On the probability that kidneys are different in autosomal dominant polycystic disease
On the probability that kidneys are different in autosomal dominant polycystic disease. We hypothesized that highly variable cyst fluid sodium concentrations are a characteristic of every kidney in autosomal dominant polycystic kidney disease (ADPKD). We added our data on sodium concentrations in 12...
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| Veröffentlicht in: | Kidney international 1992-11, Vol.42 (5), p.1199-1206 |
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| container_title | Kidney international |
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| creator | Gardner, Kenneth D. Burnside, Janet S. Skipper, Betty J. Swan, Suzanne K. Bennett, William M. Connors, Bret A. Evan, Andrew P. |
| description | On the probability that kidneys are different in autosomal dominant polycystic disease. We hypothesized that highly variable cyst fluid sodium concentrations are a characteristic of every kidney in autosomal dominant polycystic kidney disease (ADPKD). We added our data on sodium concentrations in 124 fluids from ten ADPKD kidneys to data published by others of concentrations in 32 fluids from five kidneys. The values ranged from 3 to 207 mEq/liter; none fell between 59 and 74 mEq/liter. Fluids were designated as low (< 60 mEq/liter; 50 fluids) or high (> 60 mEq/liter; 106 fluids) sodium fluids. Transmission electron microscopy identified differences in the depths of apical tight junctions between cells from cyst walls of 12 of the low and 10 of the high sodium fluids from two kidneys (mean ± SE depths of 2039 ± 74 Å vs. 386 ± 18A respectively; P < 0.0001). When fluids were grouped by kidney of origin, six of the 15 kidneys had only high sodium fluids. The probability that chance had led to the sampling of only high sodium fluids in these organs, given that 32% of all fluids were low sodium fluids, was calculated at < 0.00015. The possibility must be considered that all kidneys are not alike in ADPKD. |
| doi_str_mv | 10.1038/ki.1992.405 |
| format | Article |
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We hypothesized that highly variable cyst fluid sodium concentrations are a characteristic of every kidney in autosomal dominant polycystic kidney disease (ADPKD). We added our data on sodium concentrations in 124 fluids from ten ADPKD kidneys to data published by others of concentrations in 32 fluids from five kidneys. The values ranged from 3 to 207 mEq/liter; none fell between 59 and 74 mEq/liter. Fluids were designated as low (< 60 mEq/liter; 50 fluids) or high (> 60 mEq/liter; 106 fluids) sodium fluids. Transmission electron microscopy identified differences in the depths of apical tight junctions between cells from cyst walls of 12 of the low and 10 of the high sodium fluids from two kidneys (mean ± SE depths of 2039 ± 74 Å vs. 386 ± 18A respectively; P < 0.0001). When fluids were grouped by kidney of origin, six of the 15 kidneys had only high sodium fluids. The probability that chance had led to the sampling of only high sodium fluids in these organs, given that 32% of all fluids were low sodium fluids, was calculated at < 0.00015. The possibility must be considered that all kidneys are not alike in ADPKD.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1992.405</identifier><identifier>PMID: 1453604</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Body Fluids - metabolism ; Creatinine - metabolism ; Female ; Humans ; Intercellular Junctions - metabolism ; Intercellular Junctions - ultrastructure ; Kidney - metabolism ; Kidney - ultrastructure ; Kidneys ; Male ; Medical sciences ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Middle Aged ; Nephrology. Urinary tract diseases ; Osmolar Concentration ; Polycystic Kidney, Autosomal Dominant - metabolism ; Polycystic Kidney, Autosomal Dominant - pathology ; Sodium - metabolism ; Tissue Distribution ; Tumors of the urinary system</subject><ispartof>Kidney international, 1992-11, Vol.42 (5), p.1199-1206</ispartof><rights>1992 International Society of Nephrology</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-67c2082fdd65cebf0713b4be2cf5f16c661e2f9d3399361725643319040671c13</citedby><cites>FETCH-LOGICAL-c420t-67c2082fdd65cebf0713b4be2cf5f16c661e2f9d3399361725643319040671c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4439956$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1453604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gardner, Kenneth D.</creatorcontrib><creatorcontrib>Burnside, Janet S.</creatorcontrib><creatorcontrib>Skipper, Betty J.</creatorcontrib><creatorcontrib>Swan, Suzanne K.</creatorcontrib><creatorcontrib>Bennett, William M.</creatorcontrib><creatorcontrib>Connors, Bret A.</creatorcontrib><creatorcontrib>Evan, Andrew P.</creatorcontrib><title>On the probability that kidneys are different in autosomal dominant polycystic disease</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>On the probability that kidneys are different in autosomal dominant polycystic disease. We hypothesized that highly variable cyst fluid sodium concentrations are a characteristic of every kidney in autosomal dominant polycystic kidney disease (ADPKD). We added our data on sodium concentrations in 124 fluids from ten ADPKD kidneys to data published by others of concentrations in 32 fluids from five kidneys. The values ranged from 3 to 207 mEq/liter; none fell between 59 and 74 mEq/liter. Fluids were designated as low (< 60 mEq/liter; 50 fluids) or high (> 60 mEq/liter; 106 fluids) sodium fluids. Transmission electron microscopy identified differences in the depths of apical tight junctions between cells from cyst walls of 12 of the low and 10 of the high sodium fluids from two kidneys (mean ± SE depths of 2039 ± 74 Å vs. 386 ± 18A respectively; P < 0.0001). When fluids were grouped by kidney of origin, six of the 15 kidneys had only high sodium fluids. The probability that chance had led to the sampling of only high sodium fluids in these organs, given that 32% of all fluids were low sodium fluids, was calculated at < 0.00015. The possibility must be considered that all kidneys are not alike in ADPKD.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Fluids - metabolism</subject><subject>Creatinine - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Intercellular Junctions - metabolism</subject><subject>Intercellular Junctions - ultrastructure</subject><subject>Kidney - metabolism</subject><subject>Kidney - ultrastructure</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Electron, Scanning</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Osmolar Concentration</subject><subject>Polycystic Kidney, Autosomal Dominant - metabolism</subject><subject>Polycystic Kidney, Autosomal Dominant - pathology</subject><subject>Sodium - metabolism</subject><subject>Tissue Distribution</subject><subject>Tumors of the urinary system</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1r3DAQxUVoSTZpTj2X-BByCd7q2_axhHxBIJe2VyFLI6quLW8lOeD_vlq8pJcyh2Hm_Zh5PIQ-E7wlmLVfd35Luo5uORYnaEMEZTVphPiANhi3oqaCtWfoPKXfuMwdw6folHDBJOYb9PM1VPkXVPs49br3g89LmXWudt4GWFKlI1TWOwcRQq58qPScpzSNeqjsNPqgy3Y_DYtZUvamoAl0gk_oo9NDgstjv0A_Hu6_3z3VL6-Pz3ffXmrDKc61bAzFLXXWSmGgd7ghrOc9UOOEI9JISYC6zjLWdUyShgrJGSMd5lg2xBB2gW7Wu8X_nxlSVqNPBoZBB5jmpBrGRKm2gLcraOKUUgSn9tGPOi6KYHVIUe28OqSoSoqF_nI8O_cj2H_sGlvRr4-6TkYPLupgfHrHOC9-hSzY1YoFnecI7_rOHz6tj8RKQAnpzUNUyXgIBqyPYLKyk_-vwb8tH5Yh</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>Gardner, Kenneth D.</creator><creator>Burnside, Janet S.</creator><creator>Skipper, Betty J.</creator><creator>Swan, Suzanne K.</creator><creator>Bennett, William M.</creator><creator>Connors, Bret A.</creator><creator>Evan, Andrew P.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921101</creationdate><title>On the probability that kidneys are different in autosomal dominant polycystic disease</title><author>Gardner, Kenneth D. ; Burnside, Janet S. ; Skipper, Betty J. ; Swan, Suzanne K. ; Bennett, William M. ; Connors, Bret A. ; Evan, Andrew P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-67c2082fdd65cebf0713b4be2cf5f16c661e2f9d3399361725643319040671c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Fluids - metabolism</topic><topic>Creatinine - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Intercellular Junctions - metabolism</topic><topic>Intercellular Junctions - ultrastructure</topic><topic>Kidney - metabolism</topic><topic>Kidney - ultrastructure</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Electron, Scanning</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Osmolar Concentration</topic><topic>Polycystic Kidney, Autosomal Dominant - metabolism</topic><topic>Polycystic Kidney, Autosomal Dominant - pathology</topic><topic>Sodium - metabolism</topic><topic>Tissue Distribution</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gardner, Kenneth D.</creatorcontrib><creatorcontrib>Burnside, Janet S.</creatorcontrib><creatorcontrib>Skipper, Betty J.</creatorcontrib><creatorcontrib>Swan, Suzanne K.</creatorcontrib><creatorcontrib>Bennett, William M.</creatorcontrib><creatorcontrib>Connors, Bret A.</creatorcontrib><creatorcontrib>Evan, Andrew P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gardner, Kenneth D.</au><au>Burnside, Janet S.</au><au>Skipper, Betty J.</au><au>Swan, Suzanne K.</au><au>Bennett, William M.</au><au>Connors, Bret A.</au><au>Evan, Andrew P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the probability that kidneys are different in autosomal dominant polycystic disease</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>42</volume><issue>5</issue><spage>1199</spage><epage>1206</epage><pages>1199-1206</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>On the probability that kidneys are different in autosomal dominant polycystic disease. We hypothesized that highly variable cyst fluid sodium concentrations are a characteristic of every kidney in autosomal dominant polycystic kidney disease (ADPKD). We added our data on sodium concentrations in 124 fluids from ten ADPKD kidneys to data published by others of concentrations in 32 fluids from five kidneys. The values ranged from 3 to 207 mEq/liter; none fell between 59 and 74 mEq/liter. Fluids were designated as low (< 60 mEq/liter; 50 fluids) or high (> 60 mEq/liter; 106 fluids) sodium fluids. Transmission electron microscopy identified differences in the depths of apical tight junctions between cells from cyst walls of 12 of the low and 10 of the high sodium fluids from two kidneys (mean ± SE depths of 2039 ± 74 Å vs. 386 ± 18A respectively; P < 0.0001). When fluids were grouped by kidney of origin, six of the 15 kidneys had only high sodium fluids. The probability that chance had led to the sampling of only high sodium fluids in these organs, given that 32% of all fluids were low sodium fluids, was calculated at < 0.00015. The possibility must be considered that all kidneys are not alike in ADPKD.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1453604</pmid><doi>10.1038/ki.1992.405</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Body Fluids - metabolism Creatinine - metabolism Female Humans Intercellular Junctions - metabolism Intercellular Junctions - ultrastructure Kidney - metabolism Kidney - ultrastructure Kidneys Male Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Middle Aged Nephrology. Urinary tract diseases Osmolar Concentration Polycystic Kidney, Autosomal Dominant - metabolism Polycystic Kidney, Autosomal Dominant - pathology Sodium - metabolism Tissue Distribution Tumors of the urinary system |
| title | On the probability that kidneys are different in autosomal dominant polycystic disease |
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