Industrial scale harvest of proteins from mammalian cell culture by tangential flow filtration

An industrial‐scale methods for harvest of biologically active proteins form mammalian cell culture has been developed using tangential flow filtration. A robust and economical process capable of processing approximately 5000 L conditioned media/h with protein yields in excess of 99% has been achiev...

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Veröffentlicht in:	Biotechnology and bioengineering 1991-08, Vol.38 (4), p.413-422
Hauptverfasser:	van Reis, Robert, Leonard, Lee C., Hsu, Chung C., Builder, Stuart E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects, investigation methods linear scale-up pharmaceutical proteins plasminogen activator Proteins tangential flow filtration
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