Determination of Fab−Hinge Disulfide Connectivity in Structural Isoforms of a Recombinant Human Immunoglobulin G2 Antibody

The detection and characterization of unexpected disulfide-mediated structural variants of human immunoglobulin G2 (IgG2) antibodies was recently the subject of two copublications. , In this paper, we present data to confirm the previously reported structures and elucidate the complete disulfide con...

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Veröffentlicht in:	Analytical chemistry (Washington) 2010-02, Vol.82 (3), p.1090-1099
Hauptverfasser:	Zhang, Bing, Harder, Adam G, Connelly, Heather M, Maheu, Lorna L, Cockrill, Steven L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical chemistry Antibodies, immunoglobulins Biological and medical sciences Chemical compounds Disulfides - analysis Disulfides - chemistry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin G - chemistry Immunoglobulin G - genetics Immunoglobulins Molecular immunology Molecular Sequence Data Molecular structure Peptide Mapping - methods Peptides Protein Isoforms - chemistry Protein Isoforms - genetics Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics
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