic of Korea - epidemiology Retrospective Studies Sex Factors Time Factors |
| title | An epidemiological analysis of hepatitis A virus serologic markers during the recent four years in Korea |
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