Deregulation of cell death (apoptosis): implications for tumor development

Deregulation of cell death (apoptosis): implications for tumor development

The first descriptions of apoptosis were made over 150 years ago, although the implications for tumor development were not appreciated until the 1970s. Natural cell death is a critical part of development of multicellular organisms, and also counter-balances the cell generating effects of mitosis. D...

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Veröffentlicht in:Discovery medicine 2009-08, Vol.8 (41), p.61-63
Hauptverfasser: Pettigrew, Christopher A, Cotter, Thomas G
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis - physiology
Humans
Neoplasms - metabolism
Neoplasms - pathology
Proto-Oncogene Proteins c-bcl-2 - genetics
Proto-Oncogene Proteins c-bcl-2 - metabolism
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container_title Discovery medicine
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creator Pettigrew, Christopher A
Cotter, Thomas G
description The first descriptions of apoptosis were made over 150 years ago, although the implications for tumor development were not appreciated until the 1970s. Natural cell death is a critical part of development of multicellular organisms, and also counter-balances the cell generating effects of mitosis. Disruptions in the highly regulated apoptotic pathway can lead to disease, such as tumors, due to the accumulation of excessive numbers of cells. Restoring normal apoptosis in cancer cells is one of the current challenges of cancer research.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Animals
Apoptosis - physiology
Humans
Neoplasms - metabolism
Neoplasms - pathology
Proto-Oncogene Proteins c-bcl-2 - genetics
Proto-Oncogene Proteins c-bcl-2 - metabolism
title Deregulation of cell death (apoptosis): implications for tumor development
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