An Improved Synthesis of the Selective EP4 Receptor Agonist ONO-4819

An improved synthesis of the highly selective EP4-receptor agonist ONO-4819 has been developed. The previous synthesis suffered from several drawbacks, in which a critical one is the difficulty in the removal of byproducts leading to unsatisfactory quality of the active pharmaceutical ingredient (AP...

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Veröffentlicht in:	Journal of organic chemistry 2009-11, Vol.74 (21), p.8298-8308
Hauptverfasser:	Ohta, Chisa, Kuwabe, Shin-itsu, Shiraishi, Tai, Shinohara, Ikuo, Araki, Hiroshi, Sakuyama, Shigeru, Makihara, Takayuki, Kawanaka, Yasufumi, Ohuchida, Shuichi, Seko, Takuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry Chromatography, High Pressure Liquid Exact sciences and technology Heptanoates - chemical synthesis Heptanoates - pharmacology Magnetic Resonance Spectroscopy Noncondensed benzenic compounds Organic chemistry Preparations and properties Receptors, Prostaglandin E - agonists Receptors, Prostaglandin E, EP4 Subtype Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared
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