Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats

To investigate the role of tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase, in endothelial function in a model of genetic hypertension, acetylcholine- and sodium nitroprusside (SNP)-induced vasodilator responses were examined in the absence and presence of BH4 in age-matche...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2010-04, Vol.631 (1), p.28-35
Hauptverfasser:	Noguchi, Katsuhiko, Hamadate, Naobumi, Matsuzaki, Toshihiro, Sakanashi, Mayuko, Nakasone, Junko, Sakanashi, Makiko, Tsutsui, Masato, Sakanashi, Matao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Aorta, Abdominal - drug effects Aorta, Abdominal - physiopathology Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Biopterins - administration & dosage Biopterins - analogs & derivatives Biopterins - blood Biopterins - metabolism Biopterins - physiology Blood and lymphatic vessels Cardiology. Vascular system Dietary Supplements Endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Hemodynamics - drug effects Hypertension - genetics Hypertension - physiopathology In Vitro Techniques Infusions, Intravenous Male Medical sciences Neurology Nitrates - blood Nitric oxide Nitric Oxide Synthase - antagonists & inhibitors Nitrites - blood Pharmacology. Drug treatments Rats Rats, Inbred SHR Rats, Inbred WKY Sodium nitroprusside Stroke-prone spontaneously hypertensive rat Tetrahydrobiopterin Time Factors Vascular diseases and vascular malformations of the nervous system Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!