ZP123 Increases Gap Junctional Conductance and Prevents Reentrant Ventricular Tachycardia During Myocardial Ischemia in Open Chest Dogs

Introduction: The aim of this study was to determine if the stable antiarrhythmic peptide (AAP) analogue ZP123 increases gap junctional intercellular conductance and prevents reentrant ventricular tachycardia (VT) during coronary artery occlusion. Methods and Results: Voltage clamp experiments demon...

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Veröffentlicht in:	Journal of cardiovascular electrophysiology 2003-05, Vol.14 (5), p.510-520
Hauptverfasser:	Xing, Dezhi, Kjølbye, Anne Louise, Nielsen, Morten S., Petersen, Jørgen S., Harlow, Kenneth W., Holstein-Rathlou, Niels-Henrik, Martins, James B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - physiology Cell Membrane - drug effects Cell Membrane - metabolism Disease Models, Animal Dogs Dose-Response Relationship, Drug Electrocardiography Female gap junctions Gap Junctions - drug effects Heart Block - metabolism Heart Block - physiopathology Heart Block - prevention & control Heart Conduction System - drug effects Heart Conduction System - metabolism Heart Conduction System - physiopathology Incidence Infusions, Intravenous Male Models, Cardiovascular myocardial ischemia Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - ultrastructure Oligopeptides - administration & dosage Oligopeptides - pharmacology Oligopeptides - therapeutic use Reproducibility of Results Statistics as Topic Tachycardia, Ventricular - metabolism Tachycardia, Ventricular - physiopathology Tachycardia, Ventricular - prevention & control ventricular tachycardia
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