In vivo characterization of human pigmented lesions by degree of linear polarization image maps using incident linearly polarized light
Background and Objective Melanoma is the most serious form of skin cancer and often appears as an evolving multicolored skin growth. It is well documented that pre‐existing atypical or dysplastic nevi can evolve into a melanoma. The development of an in vivo imaging system to characterize benign and...
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| Veröffentlicht in: | Lasers in surgery and medicine 2010-01, Vol.42 (1), p.76-85 |
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| creator | Kim, Jihoon John, Raheel Wu, Paul J. Martini, Mary C. Walsh Jr, Joseph T. |
| description | Background and Objective
Melanoma is the most serious form of skin cancer and often appears as an evolving multicolored skin growth. It is well documented that pre‐existing atypical or dysplastic nevi can evolve into a melanoma. The development of an in vivo imaging system to characterize benign and malignant nevi has been emphasized to aid in early detection of melanoma. The goal of this study is to utilize a novel Stokes polarimetry imaging (SPI) system for the characterization of pigmented lesions, and to evaluate the SPI system in comparison to dermoscopy and histology images.
Study Design/Materials and Methods
Linearly polarized light with varying incident polarization angles (IPA) illuminated various types of pigmented lesions. The melanocytic nesting patterns of pigmented lesions were characterized by constructing the degree‐of‐linear‐polarization (DOLP) image map with comparison to dermoscopy and histology. The incident polarized light was filtered by visible filters for spectral imaging and incident deeply penetrating red light was used to correlate the SPI image with histopathological examination.
Results
The DOLP images with varying IPA at different visible wavelengths were used to characterize various kinds of pigmented lesions by showing subsurface melanocytic nesting distribution as well as morphological information with better resolution and contrast. In correlation with dermoscopy and histology, various defining features such as compound, junctional, lentiginous, reticular, globular patterns of melanocytic nests were identified.
Conclusion
When imaging pigmented melanocytic lesions, the SPI system with varying IPA at the red light wavelength can better define the melanocytic nesting patterns in both the dermal epidermal junction and the dermis. The SPI system has the potential to be an effective in vivo method of detecting pre‐malignant nevi and melanoma. Lasers Surg. Med. 42:76–85, 2010. © 2010 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/lsm.20866 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733529880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1017961173</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3956-fbbf3ebc39574bedd194638c9c001261f21c6074e224a34a94aca5cc8f4be9973</originalsourceid><addsrcrecordid>eNp9kcuO1DAQRS0EYpqGBT-AvAMWmSnbaTteohEzjNSAeIml5TiVtCGvsZOB5gf4bdz0YwercsnnnkVdQp4yOGcA_KKN3TmHQsp7ZMFAy0wzYPfJAlh6F6D5GXkU4zcAEBzUQ3LGAZTKNVuQ3zc9vfN3A3UbG6ybMPhfdvJDT4eabubO9nT0TYf9hBVtMaafSMstrbAJiDuo9T3aQMehtaes72yDtLNjpHP0fUN973yVJAe63R75ndU3m-kxeVDbNuKTw1ySL1evP1--ydbvr28uX60zJ_RKZnVZ1gLL3aLyEquK6VyKwmkHwLhkNWdOgsqR89yK3OrcOrtyrqgTrbUSS_J87x3DcDtjnEzno8O2tT0OczRKiBXXRQGJfPFfMp1YaclYSizJyz3qwhBjwNqMIZ0gbBNkdg2Z1JD521Binx20c9lhdSKPlSTgYg_88C1u_20y609vj8psn_Bxwp-nhA3fjVRCrczXd9fmo9TiQ8GUuRJ_AGeirC0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1017961173</pqid></control><display><type>article</type><title>In vivo characterization of human pigmented lesions by degree of linear polarization image maps using incident linearly polarized light</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kim, Jihoon ; John, Raheel ; Wu, Paul J. ; Martini, Mary C. ; Walsh Jr, Joseph T.</creator><creatorcontrib>Kim, Jihoon ; John, Raheel ; Wu, Paul J. ; Martini, Mary C. ; Walsh Jr, Joseph T.</creatorcontrib><description>Background and Objective
Melanoma is the most serious form of skin cancer and often appears as an evolving multicolored skin growth. It is well documented that pre‐existing atypical or dysplastic nevi can evolve into a melanoma. The development of an in vivo imaging system to characterize benign and malignant nevi has been emphasized to aid in early detection of melanoma. The goal of this study is to utilize a novel Stokes polarimetry imaging (SPI) system for the characterization of pigmented lesions, and to evaluate the SPI system in comparison to dermoscopy and histology images.
Study Design/Materials and Methods
Linearly polarized light with varying incident polarization angles (IPA) illuminated various types of pigmented lesions. The melanocytic nesting patterns of pigmented lesions were characterized by constructing the degree‐of‐linear‐polarization (DOLP) image map with comparison to dermoscopy and histology. The incident polarized light was filtered by visible filters for spectral imaging and incident deeply penetrating red light was used to correlate the SPI image with histopathological examination.
Results
The DOLP images with varying IPA at different visible wavelengths were used to characterize various kinds of pigmented lesions by showing subsurface melanocytic nesting distribution as well as morphological information with better resolution and contrast. In correlation with dermoscopy and histology, various defining features such as compound, junctional, lentiginous, reticular, globular patterns of melanocytic nests were identified.
Conclusion
When imaging pigmented melanocytic lesions, the SPI system with varying IPA at the red light wavelength can better define the melanocytic nesting patterns in both the dermal epidermal junction and the dermis. The SPI system has the potential to be an effective in vivo method of detecting pre‐malignant nevi and melanoma. Lasers Surg. Med. 42:76–85, 2010. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>ISSN: 1096-9101</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.20866</identifier><identifier>PMID: 20077491</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Benign ; Cohort Studies ; degree of linear polarization ; Dermis ; dysplastic nevus ; Equipment Design ; Filters ; Humans ; Image Processing, Computer-Assisted ; imaging ; incident polarization angle ; Lasers ; Light effects ; Melanoma ; Microscopy, Polarization ; Nests ; Nevus, Pigmented - diagnosis ; Optical Devices ; Polarization ; Polarized light ; Predictive Value of Tests ; Reproducibility of Results ; Scanning Laser Polarimetry - instrumentation ; Skin ; Skin cancer ; Skin Neoplasms - diagnosis ; Stokes polarimetry imaging ; Wavelength</subject><ispartof>Lasers in surgery and medicine, 2010-01, Vol.42 (1), p.76-85</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3956-fbbf3ebc39574bedd194638c9c001261f21c6074e224a34a94aca5cc8f4be9973</citedby><cites>FETCH-LOGICAL-c3956-fbbf3ebc39574bedd194638c9c001261f21c6074e224a34a94aca5cc8f4be9973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.20866$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.20866$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20077491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jihoon</creatorcontrib><creatorcontrib>John, Raheel</creatorcontrib><creatorcontrib>Wu, Paul J.</creatorcontrib><creatorcontrib>Martini, Mary C.</creatorcontrib><creatorcontrib>Walsh Jr, Joseph T.</creatorcontrib><title>In vivo characterization of human pigmented lesions by degree of linear polarization image maps using incident linearly polarized light</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objective
Melanoma is the most serious form of skin cancer and often appears as an evolving multicolored skin growth. It is well documented that pre‐existing atypical or dysplastic nevi can evolve into a melanoma. The development of an in vivo imaging system to characterize benign and malignant nevi has been emphasized to aid in early detection of melanoma. The goal of this study is to utilize a novel Stokes polarimetry imaging (SPI) system for the characterization of pigmented lesions, and to evaluate the SPI system in comparison to dermoscopy and histology images.
Study Design/Materials and Methods
Linearly polarized light with varying incident polarization angles (IPA) illuminated various types of pigmented lesions. The melanocytic nesting patterns of pigmented lesions were characterized by constructing the degree‐of‐linear‐polarization (DOLP) image map with comparison to dermoscopy and histology. The incident polarized light was filtered by visible filters for spectral imaging and incident deeply penetrating red light was used to correlate the SPI image with histopathological examination.
Results
The DOLP images with varying IPA at different visible wavelengths were used to characterize various kinds of pigmented lesions by showing subsurface melanocytic nesting distribution as well as morphological information with better resolution and contrast. In correlation with dermoscopy and histology, various defining features such as compound, junctional, lentiginous, reticular, globular patterns of melanocytic nests were identified.
Conclusion
When imaging pigmented melanocytic lesions, the SPI system with varying IPA at the red light wavelength can better define the melanocytic nesting patterns in both the dermal epidermal junction and the dermis. The SPI system has the potential to be an effective in vivo method of detecting pre‐malignant nevi and melanoma. Lasers Surg. Med. 42:76–85, 2010. © 2010 Wiley‐Liss, Inc.</description><subject>Benign</subject><subject>Cohort Studies</subject><subject>degree of linear polarization</subject><subject>Dermis</subject><subject>dysplastic nevus</subject><subject>Equipment Design</subject><subject>Filters</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>imaging</subject><subject>incident polarization angle</subject><subject>Lasers</subject><subject>Light effects</subject><subject>Melanoma</subject><subject>Microscopy, Polarization</subject><subject>Nests</subject><subject>Nevus, Pigmented - diagnosis</subject><subject>Optical Devices</subject><subject>Polarization</subject><subject>Polarized light</subject><subject>Predictive Value of Tests</subject><subject>Reproducibility of Results</subject><subject>Scanning Laser Polarimetry - instrumentation</subject><subject>Skin</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Stokes polarimetry imaging</subject><subject>Wavelength</subject><issn>0196-8092</issn><issn>1096-9101</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO1DAQRS0EYpqGBT-AvAMWmSnbaTteohEzjNSAeIml5TiVtCGvsZOB5gf4bdz0YwercsnnnkVdQp4yOGcA_KKN3TmHQsp7ZMFAy0wzYPfJAlh6F6D5GXkU4zcAEBzUQ3LGAZTKNVuQ3zc9vfN3A3UbG6ybMPhfdvJDT4eabubO9nT0TYf9hBVtMaafSMstrbAJiDuo9T3aQMehtaes72yDtLNjpHP0fUN973yVJAe63R75ndU3m-kxeVDbNuKTw1ySL1evP1--ydbvr28uX60zJ_RKZnVZ1gLL3aLyEquK6VyKwmkHwLhkNWdOgsqR89yK3OrcOrtyrqgTrbUSS_J87x3DcDtjnEzno8O2tT0OczRKiBXXRQGJfPFfMp1YaclYSizJyz3qwhBjwNqMIZ0gbBNkdg2Z1JD521Binx20c9lhdSKPlSTgYg_88C1u_20y609vj8psn_Bxwp-nhA3fjVRCrczXd9fmo9TiQ8GUuRJ_AGeirC0</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Kim, Jihoon</creator><creator>John, Raheel</creator><creator>Wu, Paul J.</creator><creator>Martini, Mary C.</creator><creator>Walsh Jr, Joseph T.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201001</creationdate><title>In vivo characterization of human pigmented lesions by degree of linear polarization image maps using incident linearly polarized light</title><author>Kim, Jihoon ; John, Raheel ; Wu, Paul J. ; Martini, Mary C. ; Walsh Jr, Joseph T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3956-fbbf3ebc39574bedd194638c9c001261f21c6074e224a34a94aca5cc8f4be9973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Benign</topic><topic>Cohort Studies</topic><topic>degree of linear polarization</topic><topic>Dermis</topic><topic>dysplastic nevus</topic><topic>Equipment Design</topic><topic>Filters</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>imaging</topic><topic>incident polarization angle</topic><topic>Lasers</topic><topic>Light effects</topic><topic>Melanoma</topic><topic>Microscopy, Polarization</topic><topic>Nests</topic><topic>Nevus, Pigmented - diagnosis</topic><topic>Optical Devices</topic><topic>Polarization</topic><topic>Polarized light</topic><topic>Predictive Value of Tests</topic><topic>Reproducibility of Results</topic><topic>Scanning Laser Polarimetry - instrumentation</topic><topic>Skin</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Stokes polarimetry imaging</topic><topic>Wavelength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jihoon</creatorcontrib><creatorcontrib>John, Raheel</creatorcontrib><creatorcontrib>Wu, Paul J.</creatorcontrib><creatorcontrib>Martini, Mary C.</creatorcontrib><creatorcontrib>Walsh Jr, Joseph T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jihoon</au><au>John, Raheel</au><au>Wu, Paul J.</au><au>Martini, Mary C.</au><au>Walsh Jr, Joseph T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo characterization of human pigmented lesions by degree of linear polarization image maps using incident linearly polarized light</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>2010-01</date><risdate>2010</risdate><volume>42</volume><issue>1</issue><spage>76</spage><epage>85</epage><pages>76-85</pages><issn>0196-8092</issn><issn>1096-9101</issn><eissn>1096-9101</eissn><abstract>Background and Objective
Melanoma is the most serious form of skin cancer and often appears as an evolving multicolored skin growth. It is well documented that pre‐existing atypical or dysplastic nevi can evolve into a melanoma. The development of an in vivo imaging system to characterize benign and malignant nevi has been emphasized to aid in early detection of melanoma. The goal of this study is to utilize a novel Stokes polarimetry imaging (SPI) system for the characterization of pigmented lesions, and to evaluate the SPI system in comparison to dermoscopy and histology images.
Study Design/Materials and Methods
Linearly polarized light with varying incident polarization angles (IPA) illuminated various types of pigmented lesions. The melanocytic nesting patterns of pigmented lesions were characterized by constructing the degree‐of‐linear‐polarization (DOLP) image map with comparison to dermoscopy and histology. The incident polarized light was filtered by visible filters for spectral imaging and incident deeply penetrating red light was used to correlate the SPI image with histopathological examination.
Results
The DOLP images with varying IPA at different visible wavelengths were used to characterize various kinds of pigmented lesions by showing subsurface melanocytic nesting distribution as well as morphological information with better resolution and contrast. In correlation with dermoscopy and histology, various defining features such as compound, junctional, lentiginous, reticular, globular patterns of melanocytic nests were identified.
Conclusion
When imaging pigmented melanocytic lesions, the SPI system with varying IPA at the red light wavelength can better define the melanocytic nesting patterns in both the dermal epidermal junction and the dermis. The SPI system has the potential to be an effective in vivo method of detecting pre‐malignant nevi and melanoma. Lasers Surg. Med. 42:76–85, 2010. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20077491</pmid><doi>10.1002/lsm.20866</doi><tpages>10</tpages></addata></record> |
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| ispartof | Lasers in surgery and medicine, 2010-01, Vol.42 (1), p.76-85 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Benign Cohort Studies degree of linear polarization Dermis dysplastic nevus Equipment Design Filters Humans Image Processing, Computer-Assisted imaging incident polarization angle Lasers Light effects Melanoma Microscopy, Polarization Nests Nevus, Pigmented - diagnosis Optical Devices Polarization Polarized light Predictive Value of Tests Reproducibility of Results Scanning Laser Polarimetry - instrumentation Skin Skin cancer Skin Neoplasms - diagnosis Stokes polarimetry imaging Wavelength |
| title | In vivo characterization of human pigmented lesions by degree of linear polarization image maps using incident linearly polarized light |
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