Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose
Using mixture experimental design, the effect of carbomer (Carbopol® 971P NF) and hydroxypropylmethylcellulose (Methocel® K100M or Methocel® K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was a...
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| Veröffentlicht in: | Archives of pharmacal research 2009-12, Vol.32 (12), p.1767-1774 |
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| container_title | Archives of pharmacal research |
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| creator | Petrovic, Aleksandra Cvetkovic, Nebojsa Ibric, Svetlana Trajkovic, Svetlana Djuric, Zorica Popadic, Dragica Popovic, Radmila |
| description | Using mixture experimental design, the effect of carbomer (Carbopol® 971P NF) and hydroxypropylmethylcellulose (Methocel® K100M or Methocel® K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case — II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile. |
| doi_str_mv | 10.1007/s12272-009-2215-9 |
| format | Article |
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The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case — II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.</description><identifier>ISSN: 0253-6269</identifier><identifier>EISSN: 1976-3786</identifier><identifier>DOI: 10.1007/s12272-009-2215-9</identifier><identifier>PMID: 20162406</identifier><language>eng</language><publisher>Heidelberg: Pharmaceutical Society of Korea</publisher><subject>Acrylates - chemistry ; Chemistry, Pharmaceutical - methods ; Delayed-Action Preparations ; Drug Actions ; Drug Design ; Excipients - chemistry ; Hypromellose Derivatives ; Kinetics ; Medicine ; Methylcellulose - analogs & derivatives ; Methylcellulose - chemistry ; Pharmacology/Toxicology ; Pharmacy ; Solubility ; Spectrophotometry, Ultraviolet ; Tablets - chemistry ; Theophylline - chemistry ; Theophylline - isolation & purification</subject><ispartof>Archives of pharmacal research, 2009-12, Vol.32 (12), p.1767-1774</ispartof><rights>The Pharmaceutical Society of Korea and Springer Netherlands 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2589-f34159695c405a46cb6407d98fc3ca4beb015a6a90abda8ccf64dc1a2ef513f33</citedby><cites>FETCH-LOGICAL-c2589-f34159695c405a46cb6407d98fc3ca4beb015a6a90abda8ccf64dc1a2ef513f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12272-009-2215-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12272-009-2215-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27902,27903,41466,42535,51296</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20162406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrovic, Aleksandra</creatorcontrib><creatorcontrib>Cvetkovic, Nebojsa</creatorcontrib><creatorcontrib>Ibric, Svetlana</creatorcontrib><creatorcontrib>Trajkovic, Svetlana</creatorcontrib><creatorcontrib>Djuric, Zorica</creatorcontrib><creatorcontrib>Popadic, Dragica</creatorcontrib><creatorcontrib>Popovic, Radmila</creatorcontrib><title>Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose</title><title>Archives of pharmacal research</title><addtitle>Arch. Pharm. Res</addtitle><addtitle>Arch Pharm Res</addtitle><description>Using mixture experimental design, the effect of carbomer (Carbopol® 971P NF) and hydroxypropylmethylcellulose (Methocel® K100M or Methocel® K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case — II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.</description><subject>Acrylates - chemistry</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Delayed-Action Preparations</subject><subject>Drug Actions</subject><subject>Drug Design</subject><subject>Excipients - chemistry</subject><subject>Hypromellose Derivatives</subject><subject>Kinetics</subject><subject>Medicine</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Methylcellulose - chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Solubility</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tablets - chemistry</subject><subject>Theophylline - chemistry</subject><subject>Theophylline - isolation & purification</subject><issn>0253-6269</issn><issn>1976-3786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1ERYe2D8AGeccq4J_YGS-rigJSJTawthznZsaVYwfbkSY8CM-LpymwY3UX95xP956D0BtK3lNCug-ZMtaxhhDVMEZFo16gHVWdbHi3ly_RjjDBG8mkukSvc34khEshxCt0yQiVrCVyh37dzrN31hQXA44jntypLAkwnGZIboJQjMcDZHcI2AVcjoDHmKbFbw4TBhzn4ib38x_ClOROuJjeQ8nYxspwwYUDtib1cYL0ZDuuQ4qntZlTnFc_QTmu3oL3i48ZrtHFaHyGm-d5hb7ff_x297l5-Prpy93tQ2OZ2Ktm5C0VSiphWyJMK20vW9INaj9abk3bQ0-oMNIoYvrB7K0dZTtYahiMgvKR8yv0buPWK34skIueXD5fYQLEJeuOc8FUjbMq6aa0KeacYNRzzcekVVOiz23orQ1d29DnNrSqnrfP9KWfYPjr-BN_FbBNkOsqHCDpx7ikUD_-D_U3fQeatg</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Petrovic, Aleksandra</creator><creator>Cvetkovic, Nebojsa</creator><creator>Ibric, Svetlana</creator><creator>Trajkovic, Svetlana</creator><creator>Djuric, Zorica</creator><creator>Popadic, Dragica</creator><creator>Popovic, Radmila</creator><general>Pharmaceutical Society of Korea</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose</title><author>Petrovic, Aleksandra ; Cvetkovic, Nebojsa ; Ibric, Svetlana ; Trajkovic, Svetlana ; Djuric, Zorica ; Popadic, Dragica ; Popovic, Radmila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2589-f34159695c405a46cb6407d98fc3ca4beb015a6a90abda8ccf64dc1a2ef513f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acrylates - chemistry</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Delayed-Action Preparations</topic><topic>Drug Actions</topic><topic>Drug Design</topic><topic>Excipients - chemistry</topic><topic>Hypromellose Derivatives</topic><topic>Kinetics</topic><topic>Medicine</topic><topic>Methylcellulose - analogs & derivatives</topic><topic>Methylcellulose - chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Solubility</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tablets - chemistry</topic><topic>Theophylline - chemistry</topic><topic>Theophylline - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrovic, Aleksandra</creatorcontrib><creatorcontrib>Cvetkovic, Nebojsa</creatorcontrib><creatorcontrib>Ibric, Svetlana</creatorcontrib><creatorcontrib>Trajkovic, Svetlana</creatorcontrib><creatorcontrib>Djuric, Zorica</creatorcontrib><creatorcontrib>Popadic, Dragica</creatorcontrib><creatorcontrib>Popovic, Radmila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrovic, Aleksandra</au><au>Cvetkovic, Nebojsa</au><au>Ibric, Svetlana</au><au>Trajkovic, Svetlana</au><au>Djuric, Zorica</au><au>Popadic, Dragica</au><au>Popovic, Radmila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose</atitle><jtitle>Archives of pharmacal research</jtitle><stitle>Arch. Pharm. Res</stitle><addtitle>Arch Pharm Res</addtitle><date>2009-12</date><risdate>2009</risdate><volume>32</volume><issue>12</issue><spage>1767</spage><epage>1774</epage><pages>1767-1774</pages><issn>0253-6269</issn><eissn>1976-3786</eissn><abstract>Using mixture experimental design, the effect of carbomer (Carbopol® 971P NF) and hydroxypropylmethylcellulose (Methocel® K100M or Methocel® K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case — II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.</abstract><cop>Heidelberg</cop><pub>Pharmaceutical Society of Korea</pub><pmid>20162406</pmid><doi>10.1007/s12272-009-2215-9</doi><tpages>8</tpages></addata></record> |
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| issn | 0253-6269 1976-3786 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Acrylates - chemistry Chemistry, Pharmaceutical - methods Delayed-Action Preparations Drug Actions Drug Design Excipients - chemistry Hypromellose Derivatives Kinetics Medicine Methylcellulose - analogs & derivatives Methylcellulose - chemistry Pharmacology/Toxicology Pharmacy Solubility Spectrophotometry, Ultraviolet Tablets - chemistry Theophylline - chemistry Theophylline - isolation & purification |
| title | Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose |
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