Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

Cytosolic viral RNA recognition by the helicases RIG-I and MDA5 is considered the major pathway for IFN-alpha/beta induction in response to RNA viruses. However, other cytoplasmic RNA sensors, including the double-stranded RNA-binding protein kinase R (PKR), have been implicated in IFN-alpha/beta pr...

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Veröffentlicht in:	Cell host & microbe 2010-05, Vol.7 (5), p.354-361
Hauptverfasser:	Schulz, Oliver, Pichlmair, Andreas, Rehwinkel, Jan, Rogers, Neil C, Scheuner, Donalyn, Kato, Hiroki, Takeuchi, Osamu, Akira, Shizuo, Kaufman, Randal J, Reis e Sousa, Caetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals eIF-2 Kinase - genetics eIF-2 Kinase - immunology eIF-2 Kinase - metabolism Encephalomyocarditis virus - immunology Interferon-alpha - biosynthesis Interferon-beta - biosynthesis Mice Mice, Knockout Orthomyxoviridae - immunology RNA, Messenger - metabolism Semliki forest virus - immunology Sendai virus - immunology Theilovirus - immunology
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