KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer
Objectives/Hypothesis: To investigate the expression of KAI1 COOH‐terminal interacting tetraspanin (KITENIN) in patients with laryngeal cancers and to examine the correlation between its expression and various clinical and pathological variables. Study Design: Cross‐sectional study with planned data...
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| Veröffentlicht in: | The Laryngoscope 2010-05, Vol.120 (5), p.953-958 |
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| container_title | The Laryngoscope |
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| creator | Lee, Joon Kyoo Yoon, Tae Mi Seo, Deok Jung Sun, Eun Gene Bae, Jeong A. Lim, Sang Chul Choi, Yoo Duk Lee, Jae Hyuk Joo, Young Eun Kim, Kyung Keun |
| description | Objectives/Hypothesis:
To investigate the expression of KAI1 COOH‐terminal interacting tetraspanin (KITENIN) in patients with laryngeal cancers and to examine the correlation between its expression and various clinical and pathological variables.
Study Design:
Cross‐sectional study with planned data collection.
Methods:
Tumor specimens were collected from 32 patients with laryngeal squamous carcinoma (collection of consecutive 32 tumor samples; 14 early stage, 18 advanced stage). Expression of KITENIN in the tissues obtained was determined by Western blot analysis and immunohistochemical staining. The patient characteristics including age, gender, tumor location, histology, stage, tumor extent, lymph node metastasis, and survival were obtained by review of the hospital records.
Results:
KITENIN expression was significantly increased in laryngeal cancer tissues compared to adjacent normal tissue mucosa, as well as in metastatic lymph nodes compared to nonmetastatic lymph nodes. High KITENIN expression was significantly associated with advanced stage, tumor extent, and lymph node metastasis (P = .016, .016, and .005, respectively). There was no difference in the overall survival and disease‐free survival between the low‐ and high‐KITENIN expression groups among patients with laryngeal cancer.
Conclusions:
These results suggest that KITENIN expression may be associated with tumor progression in patients with laryngeal cancer. Further studies are needed to determine whether KITENIN expression adds prognostic value to conventional factors, such as the stage and status of metastasis, in a large series with a long period of follow‐up. Laryngoscope, 2010 |
| doi_str_mv | 10.1002/lary.20864 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733525428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733525428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3114-f117908ff0bad162908ec6304112eb1e7579b648173be9e3a682111966474f663</originalsourceid><addsrcrecordid>eNp9kE9PGzEQxS1EVVLaSz9A5QvqH2nBY3vt3WMU0RBIEwmBgJPl3Z1FbjdOam9a8u3rNIHeevLI85s38x4h74GdAmP8rLNhc8pZoeQBGUAuIJNlmR-SQWqKrMj5_RF5E-N3xkCLnL0mR5xJzlVRDkh7NZwAHc3nF1mPYeG87ajzqbR17_wj7bEPNq6sd55-uprcnM8ms88Un1YBY3RLn2CKNnQban1DbfPL-hobuj3JP2ISq7cf4S151dou4rv9e0xuv57fjC6y6Xw8GQ2nWS0AZNYC6JIVbcsq24DiqcZaCSYBOFaAOtdlpWSRfFRYorCq4ABQKiW1bJUSx-TjTncVlj_XGHuzcLHGrrMel-totBA5zyUvEvllR9ZhGWPA1qyCW6SzDTCzjdVsPZi_sSb4w152XS2weUGfc0zAyR6wsbZdG5JrF_9xXJcF0yxxsON-uw43_1lppsPrh-fl2W7GxR6fXmZs-GGUFjo3d7OxGY0v78cwuzTfxB-T1pzZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733525428</pqid></control><display><type>article</type><title>KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Lee, Joon Kyoo ; Yoon, Tae Mi ; Seo, Deok Jung ; Sun, Eun Gene ; Bae, Jeong A. ; Lim, Sang Chul ; Choi, Yoo Duk ; Lee, Jae Hyuk ; Joo, Young Eun ; Kim, Kyung Keun</creator><creatorcontrib>Lee, Joon Kyoo ; Yoon, Tae Mi ; Seo, Deok Jung ; Sun, Eun Gene ; Bae, Jeong A. ; Lim, Sang Chul ; Choi, Yoo Duk ; Lee, Jae Hyuk ; Joo, Young Eun ; Kim, Kyung Keun</creatorcontrib><description>Objectives/Hypothesis:
To investigate the expression of KAI1 COOH‐terminal interacting tetraspanin (KITENIN) in patients with laryngeal cancers and to examine the correlation between its expression and various clinical and pathological variables.
Study Design:
Cross‐sectional study with planned data collection.
Methods:
Tumor specimens were collected from 32 patients with laryngeal squamous carcinoma (collection of consecutive 32 tumor samples; 14 early stage, 18 advanced stage). Expression of KITENIN in the tissues obtained was determined by Western blot analysis and immunohistochemical staining. The patient characteristics including age, gender, tumor location, histology, stage, tumor extent, lymph node metastasis, and survival were obtained by review of the hospital records.
Results:
KITENIN expression was significantly increased in laryngeal cancer tissues compared to adjacent normal tissue mucosa, as well as in metastatic lymph nodes compared to nonmetastatic lymph nodes. High KITENIN expression was significantly associated with advanced stage, tumor extent, and lymph node metastasis (P = .016, .016, and .005, respectively). There was no difference in the overall survival and disease‐free survival between the low‐ and high‐KITENIN expression groups among patients with laryngeal cancer.
Conclusions:
These results suggest that KITENIN expression may be associated with tumor progression in patients with laryngeal cancer. Further studies are needed to determine whether KITENIN expression adds prognostic value to conventional factors, such as the stage and status of metastasis, in a large series with a long period of follow‐up. Laryngoscope, 2010</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.20864</identifier><identifier>PMID: 20422689</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biopsy ; Blotting, Western ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Carrier Proteins - analysis ; Disease-Free Survival ; Female ; Humans ; Immunoenzyme Techniques ; KAI1 COOH-terminal interacting tetraspanin (KITENIN) ; laryngeal neoplasms ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - surgery ; Larynx - pathology ; Level of Evidence: 1a ; Lymphatic Metastasis - pathology ; Male ; Medical sciences ; Membrane Proteins - analysis ; Middle Aged ; Neoplasm Staging ; Otorhinolaryngology. Stomatology ; Prognosis ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>The Laryngoscope, 2010-05, Vol.120 (5), p.953-958</ispartof><rights>Copyright © 2010 The American Laryngological, Rhinological, and Otological Society, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3114-f117908ff0bad162908ec6304112eb1e7579b648173be9e3a682111966474f663</citedby><cites>FETCH-LOGICAL-c3114-f117908ff0bad162908ec6304112eb1e7579b648173be9e3a682111966474f663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.20864$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.20864$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22798070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20422689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Joon Kyoo</creatorcontrib><creatorcontrib>Yoon, Tae Mi</creatorcontrib><creatorcontrib>Seo, Deok Jung</creatorcontrib><creatorcontrib>Sun, Eun Gene</creatorcontrib><creatorcontrib>Bae, Jeong A.</creatorcontrib><creatorcontrib>Lim, Sang Chul</creatorcontrib><creatorcontrib>Choi, Yoo Duk</creatorcontrib><creatorcontrib>Lee, Jae Hyuk</creatorcontrib><creatorcontrib>Joo, Young Eun</creatorcontrib><creatorcontrib>Kim, Kyung Keun</creatorcontrib><title>KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis:
To investigate the expression of KAI1 COOH‐terminal interacting tetraspanin (KITENIN) in patients with laryngeal cancers and to examine the correlation between its expression and various clinical and pathological variables.
Study Design:
Cross‐sectional study with planned data collection.
Methods:
Tumor specimens were collected from 32 patients with laryngeal squamous carcinoma (collection of consecutive 32 tumor samples; 14 early stage, 18 advanced stage). Expression of KITENIN in the tissues obtained was determined by Western blot analysis and immunohistochemical staining. The patient characteristics including age, gender, tumor location, histology, stage, tumor extent, lymph node metastasis, and survival were obtained by review of the hospital records.
Results:
KITENIN expression was significantly increased in laryngeal cancer tissues compared to adjacent normal tissue mucosa, as well as in metastatic lymph nodes compared to nonmetastatic lymph nodes. High KITENIN expression was significantly associated with advanced stage, tumor extent, and lymph node metastasis (P = .016, .016, and .005, respectively). There was no difference in the overall survival and disease‐free survival between the low‐ and high‐KITENIN expression groups among patients with laryngeal cancer.
Conclusions:
These results suggest that KITENIN expression may be associated with tumor progression in patients with laryngeal cancer. Further studies are needed to determine whether KITENIN expression adds prognostic value to conventional factors, such as the stage and status of metastasis, in a large series with a long period of follow‐up. Laryngoscope, 2010</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy</subject><subject>Blotting, Western</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Carrier Proteins - analysis</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>KAI1 COOH-terminal interacting tetraspanin (KITENIN)</subject><subject>laryngeal neoplasms</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Larynx - pathology</subject><subject>Level of Evidence: 1a</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - analysis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PGzEQxS1EVVLaSz9A5QvqH2nBY3vt3WMU0RBIEwmBgJPl3Z1FbjdOam9a8u3rNIHeevLI85s38x4h74GdAmP8rLNhc8pZoeQBGUAuIJNlmR-SQWqKrMj5_RF5E-N3xkCLnL0mR5xJzlVRDkh7NZwAHc3nF1mPYeG87ajzqbR17_wj7bEPNq6sd55-uprcnM8ms88Un1YBY3RLn2CKNnQban1DbfPL-hobuj3JP2ISq7cf4S151dou4rv9e0xuv57fjC6y6Xw8GQ2nWS0AZNYC6JIVbcsq24DiqcZaCSYBOFaAOtdlpWSRfFRYorCq4ABQKiW1bJUSx-TjTncVlj_XGHuzcLHGrrMel-totBA5zyUvEvllR9ZhGWPA1qyCW6SzDTCzjdVsPZi_sSb4w152XS2weUGfc0zAyR6wsbZdG5JrF_9xXJcF0yxxsON-uw43_1lppsPrh-fl2W7GxR6fXmZs-GGUFjo3d7OxGY0v78cwuzTfxB-T1pzZ</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Lee, Joon Kyoo</creator><creator>Yoon, Tae Mi</creator><creator>Seo, Deok Jung</creator><creator>Sun, Eun Gene</creator><creator>Bae, Jeong A.</creator><creator>Lim, Sang Chul</creator><creator>Choi, Yoo Duk</creator><creator>Lee, Jae Hyuk</creator><creator>Joo, Young Eun</creator><creator>Kim, Kyung Keun</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer</title><author>Lee, Joon Kyoo ; Yoon, Tae Mi ; Seo, Deok Jung ; Sun, Eun Gene ; Bae, Jeong A. ; Lim, Sang Chul ; Choi, Yoo Duk ; Lee, Jae Hyuk ; Joo, Young Eun ; Kim, Kyung Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3114-f117908ff0bad162908ec6304112eb1e7579b648173be9e3a682111966474f663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy</topic><topic>Blotting, Western</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Carrier Proteins - analysis</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>KAI1 COOH-terminal interacting tetraspanin (KITENIN)</topic><topic>laryngeal neoplasms</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>Larynx - pathology</topic><topic>Level of Evidence: 1a</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - analysis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Joon Kyoo</creatorcontrib><creatorcontrib>Yoon, Tae Mi</creatorcontrib><creatorcontrib>Seo, Deok Jung</creatorcontrib><creatorcontrib>Sun, Eun Gene</creatorcontrib><creatorcontrib>Bae, Jeong A.</creatorcontrib><creatorcontrib>Lim, Sang Chul</creatorcontrib><creatorcontrib>Choi, Yoo Duk</creatorcontrib><creatorcontrib>Lee, Jae Hyuk</creatorcontrib><creatorcontrib>Joo, Young Eun</creatorcontrib><creatorcontrib>Kim, Kyung Keun</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Joon Kyoo</au><au>Yoon, Tae Mi</au><au>Seo, Deok Jung</au><au>Sun, Eun Gene</au><au>Bae, Jeong A.</au><au>Lim, Sang Chul</au><au>Choi, Yoo Duk</au><au>Lee, Jae Hyuk</au><au>Joo, Young Eun</au><au>Kim, Kyung Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2010-05</date><risdate>2010</risdate><volume>120</volume><issue>5</issue><spage>953</spage><epage>958</epage><pages>953-958</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives/Hypothesis:
To investigate the expression of KAI1 COOH‐terminal interacting tetraspanin (KITENIN) in patients with laryngeal cancers and to examine the correlation between its expression and various clinical and pathological variables.
Study Design:
Cross‐sectional study with planned data collection.
Methods:
Tumor specimens were collected from 32 patients with laryngeal squamous carcinoma (collection of consecutive 32 tumor samples; 14 early stage, 18 advanced stage). Expression of KITENIN in the tissues obtained was determined by Western blot analysis and immunohistochemical staining. The patient characteristics including age, gender, tumor location, histology, stage, tumor extent, lymph node metastasis, and survival were obtained by review of the hospital records.
Results:
KITENIN expression was significantly increased in laryngeal cancer tissues compared to adjacent normal tissue mucosa, as well as in metastatic lymph nodes compared to nonmetastatic lymph nodes. High KITENIN expression was significantly associated with advanced stage, tumor extent, and lymph node metastasis (P = .016, .016, and .005, respectively). There was no difference in the overall survival and disease‐free survival between the low‐ and high‐KITENIN expression groups among patients with laryngeal cancer.
Conclusions:
These results suggest that KITENIN expression may be associated with tumor progression in patients with laryngeal cancer. Further studies are needed to determine whether KITENIN expression adds prognostic value to conventional factors, such as the stage and status of metastasis, in a large series with a long period of follow‐up. Laryngoscope, 2010</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20422689</pmid><doi>10.1002/lary.20864</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Laryngoscope, 2010-05, Vol.120 (5), p.953-958 |
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| language | eng |
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| subjects | Aged Biological and medical sciences Biomarkers, Tumor - analysis Biopsy Blotting, Western Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Carrier Proteins - analysis Disease-Free Survival Female Humans Immunoenzyme Techniques KAI1 COOH-terminal interacting tetraspanin (KITENIN) laryngeal neoplasms Laryngeal Neoplasms - mortality Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery Larynx - pathology Level of Evidence: 1a Lymphatic Metastasis - pathology Male Medical sciences Membrane Proteins - analysis Middle Aged Neoplasm Staging Otorhinolaryngology. Stomatology Prognosis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | KAI1 COOH-terminal interacting tetraspanin (KITENIN) expression in early and advanced laryngeal cancer |
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